Diabetes Mellitus and its impact on patient-profile and in-hospital outcomes in peripheral artery disease
Background: In patients with peripheral artery disease (PAD), the impact of diabetes mellitus (DM) on patient-profile and adverse in-hospital events is not well investigated. Methods: The German nationwide inpatient sample 2005-2019 was used for this analysis. Hospitalized PAD patients were stratifi...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 October 2021
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| In: |
Journal of Clinical Medicine
Year: 2021, Jahrgang: 10, Heft: 21, Pages: 1-13 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10215033 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm10215033 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/10/21/5033 
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| Verfasserangaben: | Karsten Keller, Volker H. Schmitt, Markus Vosseler, Christoph Brochhausen, Thomas Münzel, Lukas Hobohm and Christine Espinola-Klein |
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| 245 | 1 | 0 | |a Diabetes Mellitus and its impact on patient-profile and in-hospital outcomes in peripheral artery disease |c Karsten Keller, Volker H. Schmitt, Markus Vosseler, Christoph Brochhausen, Thomas Münzel, Lukas Hobohm and Christine Espinola-Klein |
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| 520 | |a Background: In patients with peripheral artery disease (PAD), the impact of diabetes mellitus (DM) on patient-profile and adverse in-hospital events is not well investigated. Methods: The German nationwide inpatient sample 2005-2019 was used for this analysis. Hospitalized PAD patients were stratified for DM and the influence of DM on patient-profile and adverse in-hospital events was investigated. Results: Our study comprised 2,654,871 hospitalizations (54.3% aged ≥70 years, 36.7% females) of patients with PAD in Germany 2005-2019. Among these, 864,691 (32.6%) patients had DM and 76,716 (2.9%) died during hospitalization. Diabetic PAD patients revealed an aggravated cardiovascular profile (Charlson Comorbidity Index: 6.0 (5.0-8.0) vs. 4.0 (3.0-5.0), p < 0.001). PAD patients with DM showed a higher rate of in-hospital mortality (3.5% vs. 2.6%, p < 0.001), as well as major adverse cardiovascular and cerebrovascular events (MACCE, 4.7% vs. 3.3%, p < 0.001) and had more often operated with amputation surgery (16.4% vs. 9.1%, p < 0.001). DM was an independent predictor of in-hospital mortality (OR 1.077 (95%CI 1.060-1.093), p < 0.001) and MACCE (OR 1.118 (95%CI 1.103-1.133), p < 0.001). In addition, amputations were also associated with DM (OR 1.804 (95%CI 1.790-1.818)), p < 0.001). Conclusions: DM is associated with an unfavorable clinical patient-profile and higher risk for adverse events in PAD patients, including substantially increased in-hospital mortality as well as MACCE rate, and were more often associated with amputation surgeries. | ||
| 650 | 4 | |a amputation | |
| 650 | 4 | |a diabetes mellitus | |
| 650 | 4 | |a myocardial infarction | |
| 650 | 4 | |a peripheral artery disease | |
| 700 | 1 | |a Schmitt, Volker H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vosseler, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brochhausen, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Münzel, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hobohm, Lukas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Espinola-Klein, Christine |e VerfasserIn |4 aut | |
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