Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo
The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor causally related to the pathogenesis of acute and chronic inflammation. In a mouse model of inflammation-driven skin carcinogenesis, RAGE deletion conferred protection from the development of skin tumors due to...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 May 2013
|
| In: |
The journal of investigative dermatology
Year: 2013, Jahrgang: 133, Heft: 10, Pages: 2400-2406 |
| ISSN: | 1523-1747 |
| DOI: | 10.1038/jid.2013.185 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/jid.2013.185 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022202X15359996 
|
| Verfasserangaben: | Julia S. Leibold, Astrid Riehl, Jan Hettinger, Michael Durben, Jochen Hess and Peter Angel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1785831119 | ||
| 003 | DE-627 | ||
| 005 | 20220820104456.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220112s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/jid.2013.185 |2 doi | |
| 035 | |a (DE-627)1785831119 | ||
| 035 | |a (DE-599)KXP1785831119 | ||
| 035 | |a (OCoLC)1341436817 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Leibold, Julia |e VerfasserIn |0 (DE-588)1029959072 |0 (DE-627)734530617 |0 (DE-576)377778753 |4 aut | |
| 245 | 1 | 0 | |a Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo |c Julia S. Leibold, Astrid Riehl, Jan Hettinger, Michael Durben, Jochen Hess and Peter Angel |
| 264 | 1 | |c 16 May 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.01.2022 | ||
| 520 | |a The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor causally related to the pathogenesis of acute and chronic inflammation. In a mouse model of inflammation-driven skin carcinogenesis, RAGE deletion conferred protection from the development of skin tumors due to a severely impaired cutaneous inflammation. Although the impact of RAGE expression in immune cells was shown to be essential for the maintenance of a cutaneous inflammatory reaction, the role of RAGE in keratinocytes remained unsolved. Using mice harboring a keratinocyte-specific deletion of RAGE, we analyzed its role in the regulation of an acute inflammatory response that was induced by topical treatment of the back skin with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We show that RAGE expression in cutaneous keratinocytes modulates the strength and kinetics of acute inflammation and supports the maintenance of epidermal keratinocyte activation. To address the underlying molecular mechanism, we isolated interfollicular epidermis by laser microdissection for gene expression analysis, and identified RAGE as a regulator in the temporal control of TPA-induced epidermal tumor necrosis factor alpha transcript levels. In summary, our data demonstrate that RAGE expression in keratinocytes is critically involved in the perpetuation of acute inflammation and support the central role of RAGE in paracrine communication between keratinocytes and stromal immune cells. | ||
| 700 | 1 | |a Riehl, Astrid |e VerfasserIn |0 (DE-588)139965408 |0 (DE-627)614739454 |0 (DE-576)31399532X |4 aut | |
| 700 | 1 | |a Hettinger, Jan |e VerfasserIn |0 (DE-588)1044943599 |0 (DE-627)773147179 |0 (DE-576)398242380 |4 aut | |
| 700 | 1 | |a Durben, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heß, Jochen |d 1971- |e VerfasserIn |0 (DE-588)121902390 |0 (DE-627)705696057 |0 (DE-576)292983417 |4 aut | |
| 700 | 1 | |a Angel, Peter |e VerfasserIn |0 (DE-588)1080056572 |0 (DE-627)843623179 |0 (DE-576)453297668 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of investigative dermatology |d Amsterdam : Elsevier, 1938 |g 133(2013), 10 vom: Okt., Seite 2400-2406 |h Online-Ressource |w (DE-627)320457990 |w (DE-600)2006902-9 |w (DE-576)09114289X |x 1523-1747 |7 nnas |a Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo |
| 773 | 1 | 8 | |g volume:133 |g year:2013 |g number:10 |g month:10 |g pages:2400-2406 |g extent:7 |a Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo |
| 856 | 4 | 0 | |u https://doi.org/10.1038/jid.2013.185 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0022202X15359996 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220112 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1080056572 |a Angel, Peter |m 1080056572:Angel, Peter |d 50000 |e 50000PA1080056572 |k 0/50000/ |p 6 |y j | ||
| 998 | |g 121902390 |a Heß, Jochen |m 121902390:Heß, Jochen |d 910000 |d 911000 |e 910000PH121902390 |e 911000PH121902390 |k 0/910000/ |k 1/910000/911000/ |p 5 | ||
| 998 | |g 1044943599 |a Hettinger, Jan |m 1044943599:Hettinger, Jan |d 140000 |e 140000PH1044943599 |k 0/140000/ |p 3 | ||
| 998 | |g 139965408 |a Riehl, Astrid |m 139965408:Riehl, Astrid |p 2 | ||
| 998 | |g 1029959072 |a Leibold, Julia |m 1029959072:Leibold, Julia |p 1 |x j | ||
| 999 | |a KXP-PPN1785831119 |e 4033956018 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"pubHistory":["1.1938 -"],"note":["Gesehen am 16.02.16"],"part":{"issue":"10","pages":"2400-2406","extent":"7","text":"133(2013), 10 vom: Okt., Seite 2400-2406","volume":"133","year":"2013"},"language":["eng"],"titleAlt":[{"title":"an international journal for research in cutaneous biology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivoThe journal of investigative dermatology","corporate":[{"role":"isb","display":"Society for Investigative Dermatology"}],"recId":"320457990","name":{"displayForm":["Society for Investigative Dermatology ; European Society for Dermatological Research"]},"origin":[{"dateIssuedKey":"1938","publisherPlace":"Amsterdam ; Oxford [u.a.] ; [Erscheinungsort nicht ermittelbar] ; Basingstoke [u.a.]","publisher":"Elsevier ; Blackwell ; Wiley-Blackwell ; Nature Publishing Group","dateIssuedDisp":"1938-"}],"id":{"eki":["320457990"],"issn":["1523-1747"],"zdb":["2006902-9"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"The journal of investigative dermatology","title_sort":"journal of investigative dermatology"}]}],"origin":[{"dateIssuedDisp":"16 May 2013","dateIssuedKey":"2013"}],"title":[{"title_sort":"Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo","title":"Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"7 S."}],"id":{"doi":["10.1038/jid.2013.185"],"eki":["1785831119"]},"recId":"1785831119","person":[{"family":"Leibold","role":"aut","given":"Julia","display":"Leibold, Julia"},{"family":"Riehl","role":"aut","given":"Astrid","display":"Riehl, Astrid"},{"role":"aut","family":"Hettinger","given":"Jan","display":"Hettinger, Jan"},{"display":"Durben, Michael","given":"Michael","family":"Durben","role":"aut"},{"role":"aut","family":"Heß","given":"Jochen","display":"Heß, Jochen"},{"given":"Peter","display":"Angel, Peter","role":"aut","family":"Angel"}],"note":["Gesehen am 12.01.2022"],"name":{"displayForm":["Julia S. Leibold, Astrid Riehl, Jan Hettinger, Michael Durben, Jochen Hess and Peter Angel"]},"language":["eng"]} | ||
| SRT | |a LEIBOLDJULKERATINOCY1620 | ||