Protection of the chronic hypoxic immature rat heart during global ischemia
The benefit of cardioplegic cardiac arrest for the protection of immature myocardium is controversial. We therefore investigated the efficacy of (1) topical hypothermia alone, (2) slow cooling by coronary perfusion hypothermia, and (3) cardioplegic cardiac arrest for the protection of isolated immat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 1995
|
| In: |
The annals of thoracic surgery
Year: 1995, Volume: 59, Issue: 3, Pages: 699-706 |
| ISSN: | 1552-6259 |
| DOI: | 10.1016/0003-4975(94)01015-3 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0003-4975(94)01015-3 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/0003497594010153 
|
| Author Notes: | Matthias Karck, Gerhard Ziemer, Max Zoeller, Steffen Schulte, Klaus-D. Juergens, Herwig Weisser, Axel Haverich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1785859471 | ||
| 003 | DE-627 | ||
| 005 | 20220820104657.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220112s1995 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/0003-4975(94)01015-3 |2 doi | |
| 035 | |a (DE-627)1785859471 | ||
| 035 | |a (DE-599)KXP1785859471 | ||
| 035 | |a (OCoLC)1341436923 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Karck, Matthias |d 1961- |e VerfasserIn |0 (DE-588)130833525 |0 (DE-627)505909340 |0 (DE-576)298366169 |4 aut | |
| 245 | 1 | 0 | |a Protection of the chronic hypoxic immature rat heart during global ischemia |c Matthias Karck, Gerhard Ziemer, Max Zoeller, Steffen Schulte, Klaus-D. Juergens, Herwig Weisser, Axel Haverich |
| 246 | 1 | |i Vom Autor zitiert als |a Myocardial protection in chronic hypoxic immature rat hearts during global ischemia | |
| 264 | 1 | |c March 1995 | |
| 264 | 4 | |c 20 July 2000 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.01.2022 | ||
| 520 | |a The benefit of cardioplegic cardiac arrest for the protection of immature myocardium is controversial. We therefore investigated the efficacy of (1) topical hypothermia alone, (2) slow cooling by coronary perfusion hypothermia, and (3) cardioplegic cardiac arrest for the protection of isolated immature rat hearts (28 days) during 8 hours of global ischemia at 10°C. The study was conducted in hearts from rats that were kept hypoxemic by lifelong exposure to simulated high altitude. Left ventricular function, endothelial function, the metabolic status, and the extent of myocardial injury were all assessed. Topical hypothermia provided superior protection in hypoxic hearts, with recovery of the maximum developed left ventricular pressure by 70.6% ± 18.0% (mean ± standard deviation) of its preischemic value (p < 0.01 versus slow cooling and versus cardioplegic protection). The same pattern of recovery was observed among control hearts. The degree of recovery of endothelial function after sole topical hypothermia measured 54% ± 36% in hypoxic hearts and 62% ± 37% in control hearts, but was not recordable in any of the other groups. Creatine kinase leakage and the myocardial high-energy content did not differ significantly among any of the groups. Rapid cooling by topical hypothermia alone provides superior protection in chronic hypoxic, immature rat hearts versus the protection conferred by slow cooling. St. Thomas' Hospital cardioplegic solution II does not afford additional protection. Endothelial injury caused by cold asanguineous perfusates, including cardioplegia, interferes with the recovery of vascular function, which, in turn, may limit mechanical function. | ||
| 700 | 1 | |a Ziemer, Gerhard |e VerfasserIn |0 (DE-588)140083057 |0 (DE-627)61601631X |0 (DE-576)314497021 |4 aut | |
| 700 | 1 | |a Zöller, Max |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schulte, Steffen |d 1967- |e VerfasserIn |0 (DE-588)115385703 |0 (DE-627)691276986 |0 (DE-576)289851114 |4 aut | |
| 700 | 1 | |a Jürgens, Klaus Dieter |d 1947- |e VerfasserIn |0 (DE-588)133441172 |0 (DE-627)545836905 |0 (DE-576)299850633 |4 aut | |
| 700 | 1 | |a Weisser, Herwig |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haverich, Axel |d 1953- |e VerfasserIn |0 (DE-588)130344761 |0 (DE-627)498966836 |0 (DE-576)172337925 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The annals of thoracic surgery |d Amsterdam [u.a.] : Elsevier Science, 1965 |g 59(1995), 3, Seite 699-706 |h Online-Ressource |w (DE-627)306653915 |w (DE-600)1499869-5 |w (DE-576)109633814 |x 1552-6259 |7 nnas |a Protection of the chronic hypoxic immature rat heart during global ischemia |
| 773 | 1 | 8 | |g volume:59 |g year:1995 |g number:3 |g pages:699-706 |g extent:8 |a Protection of the chronic hypoxic immature rat heart during global ischemia |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0003-4975(94)01015-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/0003497594010153 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220112 | ||
| 993 | |a Article | ||
| 994 | |a 1995 | ||
| 998 | |g 130833525 |a Karck, Matthias |m 130833525:Karck, Matthias |p 1 |x j | ||
| 999 | |a KXP-PPN1785859471 |e 4034181818 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1785859471","physDesc":[{"extent":"8 S."}],"origin":[{"dateIssuedDisp":"March 1995","dateIssuedKey":"1995"}],"person":[{"display":"Karck, Matthias","family":"Karck","role":"aut","given":"Matthias"},{"display":"Ziemer, Gerhard","family":"Ziemer","given":"Gerhard","role":"aut"},{"display":"Zöller, Max","family":"Zöller","given":"Max","role":"aut"},{"role":"aut","given":"Steffen","family":"Schulte","display":"Schulte, Steffen"},{"display":"Jürgens, Klaus Dieter","family":"Jürgens","given":"Klaus Dieter","role":"aut"},{"given":"Herwig","role":"aut","family":"Weisser","display":"Weisser, Herwig"},{"display":"Haverich, Axel","family":"Haverich","role":"aut","given":"Axel"}],"relHost":[{"id":{"eki":["306653915"],"issn":["1552-6259"],"zdb":["1499869-5"]},"part":{"extent":"8","text":"59(1995), 3, Seite 699-706","issue":"3","pages":"699-706","volume":"59","year":"1995"},"corporate":[{"display":"Society of Thoracic Surgeons","role":"isb"},{"role":"isb","display":"Southern Thoracic Surgical Association"}],"pubHistory":["1.1965 -"],"disp":"Protection of the chronic hypoxic immature rat heart during global ischemiaThe annals of thoracic surgery","physDesc":[{"extent":"Online-Ressource"}],"recId":"306653915","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 04.09.2018"],"title":[{"title_sort":"annals of thoracic surgery","title":"The annals of thoracic surgery","subtitle":"official journal of the Society of Thoracic Surgeons and the Southern Thoracic Surgical Association"}],"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1965","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1965-"}]}],"title":[{"title_sort":"Protection of the chronic hypoxic immature rat heart during global ischemia","title":"Protection of the chronic hypoxic immature rat heart during global ischemia"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 12.01.2022"],"name":{"displayForm":["Matthias Karck, Gerhard Ziemer, Max Zoeller, Steffen Schulte, Klaus-D. Juergens, Herwig Weisser, Axel Haverich"]},"titleAlt":[{"title":"Myocardial protection in chronic hypoxic immature rat hearts during global ischemia"}],"id":{"doi":["10.1016/0003-4975(94)01015-3"],"eki":["1785859471"]}} | ||
| SRT | |a KARCKMATTHPROTECTION1995 | ||