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Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug-drug interactions with different perpetrator drugs

Aims - Using 3 different perpetrators the impact of voriconazole, cobicistat and rifampicin (single dose), we evaluated the suitability of a microdose cocktail of factor Xa inhibitors (FXaI; rivaroxaban, apixaban and edoxaban; 100 μg in total) to study drug–drug interactions.

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Bibliographic Details
Main Authors: Mikus, Gerd (Author) , Foerster, Kathrin (Author) , Schaumäker, Marlene (Author) , Lehmann, Marie-Louise (Author) , Burhenne, Jürgen (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: British journal of clinical pharmacology
Year: 2020, Volume: 86, Issue: 8, Pages: 1632-1641
ISSN:1365-2125
DOI:10.1111/bcp.14277
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/bcp.14277
Verlag, kostenfrei, Volltext: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14277
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Author Notes:Gerd Mikus, Kathrin I. Foerster, Marlene Schaumaeker, Marie-Louise Lehmann, Jürgen Burhenne, Walter E. Haefeli

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