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Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via...

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Bibliographic Details
Main Authors: Rahmouni, Sabri (Author) , Lindner, Aaron (Author) , Rechenmacher, Florian (Author) , Neubauer, Stefanie (Author) , Sobahi, Tariq Rashad Ali (Author) , Kessler, Horst (Author) , Cavalcanti-Adam, Elisabetta A. (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: August 5, 2013
In: Advanced materials
Year: 2013, Volume: 25, Issue: 41, Pages: 5869-5874
ISSN:1521-4095
DOI:10.1002/adma.201301338
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/adma.201301338
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201301338
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Author Notes:Sabri Rahmouni, Aaron Lindner, Florian Rechenmacher, Stefanie Neubauer, Tariq Rashad Ali Sobahi, Horst Kessler, Elisabetta Ada Cavalcanti-Adam, Joachim Pius Spatz
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Summary:Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via α5 β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.
Item Description:Gesehen am 05.01.2022
Physical Description:Online Resource
ISSN:1521-4095
DOI:10.1002/adma.201301338

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