Cover Image

Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos

Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization, blastocoel formation, and correct specification of th...

Full description

Saved in:
Bibliographic Details
Main Authors: Schütz, Aline (Author) , Richter, Christin (Author) , Weissgerber, Petra (Author) , Tsvilovskyy, Volodymyr (Author) , Hesse, Michael (Author) , Ottenheijm, Roger (Author) , Zimmermann, Frank (Author) , Buchholz, Stefanie (Author) , Medert, Rebekka (Author) , Dlugosz, Sascha (Author) , Kuryshev, Vladimir (Author) , Benes, Vladimir (Author) , Flockerzi, Veit (Author) , Fleischmann, Bernd K. (Author) , Cavalié, Adolfo (Author) , Freichel, Marc (Author)
Format: Article (Journal)
Language:English
Published: October 19, 2021
In: Cell reports
Year: 2021, Volume: 37, Issue: 3, Pages: 1-13, e1-e6
ISSN:2211-1247
DOI:10.1016/j.celrep.2021.109851
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.celrep.2021.109851
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2211124721013188
Get full text
Author Notes:Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, and Marc Freichel

MARC

LEADER 00000caa a2200000 c 4500
001 1783564601
003 DE-627
005 20230426063038.0
007 cr uuu---uuuuu
008 211224s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.celrep.2021.109851  |2 doi 
035 |a (DE-627)1783564601 
035 |a (DE-599)KXP1783564601 
035 |a (OCoLC)1341436668 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Schütz, Aline  |e VerfasserIn  |0 (DE-588)1248370023  |0 (DE-627)1783564555  |4 aut 
245 1 0 |a Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos  |c Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, and Marc Freichel 
264 1 |c October 19, 2021 
300 |a 19 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 24.12.2021 
520 |a Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polarization, blastocoel formation, and correct specification of the lineages of the trophectoderm and inner cell mass unaltered despite that free cytoplasmic Ca2+ and Mg2+ is reduced at the two-cell stage. Although Trpm7−/− embryos are able to hatch from the zona pellucida, no expansion of Trpm7−/− trophoblast cells can be observed, and Trpm7−/− embryos are not identifiable in utero at E6.5 or later. Given the proliferation and adhesion defect of Trpm7−/− trophoblast stem cells and the ability of Trpm7−/− ESCs to develop to embryos in tetraploid embryo complementation assays, we postulate a critical role of TRPM7 in trophectoderm cells and their failure during implantation as the most likely explanation of the developmental arrest of Trpm7-deficient mouse embryos. 
650 4 |a calcium 
650 4 |a developmental failure 
650 4 |a embryo implantation 
650 4 |a embryonic lethality 
650 4 |a embryonic stem cells 
650 4 |a magnesium 
650 4 |a trophectoderm 
650 4 |a TRPM7 
700 1 |a Richter, Christin  |e VerfasserIn  |0 (DE-588)1209243423  |0 (DE-627)1696858941  |4 aut 
700 1 |a Weissgerber, Petra  |e VerfasserIn  |4 aut 
700 1 |a Tsvilovskyy, Volodymyr  |e VerfasserIn  |0 (DE-588)1156876850  |0 (DE-627)101983725X  |0 (DE-576)502480181  |4 aut 
700 1 |a Hesse, Michael  |e VerfasserIn  |4 aut 
700 1 |a Ottenheijm, Roger  |d 1995-  |e VerfasserIn  |0 (DE-588)1221305247  |0 (DE-627)1738570312  |4 aut 
700 1 |a Zimmermann, Frank  |e VerfasserIn  |0 (DE-588)1034438654  |0 (DE-627)745596975  |0 (DE-576)382055268  |4 aut 
700 1 |a Buchholz, Stefanie  |e VerfasserIn  |4 aut 
700 1 |a Medert, Rebekka  |e VerfasserIn  |0 (DE-588)1185586539  |0 (DE-627)1664986626  |4 aut 
700 1 |a Dlugosz, Sascha  |e VerfasserIn  |0 (DE-588)1219223301  |0 (DE-627)1735161551  |4 aut 
700 1 |a Kuryshev, Vladimir  |e VerfasserIn  |0 (DE-588)1182049923  |0 (DE-627)1662545037  |4 aut 
700 1 |a Benes, Vladimir  |e VerfasserIn  |0 (DE-588)1155743911  |0 (DE-627)1017952639  |0 (DE-576)501828893  |4 aut 
700 1 |a Flockerzi, Veit  |e VerfasserIn  |4 aut 
700 1 |a Fleischmann, Bernd K.  |e VerfasserIn  |4 aut 
700 1 |a Cavalié, Adolfo  |e VerfasserIn  |4 aut 
700 1 |a Freichel, Marc  |d 1968-  |e VerfasserIn  |0 (DE-588)17286819X  |0 (DE-627)697797147  |0 (DE-576)133723615  |4 aut 
773 0 8 |i Enthalten in  |t Cell reports  |d Maryland Heights, MO : Cell Press, 2012  |g 37(2021), 3, Artikel-ID 109851, Seite 1-13, e1-e6  |h Online-Ressource  |w (DE-627)684964562  |w (DE-600)2649101-1  |w (DE-576)358411572  |x 2211-1247  |7 nnas  |a Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos 
773 1 8 |g volume:37  |g year:2021  |g number:3  |g elocationid:109851  |g pages:1-13, e1-e6  |g extent:19  |a Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos 
856 4 0 |u https://doi.org/10.1016/j.celrep.2021.109851  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S2211124721013188  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20211224 
993 |a Article 
994 |a 2021 
998 |g 17286819X  |a Freichel, Marc  |m 17286819X:Freichel, Marc  |d 50000  |d 54600  |e 50000PF17286819X  |e 54600PF17286819X  |k 0/50000/  |k 1/50000/54600/  |p 16  |y j 
998 |g 1155743911  |a Benes, Vladimir  |m 1155743911:Benes, Vladimir  |p 12 
998 |g 1182049923  |a Kuryshev, Vladimir  |m 1182049923:Kuryshev, Vladimir  |p 11 
998 |g 1219223301  |a Dlugosz, Sascha  |m 1219223301:Dlugosz, Sascha  |d 700000  |d 710000  |e 700000PD1219223301  |e 710000PD1219223301  |k 0/700000/  |k 1/700000/710000/  |p 10 
998 |g 1185586539  |a Medert, Rebekka  |m 1185586539:Medert, Rebekka  |d 50000  |d 54600  |e 50000PM1185586539  |e 54600PM1185586539  |k 0/50000/  |k 1/50000/54600/  |p 9 
998 |g 1034438654  |a Zimmermann, Frank  |m 1034438654:Zimmermann, Frank  |d 700000  |d 710000  |e 700000PZ1034438654  |e 710000PZ1034438654  |k 0/700000/  |k 1/700000/710000/  |p 7 
998 |g 1221305247  |a Ottenheijm, Roger  |m 1221305247:Ottenheijm, Roger  |d 50000  |d 54600  |e 50000PO1221305247  |e 54600PO1221305247  |k 0/50000/  |k 1/50000/54600/  |p 6 
998 |g 1156876850  |a Tsvilovskyy, Volodymyr  |m 1156876850:Tsvilovskyy, Volodymyr  |d 50000  |d 54600  |e 50000PT1156876850  |e 54600PT1156876850  |k 0/50000/  |k 1/50000/54600/  |p 4 
998 |g 1209243423  |a Richter, Christin  |m 1209243423:Richter, Christin  |d 50000  |d 54600  |e 50000PR1209243423  |e 54600PR1209243423  |k 0/50000/  |k 1/50000/54600/  |p 2 
998 |g 1248370023  |a Schütz, Aline  |m 1248370023:Schütz, Aline  |d 50000  |d 54600  |e 50000PS1248370023  |e 54600PS1248370023  |k 0/50000/  |k 1/50000/54600/  |p 1  |x j 
999 |a KXP-PPN1783564601  |e 4026500667 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"physDesc":[{"extent":"19 S."}],"name":{"displayForm":["Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, and Marc Freichel"]},"relHost":[{"language":["eng"],"part":{"text":"37(2021), 3, Artikel-ID 109851, Seite 1-13, e1-e6","year":"2021","issue":"3","extent":"19","volume":"37","pages":"1-13, e1-e6"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryosCell reports","type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012-","publisher":"Cell Press ; Elsevier","publisherPlace":"Maryland Heights, MO ; [New York, NY]"}],"pubHistory":["1.2012 -"],"title":[{"title_sort":"Cell reports","title":"Cell reports"}],"id":{"issn":["2211-1247"],"zdb":["2649101-1"],"eki":["684964562"]},"recId":"684964562"}],"recId":"1783564601","id":{"eki":["1783564601"],"doi":["10.1016/j.celrep.2021.109851"]},"note":["Gesehen am 24.12.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"October 19, 2021","dateIssuedKey":"2021"}],"person":[{"role":"aut","display":"Schütz, Aline","family":"Schütz","given":"Aline"},{"family":"Richter","given":"Christin","display":"Richter, Christin","role":"aut"},{"role":"aut","family":"Weissgerber","given":"Petra","display":"Weissgerber, Petra"},{"role":"aut","family":"Tsvilovskyy","given":"Volodymyr","display":"Tsvilovskyy, Volodymyr"},{"given":"Michael","family":"Hesse","display":"Hesse, Michael","role":"aut"},{"role":"aut","display":"Ottenheijm, Roger","given":"Roger","family":"Ottenheijm"},{"role":"aut","display":"Zimmermann, Frank","family":"Zimmermann","given":"Frank"},{"display":"Buchholz, Stefanie","given":"Stefanie","family":"Buchholz","role":"aut"},{"role":"aut","family":"Medert","given":"Rebekka","display":"Medert, Rebekka"},{"role":"aut","given":"Sascha","family":"Dlugosz","display":"Dlugosz, Sascha"},{"family":"Kuryshev","given":"Vladimir","display":"Kuryshev, Vladimir","role":"aut"},{"role":"aut","display":"Benes, Vladimir","family":"Benes","given":"Vladimir"},{"role":"aut","display":"Flockerzi, Veit","family":"Flockerzi","given":"Veit"},{"role":"aut","display":"Fleischmann, Bernd K.","given":"Bernd K.","family":"Fleischmann"},{"display":"Cavalié, Adolfo","given":"Adolfo","family":"Cavalié","role":"aut"},{"family":"Freichel","given":"Marc","display":"Freichel, Marc","role":"aut"}],"title":[{"title":"Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos","title_sort":"Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos"}]} 
SRT |a SCHUETZALITROPHECTOD1920 

Similar Items