Sulforaphane targets TRA-1/GLI upstream of DAF-16/FOXO to promote C. elegans longevity and healthspan

Broccoli-derived isothiocyanate sulforaphane inhibits inflammation and cancer. Sulforaphane may support healthy aging, but the underlying detailed mechanisms are unclear. We used the C. elegans nematode model to address this question. Wild-type and 4 mutant C. elegans worm strains were fed in the pr...

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Bibliographic Details

Main Authors:	Ji, Huihui (Author) , Qi, Zhimin (Author) , Schrapel, Daniel (Author) , Le, Monika Thanh Ha (Author) , Luo, Yiqiao (Author) , Yan, Bin (Author) , Gladkich, Jury (Author) , Schäfer, Michael (Author) , Liu, Li (Author) , Herr, Ingrid (Author)
Format:	Article (Journal)
Language:	English
Published:	03 December 2021
In:	Frontiers in cell and developmental biology Year: 2021, Volume: 9, Pages: 1-14
ISSN:	2296-634X
DOI:	10.3389/fcell.2021.784999
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fcell.2021.784999 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fcell.2021.784999
Author Notes:	Huihui Ji, Zhimin Qi, Daniel Schrapel, Monika Le, Yiqiao Luo, Bin Yan, Jury Gladkich, Michael Schaefer, Li Liu, Ingrid Herr