Comparison of different lymphoma cell purging modalities: an experimental study with K422 lymphoma cells
Blood-derived autografts from patients with non-Hodgkin’s lymphoma (NHL) are frequently contaminated with clonogenic lymphoma cells. In order to obtain a more efficient lymphoma cell depletion from the transplants we compared the efficiency of different purging techniques: B-cell-directed depletion,...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 22, 1999
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| In: |
Acta haematologica
Year: 1999, Jahrgang: 101, Heft: 4, Pages: 185-192 |
| ISSN: | 1421-9662 |
| DOI: | 10.1159/000040951 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1159/000040951 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/40951 |
| Verfasserangaben: | P. Hundsdörfer, S. Fruehauf, M. Haberkorn, R. Höft, R. Haas, W. J. Zeller |
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| 520 | |a Blood-derived autografts from patients with non-Hodgkin’s lymphoma (NHL) are frequently contaminated with clonogenic lymphoma cells. In order to obtain a more efficient lymphoma cell depletion from the transplants we compared the efficiency of different purging techniques: B-cell-directed depletion, CD34+ selection by immunomagnetic beads (IMB selection) or by immunoadsorption with a biotin-avidin column (BAC selection). Furthermore, two combination approaches were investigated: IMB selection after B-cell depletion as well as BAC selection after B-cell depletion. | ||
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