Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas
High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in the...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 December 2013
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| In: |
Genome biology
Year: 2013, Jahrgang: 14, Heft: 12, Pages: 1-26 |
| ISSN: | 1474-760X |
| DOI: | 10.1186/gb-2013-14-12-r137 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/gb-2013-14-12-r137 Verlag, lizenzpflichtig, Volltext: https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-12-r137 
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| Verfasserangaben: | Marcus Renner, Thomas Wolf, Hannah Meyer, Wolfgang Hartmann, Roland Penzel, Alexis Ulrich, Burkhard Lehner, Volker Hovestadt, Esteban Czwan, Gerlinde Egerer, Thomas Schmitt, Ingo Alldinger, Eva Kristin Renker, Volker Ehemann, Roland Eils, Eva Wardelmann, Reinhard Büttner, Peter Lichter, Benedikt Brors, Peter Schirmacher and Gunhild Mechtersheimer |
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| 520 | |a High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in these tumors is not well understood and, consequently, the usefulness of methylation-based classification is unclear. | ||
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