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Optimization of sepsis therapy based on patient-specific digital precision diagnostics using next generation sequencing (DigiSep-Trial): study protocol for a randomized, controlled, interventional, open-label, multicenter trial

Sepsis is triggered by an infection and represents one of the greatest challenges of modern intensive care medicine. With regard to a targeted antimicrobial treatment strategy, the earliest possible pathogen detection is of crucial importance. Until now, culture-based detection methods represent the...

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Main Authors: Brenner, Thorsten (Author) , Skarabis, Annabell (Author) , Stevens, Philip (Author) , Axnick, Jennifer (Author) , Haug, Peter (Author) , Grumaz, Silke (Author) , Bruckner, Thomas (Author) , Luntz, Steffen P. (Author) , Witzke, Oliver (Author) , Pletz, Mathias W. (Author) , Ruprecht, Thomas M. (Author) , Marschall, Ursula (Author) , Altin, Sibel (Author) , Greiner, Wolfgang (Author) , Berger, Marc Moritz (Author)
Format: Article (Journal)
Language:English
Published: 18 October 2021
In: Trials
Year: 2021, Volume: 22, Pages: 1-12
ISSN:1468-6694
DOI:10.1186/s13063-021-05667-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13063-021-05667-x
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Author Notes:Thorsten Brenner, Annabell Skarabis, Philip Stevens, Jennifer Axnick, Peter Haug, Silke Grumaz, Thomas Bruckner, Steffen Luntz, Oliver Witzke, Mathias W. Pletz, Thomas M. Ruprecht, Ursula Marschall, Sibel Altin, Wolfgang Greiner, and Marc Moritz Berger for the TIFOnet Critical Care Trials Group

MARC

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