Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation
Background - Chromosomal abnormalities have been shown to play a major role in disease evolution of multiple myeloma. Specific changes in interphase cells can be detected by fluorescent in situ hybridization, which overcomes the problem of the lack of dividing cells required for conventional cytogen...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010 Jul
|
| In: |
Haematologica, the hematology journal
Year: 2010, Jahrgang: 95, Heft: 7, Pages: 1150-1157 |
| ISSN: | 1592-8721 |
| DOI: | 10.3324/haematol.2009.016436 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.2009.016436 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895040/ 
|
| Verfasserangaben: | Kai Neben, Anna Jauch, Uta Bertsch, Christiane Heiss, Thomas Hielscher, Anja Seckinger, Tina Mors, Nadine Zoe Müller, Jens Hillengass, Marc S. Raab, Anthony D. Ho, Dirk Hose, and Hartmut Goldschmidt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 178523756X | ||
| 003 | DE-627 | ||
| 005 | 20240411120707.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220107s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3324/haematol.2009.016436 |2 doi | |
| 035 | |a (DE-627)178523756X | ||
| 035 | |a (DE-599)KXP178523756X | ||
| 035 | |a (OCoLC)1341436872 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Neben, Kai |d 1969- |e VerfasserIn |0 (DE-588)120842181 |0 (DE-627)080920470 |0 (DE-576)292411774 |4 aut | |
| 245 | 1 | 0 | |a Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation |c Kai Neben, Anna Jauch, Uta Bertsch, Christiane Heiss, Thomas Hielscher, Anja Seckinger, Tina Mors, Nadine Zoe Müller, Jens Hillengass, Marc S. Raab, Anthony D. Ho, Dirk Hose, and Hartmut Goldschmidt |
| 264 | 1 | |c 2010 Jul | |
| 300 | |b Diagramme | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.01.2022 | ||
| 520 | |a Background - Chromosomal abnormalities have been shown to play a major role in disease evolution of multiple myeloma. Specific changes in interphase cells can be detected by fluorescent in situ hybridization, which overcomes the problem of the lack of dividing cells required for conventional cytogenetics. - - Design and Methods - We analyzed the prognostic value of 12 frequent chromosomal abnormalities detected by fluorescent in situ hybridization in a series of patients (n=315) with newly diagnosed, symptomatic multiple myeloma. All patients underwent frontline autologous stem cell transplantation according to the GMMG-HD3- or GMMG-HD4-trial protocols or analogous protocols. - - Results - Univariate statistical analyses revealed that the presence of del(13q14), del(17p13), t(4;14), +1q21 and non-hyperdiploidy was associated with adverse progression-free and overall survival rates independently of the International Staging System (ISS) classification. Multivariate analyses showed that only t(4;14) and del(17p13) retained prognostic value for both progression-free and overall survival. According to the presence or absence of t(4;14) and del(17p13) and the patients’ International Staging System classification, the cohort could be stratified into three distinct groups: a group with a favorable prognosis [absence of t(4;14)/del(17p13) and ISS I], a group with a poor prognosis [presence of t(4;14)/del(17p13) and ISS II/III] and a group with an intermediate prognosis (all remaining patients). The probabilities of overall survival at 5 years decreased from 72% in the favorable prognostic group to 62% (hazard ratio 2.4; P=0.01) in the intermediate and 41% (hazard ratio 5.6; P<0.001) in the poor prognostic groups. - - Conclusions - These results have implications for risk-adapted management for patients with multiple myeloma undergoing high-dose chemotherapy followed by autologous stem cell transplantation and suggest that new treatment concepts are urgently needed for patients who belong to the poor prognosis group. As targeted therapies evolve, different treatment options might have variable success, depending on the underlying genetic nature of the clone. | ||
| 700 | 1 | |a Jauch, Anna |d 1959- |e VerfasserIn |0 (DE-588)1025525140 |0 (DE-627)722525362 |0 (DE-576)168357496 |4 aut | |
| 700 | 1 | |a Bertsch, Uta |e VerfasserIn |0 (DE-588)1026849861 |0 (DE-627)727494163 |0 (DE-576)372176224 |4 aut | |
| 700 | 1 | |a Heiß, Christiane |d 1976- |e VerfasserIn |0 (DE-588)1060030764 |0 (DE-627)79917131X |0 (DE-576)416132537 |4 aut | |
| 700 | 1 | |a Hielscher, Thomas |e VerfasserIn |0 (DE-588)1159594791 |0 (DE-627)1022977768 |0 (DE-576)50506068X |4 aut | |
| 700 | 1 | |a Seckinger, Anja |d 1980- |e VerfasserIn |0 (DE-588)134177371 |0 (DE-627)562118225 |0 (DE-576)278603734 |4 aut | |
| 700 | 1 | |a Mors, Tina Margarete |d 1982- |e VerfasserIn |0 (DE-588)144017806 |0 (DE-627)656814357 |0 (DE-576)340358602 |4 aut | |
| 700 | 1 | |a Müller, Nadine Zoé |d 1981- |e VerfasserIn |0 (DE-588)141457082 |0 (DE-627)627795722 |0 (DE-576)323590365 |4 aut | |
| 700 | 1 | |a Hillengaß, Jens |d 1974- |e VerfasserIn |0 (DE-588)124918549 |0 (DE-627)368073823 |0 (DE-576)294568298 |4 aut | |
| 700 | 1 | |a Raab, Marc-Steffen |d 1973- |e VerfasserIn |0 (DE-588)124052460 |0 (DE-627)706520998 |0 (DE-576)293998027 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Hose, Dirk |d 1969- |e VerfasserIn |0 (DE-588)139824995 |0 (DE-627)613790308 |0 (DE-576)313431698 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Haematologica, the hematology journal |d Pavia : Ferrata Storti Foundation, 2005 |g 95(2010), 7, Seite 1150-1157 |h Online-Ressource |w (DE-627)48524375X |w (DE-600)2186022-1 |w (DE-576)414771095 |x 1592-8721 |7 nnas |a Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation |
| 773 | 1 | 8 | |g volume:95 |g year:2010 |g number:7 |g pages:1150-1157 |g extent:8 |a Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.3324/haematol.2009.016436 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895040/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220107 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 13 |y j | ||
| 998 | |g 139824995 |a Hose, Dirk |m 139824995:Hose, Dirk |d 910000 |d 910100 |e 910000PH139824995 |e 910100PH139824995 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 124052460 |a Raab, Marc-Steffen |m 124052460:Raab, Marc-Steffen |d 910000 |d 910100 |e 910000PR124052460 |e 910100PR124052460 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 124918549 |a Hillengaß, Jens |m 124918549:Hillengaß, Jens |d 910000 |d 910100 |e 910000PH124918549 |e 910100PH124918549 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 141457082 |a Müller, Nadine Zoé |m 141457082:Müller, Nadine Zoé |d 50000 |e 50000PM141457082 |k 0/50000/ |p 8 | ||
| 998 | |g 144017806 |a Mors, Tina Margarete |m 144017806:Mors, Tina Margarete |d 50000 |e 50000PM144017806 |k 0/50000/ |p 7 | ||
| 998 | |g 134177371 |a Seckinger, Anja |m 134177371:Seckinger, Anja |d 910000 |d 910100 |e 910000PS134177371 |e 910100PS134177371 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1159594791 |a Hielscher, Thomas |m 1159594791:Hielscher, Thomas |d 140000 |e 140000PH1159594791 |k 0/140000/ |p 5 | ||
| 998 | |g 1060030764 |a Heiß, Christiane |m 1060030764:Heiß, Christiane |d 910000 |d 910100 |e 910000PH1060030764 |e 910100PH1060030764 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1026849861 |a Bertsch, Uta |m 1026849861:Bertsch, Uta |d 910000 |d 910100 |e 910000PB1026849861 |e 910100PB1026849861 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1025525140 |a Jauch, Anna |m 1025525140:Jauch, Anna |d 910000 |d 911500 |d 50000 |e 910000PJ1025525140 |e 911500PJ1025525140 |e 50000PJ1025525140 |k 0/910000/ |k 1/910000/911500/ |k 0/50000/ |p 2 | ||
| 998 | |g 120842181 |a Neben, Kai |m 120842181:Neben, Kai |d 50000 |e 50000PN120842181 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN178523756X |e 4031249519 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"display":"Neben, Kai","family":"Neben","given":"Kai","role":"aut"},{"family":"Jauch","display":"Jauch, Anna","role":"aut","given":"Anna"},{"given":"Uta","role":"aut","family":"Bertsch","display":"Bertsch, Uta"},{"display":"Heiß, Christiane","family":"Heiß","given":"Christiane","role":"aut"},{"display":"Hielscher, Thomas","family":"Hielscher","role":"aut","given":"Thomas"},{"given":"Anja","role":"aut","family":"Seckinger","display":"Seckinger, Anja"},{"given":"Tina Margarete","role":"aut","display":"Mors, Tina Margarete","family":"Mors"},{"role":"aut","given":"Nadine Zoé","display":"Müller, Nadine Zoé","family":"Müller"},{"role":"aut","given":"Jens","family":"Hillengaß","display":"Hillengaß, Jens"},{"given":"Marc-Steffen","role":"aut","display":"Raab, Marc-Steffen","family":"Raab"},{"family":"Ho","display":"Ho, Anthony Dick","role":"aut","given":"Anthony Dick"},{"family":"Hose","display":"Hose, Dirk","role":"aut","given":"Dirk"},{"family":"Goldschmidt","display":"Goldschmidt, Hartmut","given":"Hartmut","role":"aut"}],"id":{"doi":["10.3324/haematol.2009.016436"],"eki":["178523756X"]},"name":{"displayForm":["Kai Neben, Anna Jauch, Uta Bertsch, Christiane Heiss, Thomas Hielscher, Anja Seckinger, Tina Mors, Nadine Zoe Müller, Jens Hillengass, Marc S. Raab, Anthony D. Ho, Dirk Hose, and Hartmut Goldschmidt"]},"physDesc":[{"extent":"8 S.","noteIll":"Diagramme"}],"relHost":[{"id":{"zdb":["2186022-1"],"issn":["1592-8721"],"eki":["48524375X"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"48524375X","disp":"Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantationHaematologica, the hematology journal","type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"Haematologica, the hematology journal","title_sort":"Haematologica, the hematology journal","subtitle":"official organ of the European Hematology Association"}],"note":["Gesehen am 27.09.2018"],"origin":[{"dateIssuedKey":"2005","publisher":"Ferrata Storti Foundation","dateIssuedDisp":"2005-2013","publisherPlace":"Pavia"}],"pubHistory":["90.2005 - 98.2013"],"part":{"year":"2010","pages":"1150-1157","text":"95(2010), 7, Seite 1150-1157","issue":"7","volume":"95","extent":"8"},"language":["eng"]}],"recId":"178523756X","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 07.01.2022"],"origin":[{"dateIssuedDisp":"2010 Jul","dateIssuedKey":"2010"}],"title":[{"title":"Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation","title_sort":"Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation"}]} | ||
| SRT | |a NEBENKAIJACOMBININGI2010 | ||