Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping
A venous thromboembolism (VTE) with the subsequent risk of pulmonary embolism is a major concern in the treatment of patients with multiple myeloma with thalidomide. The susceptibility to developing a VTE in response to thalidomide therapy is likely to be influenced by both genetic and environmental...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[December 15 2008 ]
|
| In: |
Blood
Year: 2008, Jahrgang: 112, Heft: 13, Pages: 4924-4934 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2008-02-140434 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2008-02-140434
|
| Verfasserangaben: | David C. Johnson, Sophie Corthals, Christine Ramos, Antje Hoering, Kim Cocks, Nicholas J. Dickens, Jeff Haessler, Harmut Goldschmidt, J. Anthony Child, Sue E. Bell, Graham Jackson, Dalsu Baris, S. Vincent Rajkumar, Faith E. Davies, Brian G. M. Durie, John Crowley, Pieter Sonneveld, Brian Van Ness, and Gareth J. Morgan |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1786116995 | ||
| 003 | DE-627 | ||
| 005 | 20230428030359.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220114s2008 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood-2008-02-140434 |2 doi | |
| 035 | |a (DE-627)1786116995 | ||
| 035 | |a (DE-599)KXP1786116995 | ||
| 035 | |a (OCoLC)1341437115 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Johnson, David C. |e VerfasserIn |0 (DE-588)120963029X |0 (DE-627)169731449X |4 aut | |
| 245 | 1 | 0 | |a Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping |c David C. Johnson, Sophie Corthals, Christine Ramos, Antje Hoering, Kim Cocks, Nicholas J. Dickens, Jeff Haessler, Harmut Goldschmidt, J. Anthony Child, Sue E. Bell, Graham Jackson, Dalsu Baris, S. Vincent Rajkumar, Faith E. Davies, Brian G. M. Durie, John Crowley, Pieter Sonneveld, Brian Van Ness, and Gareth J. Morgan |
| 264 | 1 | |c [December 15 2008 ] | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Preepublished online as Blood first edition paper, September 19, 2008 | ||
| 500 | |a Gesehen am 14.01.2022 | ||
| 520 | |a A venous thromboembolism (VTE) with the subsequent risk of pulmonary embolism is a major concern in the treatment of patients with multiple myeloma with thalidomide. The susceptibility to developing a VTE in response to thalidomide therapy is likely to be influenced by both genetic and environmental factors. To test genetic variation associated with treatment related VTE in patient peripheral blood DNA, we used a custom-built molecular inversion probe (MIP)-based single nucleotide polymorphism (SNP) chip containing 3404 SNPs. SNPs on the chip were selected in “functional regions” within 964 genes spanning 67 molecular pathways thought to be involved in the pathogenesis, treatment response, and side effects associated with myeloma therapy. Patients and controls were taken from 3 large clinical trials: Medical Research Council (MRC) Myeloma IX, Hovon-50, and Eastern Cooperative Oncology Group (ECOG) EA100, which compared conventional treatments with thalidomide in patients with myeloma. Our analysis showed that the set of SNPs associated with thalidomide-related VTE were enriched in genes and pathways important in drug transport/metabolism, DNA repair, and cytokine balance. The effects of the SNPs associated with thalidomide-related VTE may be functional at the level of the tumor cell, the tumor-related microenvironment, and the endothelium. The clinical trials described in this paper have been registered as follows: MRC Myeloma IX: ISRCTN68454111; Hovon-50: NCT00028886; and ECOG EA100: NCT00033332. | ||
| 700 | 1 | |a Corthals, Sophie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ramos, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoering, Antje |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cocks, Kim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dickens, Nicholas J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haessler, Jeff |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Child, J. Anthony |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bell, Sue E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jackson, Graham |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baris, Dalsu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rajkumar, S. Vincent |e VerfasserIn |4 aut | |
| 700 | 1 | |a Davies, Faith E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Durie, Brian G. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Crowley, John |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sonneveld, Pieter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Van Ness, Brian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Morgan, Gareth J. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 112(2008), 13, Seite 4924-4934 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping |
| 773 | 1 | 8 | |g volume:112 |g year:2008 |g number:13 |g pages:4924-4934 |g extent:11 |a Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping |
| 856 | 4 | 0 | |u https://doi.org/10.1182/blood-2008-02-140434 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220114 | ||
| 993 | |a Article | ||
| 994 | |a 2008 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 8 | ||
| 999 | |a KXP-PPN1786116995 |e 4035752487 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1786116995"],"doi":["10.1182/blood-2008-02-140434"]},"title":[{"title_sort":"Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping","title":"Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping"}],"recId":"1786116995","note":["Preepublished online as Blood first edition paper, September 19, 2008","Gesehen am 14.01.2022"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"[December 15 2008 ]","dateIssuedKey":"2008"}],"physDesc":[{"noteIll":"Illustrationen","extent":"11 S."}],"person":[{"given":"David C.","display":"Johnson, David C.","role":"aut","roleDisplay":"VerfasserIn","family":"Johnson"},{"given":"Sophie","display":"Corthals, Sophie","role":"aut","family":"Corthals","roleDisplay":"VerfasserIn"},{"family":"Ramos","roleDisplay":"VerfasserIn","given":"Christine","role":"aut","display":"Ramos, Christine"},{"family":"Hoering","roleDisplay":"VerfasserIn","role":"aut","display":"Hoering, Antje","given":"Antje"},{"role":"aut","display":"Cocks, Kim","given":"Kim","roleDisplay":"VerfasserIn","family":"Cocks"},{"given":"Nicholas J.","role":"aut","display":"Dickens, Nicholas J.","family":"Dickens","roleDisplay":"VerfasserIn"},{"given":"Jeff","display":"Haessler, Jeff","role":"aut","family":"Haessler","roleDisplay":"VerfasserIn"},{"family":"Goldschmidt","roleDisplay":"VerfasserIn","given":"Hartmut","role":"aut","display":"Goldschmidt, Hartmut"},{"display":"Child, J. Anthony","role":"aut","given":"J. Anthony","family":"Child","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Bell","role":"aut","display":"Bell, Sue E.","given":"Sue E."},{"display":"Jackson, Graham","role":"aut","given":"Graham","roleDisplay":"VerfasserIn","family":"Jackson"},{"given":"Dalsu","display":"Baris, Dalsu","role":"aut","family":"Baris","roleDisplay":"VerfasserIn"},{"display":"Rajkumar, S. Vincent","role":"aut","given":"S. Vincent","family":"Rajkumar","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Davies","display":"Davies, Faith E.","role":"aut","given":"Faith E."},{"given":"Brian G. M.","role":"aut","display":"Durie, Brian G. M.","family":"Durie","roleDisplay":"VerfasserIn"},{"given":"John","role":"aut","display":"Crowley, John","family":"Crowley","roleDisplay":"VerfasserIn"},{"given":"Pieter","role":"aut","display":"Sonneveld, Pieter","family":"Sonneveld","roleDisplay":"VerfasserIn"},{"given":"Brian","role":"aut","display":"Van Ness, Brian","family":"Van Ness","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Morgan, Gareth J.","given":"Gareth J.","roleDisplay":"VerfasserIn","family":"Morgan"}],"name":{"displayForm":["David C. Johnson, Sophie Corthals, Christine Ramos, Antje Hoering, Kim Cocks, Nicholas J. Dickens, Jeff Haessler, Harmut Goldschmidt, J. Anthony Child, Sue E. Bell, Graham Jackson, Dalsu Baris, S. Vincent Rajkumar, Faith E. Davies, Brian G. M. Durie, John Crowley, Pieter Sonneveld, Brian Van Ness, and Gareth J. Morgan"]},"relHost":[{"recId":"266886647","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"American Society of Hematology","role":"isb"}],"titleAlt":[{"title":"Blood online"}],"pubHistory":["1.1946 -"],"disp":"Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotypingBlood","note":["Gesehen am 21.04.2023"],"id":{"zdb":["1468538-3"],"eki":["266886647"],"issn":["1528-0020"]},"title":[{"subtitle":"journal of the American Society of Hematology","title":"Blood","title_sort":"Blood"}],"language":["eng"],"origin":[{"dateIssuedDisp":"1946-","publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif.","dateIssuedKey":"1946","publisher":"American Society of Hematology ; Saunders ; HighWire Press"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"text":"112(2008), 13, Seite 4924-4934","issue":"13","volume":"112","year":"2008","extent":"11","pages":"4924-4934"},"physDesc":[{"extent":"Online-Ressource"}]}]} | ||
| SRT | |a JOHNSONDAVGENETICASS1520 | ||