The FBMD-1 stroma cell line secretes a unique moiety which can increase retroviral transduction of lineage-committed and primitive human peripheral blood progenitor cells
Peripheral blood progenitor cells are a prime target for gene therapy approaches. As recent data point to the relevance of soluble stroma factors for the efficient transduction of progenitor cells, we tested the stroma-conditioned medium (SCM) of the two cell lines FBMD-1 and L88/5 as well as desulf...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 August 2001
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| In: |
Cancer gene therapy
Year: 2001, Jahrgang: 8, Heft: 6, Pages: 440-449 |
| ISSN: | 1476-5500 |
| DOI: | 10.1038/sj.cgt.7700324 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.cgt.7700324 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/7700324 
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| Verfasserangaben: | Eike C. Buss, Bernd Schiedlmeier, Anthony D. Ho, W. Jens Zeller, and Stefan Fruehauf |
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| 520 | |a Peripheral blood progenitor cells are a prime target for gene therapy approaches. As recent data point to the relevance of soluble stroma factors for the efficient transduction of progenitor cells, we tested the stroma-conditioned medium (SCM) of the two cell lines FBMD-1 and L88/5 as well as desulfated and O-sulfated heparin (HS dS and HS OS) for their effect on transduction of peripheral blood progenitor cells. We transduced CD34 + cells of nine tumor patients with the retroviral SF-MDR vector containing the human multidrug resistance 1 ( MDR 1) gene under serum-free conditions on the fibronectin fragment CH-296 with or without SCM. | ||
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