Vancomycin resistance is overcome by conjugation of polycationic peptides
Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized.
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
|
| In: |
Angewandte Chemie. International edition
Year: 2020, Volume: 59, Issue: 23, Pages: 8823-8827 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.202002727 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/anie.202002727 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/anie.202002727 
|
| Author Notes: | Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, Stefan Zimmermann, Barbro Beijer, Karel D. Klika, Uwe Haberkorn, Walter Mier, and Philipp Uhl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 178541254X | ||
| 003 | DE-627 | ||
| 005 | 20230427062103.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220111s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/anie.202002727 |2 doi | |
| 035 | |a (DE-627)178541254X | ||
| 035 | |a (DE-599)KXP178541254X | ||
| 035 | |a (OCoLC)1295679902 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Umstätter, Florian |d 1991- |e VerfasserIn |0 (DE-588)1201610044 |0 (DE-627)1685679625 |4 aut | |
| 245 | 1 | 0 | |a Vancomycin resistance is overcome by conjugation of polycationic peptides |c Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, Stefan Zimmermann, Barbro Beijer, Karel D. Klika, Uwe Haberkorn, Walter Mier, and Philipp Uhl |
| 264 | 1 | |c 2020 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Version of record online: April 21, 2020 | ||
| 500 | |a Gesehen am 11.02.2022 | ||
| 520 | |a Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized. | ||
| 700 | 1 | |a Domhan, Cornelius |e VerfasserIn |0 (DE-588)116216123X |0 (DE-627)1025608933 |0 (DE-576)507236130 |4 aut | |
| 700 | 1 | |a Hertlein, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ohlsen, Knut |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mühlberg, Eric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kleist, Christian |e VerfasserIn |0 (DE-588)138977410 |0 (DE-627)703170287 |0 (DE-576)309272971 |4 aut | |
| 700 | 1 | |a Zimmermann, Stefan |d 1968- |e VerfasserIn |0 (DE-588)129100846 |0 (DE-627)389531790 |0 (DE-576)297493612 |4 aut | |
| 700 | 1 | |a Beijer, Barbro |e VerfasserIn |0 (DE-588)1058353705 |0 (DE-627)796731713 |0 (DE-576)186718780 |4 aut | |
| 700 | 1 | |a Klika, Karel D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Mier, Walter |d 1966- |e VerfasserIn |0 (DE-588)12029026X |0 (DE-627)69653567X |0 (DE-576)292141599 |4 aut | |
| 700 | 1 | |a Uhl, Philipp |e VerfasserIn |0 (DE-588)1112349391 |0 (DE-627)866420797 |0 (DE-576)476575230 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Angewandte Chemie. International edition |d Weinheim : Wiley-VCH, 1998 |g 59(2020), 23, Seite 8823-8827 |h Online-Ressource |w (DE-627)320497879 |w (DE-600)2011836-3 |w (DE-576)111552060 |x 1521-3773 |7 nnas |a Vancomycin resistance is overcome by conjugation of polycationic peptides |
| 773 | 1 | 8 | |g volume:59 |g year:2020 |g number:23 |g pages:8823-8827 |g extent:5 |a Vancomycin resistance is overcome by conjugation of polycationic peptides |
| 775 | 0 | 8 | |i Parallele Sprachausgabe |n deutsch |a Umstätter, Florian, 1991 - |t Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden |d 2020 |w (DE-627)1785417983 |
| 787 | 0 | 8 | |i Errata |a Umstätter, Florian, 1991 - |t Vancomycin resistance is overcome by conjugation of polycationic peptides |d 2020 |w (DE-627)1785415301 |
| 856 | 4 | 0 | |u https://doi.org/10.1002/anie.202002727 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/10.1002/anie.202002727 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220111 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1112349391 |a Uhl, Philipp |m 1112349391:Uhl, Philipp |d 910000 |d 911400 |e 910000PU1112349391 |e 911400PU1112349391 |k 0/910000/ |k 1/910000/911400/ |p 12 |y j | ||
| 998 | |g 12029026X |a Mier, Walter |m 12029026X:Mier, Walter |d 910000 |d 911400 |d 140000 |e 910000PM12029026X |e 911400PM12029026X |e 140000PM12029026X |k 0/910000/ |k 1/910000/911400/ |k 0/140000/ |p 11 | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 10 | ||
| 998 | |g 1058353705 |a Beijer, Barbro |m 1058353705:Beijer, Barbro |d 50000 |e 50000PB1058353705 |k 0/50000/ |p 8 | ||
| 998 | |g 129100846 |a Zimmermann, Stefan |m 129100846:Zimmermann, Stefan |d 910000 |d 911700 |e 910000PZ129100846 |e 911700PZ129100846 |k 0/910000/ |k 1/910000/911700/ |p 7 | ||
| 998 | |g 138977410 |a Kleist, Christian |m 138977410:Kleist, Christian |d 910000 |d 911400 |e 910000PK138977410 |e 911400PK138977410 |k 0/910000/ |k 1/910000/911400/ |p 6 | ||
| 998 | |g 116216123X |a Domhan, Cornelius |m 116216123X:Domhan, Cornelius |d 160000 |d 160100 |e 160000PD116216123X |e 160100PD116216123X |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 998 | |g 1201610044 |a Umstätter, Florian |m 1201610044:Umstätter, Florian |d 910000 |d 911400 |e 910000PU1201610044 |e 911400PU1201610044 |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN178541254X |e 403275277X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"5 S."}],"id":{"eki":["178541254X"],"doi":["10.1002/anie.202002727"]},"title":[{"title_sort":"Vancomycin resistance is overcome by conjugation of polycationic peptides","title":"Vancomycin resistance is overcome by conjugation of polycationic peptides"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"2020"}],"relHost":[{"pubHistory":["37.1998 -"],"note":["Gesehen am 20.12.2022","Fortsetzung der Druck-Ausgabe"],"part":{"year":"2020","volume":"59","text":"59(2020), 23, Seite 8823-8827","extent":"5","pages":"8823-8827","issue":"23"},"language":["eng"],"titleAlt":[{"title":"Angewandte Chemie / International edition"}],"disp":"Vancomycin resistance is overcome by conjugation of polycationic peptidesAngewandte Chemie. International edition","type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"role":"isb","display":"Gesellschaft Deutscher Chemiker"}],"recId":"320497879","origin":[{"publisher":"Wiley-VCH","dateIssuedDisp":"1998-","dateIssuedKey":"1998","publisherPlace":"Weinheim"}],"id":{"doi":["10.1002/(ISSN)1521-3773"],"zdb":["2011836-3"],"issn":["1521-3773"],"eki":["320497879"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Angewandte Chemie","subtitle":"a journal of the Gesellschaft Deutscher Chemiker","title_sort":"Angewandte Chemie","partname":"International edition"}]}],"language":["eng"],"name":{"displayForm":["Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg, Christian Kleist, Stefan Zimmermann, Barbro Beijer, Karel D. Klika, Uwe Haberkorn, Walter Mier, and Philipp Uhl"]},"note":["Version of record online: April 21, 2020","Gesehen am 11.02.2022"],"recId":"178541254X","person":[{"given":"Florian","display":"Umstätter, Florian","family":"Umstätter","role":"aut"},{"display":"Domhan, Cornelius","given":"Cornelius","family":"Domhan","role":"aut"},{"role":"aut","family":"Hertlein","display":"Hertlein, Tobias","given":"Tobias"},{"given":"Knut","display":"Ohlsen, Knut","role":"aut","family":"Ohlsen"},{"family":"Mühlberg","role":"aut","display":"Mühlberg, Eric","given":"Eric"},{"family":"Kleist","role":"aut","given":"Christian","display":"Kleist, Christian"},{"given":"Stefan","display":"Zimmermann, Stefan","role":"aut","family":"Zimmermann"},{"given":"Barbro","display":"Beijer, Barbro","role":"aut","family":"Beijer"},{"family":"Klika","role":"aut","given":"Karel D.","display":"Klika, Karel D."},{"given":"Uwe","display":"Haberkorn, Uwe","role":"aut","family":"Haberkorn"},{"role":"aut","family":"Mier","display":"Mier, Walter","given":"Walter"},{"role":"aut","family":"Uhl","display":"Uhl, Philipp","given":"Philipp"}]} | ||
| SRT | |a UMSTAETTERVANCOMYCIN2020 | ||