Treatment and outcome of patients with metastatic NSCLC: a retrospective institution analysis of 493 patients
BACKGROUND: Most patients with metastatic non-small cell lung cancer (NSCLC) will face treatment with systemic therapy. Current clinical studies are demonstrating improvements in chemotherapy and overall survival. However, it remains unclear whether these results are translated into clinical practic...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 December 2013
|
| In: |
Respiratory research
Year: 2013, Jahrgang: 14, Pages: 1-9 |
| ISSN: | 1465-993X |
| DOI: | 10.1186/1465-9921-14-139 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1465-9921-14-139 Verlag, lizenzpflichtig, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-14-139 
|
| Verfasserangaben: | Niels Reinmuth, Nadine Payer, Thomas Muley, Hans Hoffmann, Felix Jf Herth, Matthias Villalobos and Michael Thomas |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1785194801 | ||
| 003 | DE-627 | ||
| 005 | 20240415193251.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220107s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/1465-9921-14-139 |2 doi | |
| 035 | |a (DE-627)1785194801 | ||
| 035 | |a (DE-599)KXP1785194801 | ||
| 035 | |a (OCoLC)1341436586 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Reinmuth, Niels |d 1970- |e VerfasserIn |0 (DE-588)122316592 |0 (DE-627)705858936 |0 (DE-576)293216266 |4 aut | |
| 245 | 1 | 0 | |a Treatment and outcome of patients with metastatic NSCLC |b a retrospective institution analysis of 493 patients |c Niels Reinmuth, Nadine Payer, Thomas Muley, Hans Hoffmann, Felix Jf Herth, Matthias Villalobos and Michael Thomas |
| 264 | 1 | |c 18 December 2013 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.01.2022 | ||
| 500 | |a DOI funktioniert nicht | ||
| 520 | |a BACKGROUND: Most patients with metastatic non-small cell lung cancer (NSCLC) will face treatment with systemic therapy. Current clinical studies are demonstrating improvements in chemotherapy and overall survival. However, it remains unclear whether these results are translated into clinical practice. - METHODS: We reviewed all stage IV NSCLC patients without second malignancies that were diagnosed from 2004 to 2006 at our institution. 493 consecutive patients were included into this retrospective analysis and were followed-up until end of 2011. - RESULTS: 352 patients (71.4%) received systemic therapy for up to 7 lines. For most patients, adjustments of dosages or applications had to be made at some point of the treatment, but the total applied dose remained generally close to the intended dose. The best disease control (BDC) rate decreased with increasing therapy lines from 59.7% to about 35%. Patients with palliative local therapy but no systemic treatment demonstrated inferior survival (median 2.9 versus 8.7 months, p < 0.001). The median interval between last treatment and death was 50 days and 15 days for chemotherapy and anti-EGFR therapy, respectively. BDC to the previous therapy lines was predictive for improved BDC to third- but not second-line therapy. Performing multivariate analysis, BDC to previous therapy, never-/ former-smoking status, and age > 70 years were associated with improved survival performing third-line therapy. - CONCLUSIONS: Stage IV NSCLC patients may receive substantial systemic therapy resulting in response and median survival rates that are comparable to data from clinical studies. However, preselection factors are increasingly important to improve therapy outcome and life quality. | ||
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Antineoplastic Agents | |
| 650 | 4 | |a Carcinoma, Non-Small-Cell Lung | |
| 650 | 4 | |a Dose-Response Relationship, Drug | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Follow-Up Studies | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Lung Neoplasms | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Multivariate Analysis | |
| 650 | 4 | |a Neoplasm Metastasis | |
| 650 | 4 | |a Neoplasm Staging | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Retrospective Studies | |
| 650 | 4 | |a Survival Rate | |
| 650 | 4 | |a Treatment Outcome | |
| 700 | 1 | |a Payer, Nadine |d 1983- |e VerfasserIn |0 (DE-588)1052143644 |0 (DE-627)78792377X |0 (DE-576)40790462X |4 aut | |
| 700 | 1 | |a Muley, Thomas |e VerfasserIn |0 (DE-588)1056885432 |0 (DE-627)794179169 |0 (DE-576)16759284X |4 aut | |
| 700 | 1 | |a Hoffmann, Hans |d 1957- |e VerfasserIn |0 (DE-588)1022900455 |0 (DE-627)71732852X |0 (DE-576)366147730 |4 aut | |
| 700 | 1 | |a Herth, Felix |e VerfasserIn |0 (DE-588)1016095236 |0 (DE-627)705477568 |0 (DE-576)351509925 |4 aut | |
| 700 | 1 | |a Villalobos Bollen, Matthias Americo |d 1974- |e VerfasserIn |0 (DE-588)1078644306 |0 (DE-627)839010133 |0 (DE-576)451580516 |4 aut | |
| 700 | 1 | |a Thomas, Michael |e VerfasserIn |0 (DE-588)1054438781 |0 (DE-627)79152213X |0 (DE-576)41027089X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Respiratory research |d London : BioMed Central, 2001 |g 14(2013), Artikel-ID 139, Seite 1-9 |h Online-Ressource |w (DE-627)326646485 |w (DE-600)2041675-1 |w (DE-576)107014823 |x 1465-993X |7 nnas |a Treatment and outcome of patients with metastatic NSCLC a retrospective institution analysis of 493 patients |
| 773 | 1 | 8 | |g volume:14 |g year:2013 |g elocationid:139 |g pages:1-9 |g extent:9 |a Treatment and outcome of patients with metastatic NSCLC a retrospective institution analysis of 493 patients |
| 856 | 4 | 0 | |u https://doi.org/10.1186/1465-9921-14-139 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-14-139 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220107 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1054438781 |a Thomas, Michael |m 1054438781:Thomas, Michael |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PT1054438781 |e 950000PT1054438781 |e 950900PT1054438781 |e 50000PT1054438781 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 7 |y j | ||
| 998 | |g 1078644306 |a Villalobos Bollen, Matthias Americo |m 1078644306:Villalobos Bollen, Matthias Americo |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PV1078644306 |e 950000PV1078644306 |e 950900PV1078644306 |e 50000PV1078644306 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 6 | ||
| 998 | |g 1016095236 |a Herth, Felix |m 1016095236:Herth, Felix |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PH1016095236 |e 950000PH1016095236 |e 950900PH1016095236 |e 50000PH1016095236 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 5 | ||
| 998 | |g 1022900455 |a Hoffmann, Hans |m 1022900455:Hoffmann, Hans |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PH1022900455 |e 950000PH1022900455 |e 950900PH1022900455 |e 50000PH1022900455 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 4 | ||
| 998 | |g 1056885432 |a Muley, Thomas |m 1056885432:Muley, Thomas |d 910000 |d 950000 |d 950900 |e 910000PM1056885432 |e 950000PM1056885432 |e 950900PM1056885432 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 3 | ||
| 998 | |g 1052143644 |a Payer, Nadine |m 1052143644:Payer, Nadine |d 910000 |d 950000 |d 950900 |e 910000PP1052143644 |e 950000PP1052143644 |e 950900PP1052143644 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 2 | ||
| 998 | |g 122316592 |a Reinmuth, Niels |m 122316592:Reinmuth, Niels |d 50000 |e 50000PR122316592 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1785194801 |e 4030902650 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"note":["Gesehen am 04.08.22"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"326646485","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2000 -"],"language":["eng"],"disp":"Treatment and outcome of patients with metastatic NSCLC a retrospective institution analysis of 493 patientsRespiratory research","title":[{"title":"Respiratory research","title_sort":"Respiratory research"}],"origin":[{"dateIssuedDisp":"2001-","publisherPlace":"London","dateIssuedKey":"2001","publisher":"BioMed Central"}],"id":{"zdb":["2041675-1"],"eki":["326646485"],"issn":["1465-993X"]},"part":{"year":"2013","text":"14(2013), Artikel-ID 139, Seite 1-9","extent":"9","pages":"1-9","volume":"14"}}],"physDesc":[{"extent":"9 S."}],"recId":"1785194801","note":["Gesehen am 07.01.2022","DOI funktioniert nicht"],"language":["eng"],"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"18 December 2013"}],"id":{"eki":["1785194801"],"doi":["10.1186/1465-9921-14-139"]},"person":[{"given":"Niels","display":"Reinmuth, Niels","role":"aut","family":"Reinmuth"},{"family":"Payer","display":"Payer, Nadine","role":"aut","given":"Nadine"},{"given":"Thomas","family":"Muley","role":"aut","display":"Muley, Thomas"},{"given":"Hans","display":"Hoffmann, Hans","role":"aut","family":"Hoffmann"},{"family":"Herth","role":"aut","display":"Herth, Felix","given":"Felix"},{"given":"Matthias Americo","family":"Villalobos Bollen","display":"Villalobos Bollen, Matthias Americo","role":"aut"},{"given":"Michael","family":"Thomas","display":"Thomas, Michael","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Niels Reinmuth, Nadine Payer, Thomas Muley, Hans Hoffmann, Felix Jf Herth, Matthias Villalobos and Michael Thomas"]},"title":[{"subtitle":"a retrospective institution analysis of 493 patients","title":"Treatment and outcome of patients with metastatic NSCLC","title_sort":"Treatment and outcome of patients with metastatic NSCLC"}]} | ||
| SRT | |a REINMUTHNITREATMENTA1820 | ||