Vancomycin resistance is overcome by conjugation of polycationic peptides
Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
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| In: |
Angewandte Chemie. International edition
Year: 2020, Jahrgang: 59, Heft: 40, Pages: 17326 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.202007022 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/anie.202007022 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/anie.202007022 
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| Verfasserangaben: | F. Umstätter, C. Domhan, T. Hertlein, K. Ohlsen, E. Mühlberg, C. Kleist, S. Zimmermann, B. Beijer, K.D. Klika, U. Haberkorn, W. Mier, P. Uhl |
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| 520 | |a Resistance is futile: By site-specific conjugation polycationic peptides were conjugated to vancomycin. Derivatives that bear the peptide moiety at four different sites of the antibiotic were synthesized. | ||
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