Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in children and are associated with lifelong clinical morbidity. Relative to their high-grade adult counterparts or other malignant childhood brain tumors, there is a paucity of authenticated preclinical models for these pLGGs and a...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 June 2021
|
| In: |
Neuro-Oncology
Year: 2021, Jahrgang: 23, Heft: 10, Pages: 1634-1646 |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/noab138 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/neuonc/noab138
|
| Verfasserangaben: | Till Milde, Fausto J. Rodriguez, Jill S. Barnholtz-Sloan, Nirav Patil, Charles G. Eberhart, and David H. Gutmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1786202239 | ||
| 003 | DE-627 | ||
| 005 | 20220820105758.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220115s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/neuonc/noab138 |2 doi | |
| 035 | |a (DE-627)1786202239 | ||
| 035 | |a (DE-599)KXP1786202239 | ||
| 035 | |a (OCoLC)1341436812 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Milde, Till |d 1973- |e VerfasserIn |0 (DE-588)1038311837 |0 (DE-627)75711234X |0 (DE-576)39229334X |4 aut | |
| 245 | 1 | 0 | |a Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas |c Till Milde, Fausto J. Rodriguez, Jill S. Barnholtz-Sloan, Nirav Patil, Charles G. Eberhart, and David H. Gutmann |
| 264 | 1 | |c 16 June 2021 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.01.2022 | ||
| 520 | |a Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in children and are associated with lifelong clinical morbidity. Relative to their high-grade adult counterparts or other malignant childhood brain tumors, there is a paucity of authenticated preclinical models for these pLGGs and an incomplete understanding of their molecular and cellular pathogenesis. While large-scale genomic profiling efforts have identified the majority of pathogenic driver mutations, which converge on the MAPK/ERK signaling pathway, it is now appreciated that these events may not be sufficient by themselves for gliomagenesis and clinical progression. In light of the recent World Health Organization reclassification of pLGGs, and pilocytic astrocytoma (PA), in particular, we review our current understanding of these pediatric brain tumors, provide a conceptual framework for future mechanistic studies, and outline the challenges and pressing needs for the pLGG clinical and research communities. | ||
| 700 | 1 | |a Rodriguez, Fausto J |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barnholtz-Sloan, Jill S |e VerfasserIn |4 aut | |
| 700 | 1 | |a Patil, Nirav |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eberhart, Charles G |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gutmann, David H |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuro-Oncology |d Oxford : Oxford Univ. Press, 1999 |g 23(2021), 10 vom: Okt., Seite 1634-1646 |h Online-Ressource |w (DE-627)357167341 |w (DE-600)2094060-9 |w (DE-576)318041839 |x 1523-5866 |7 nnas |a Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas |
| 773 | 1 | 8 | |g volume:23 |g year:2021 |g number:10 |g month:10 |g pages:1634-1646 |g extent:13 |a Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas |
| 856 | 4 | 0 | |u https://doi.org/10.1093/neuonc/noab138 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220115 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1038311837 |a Milde, Till |m 1038311837:Milde, Till |d 910000 |d 910500 |d 50000 |e 910000PM1038311837 |e 910500PM1038311837 |e 50000PM1038311837 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1786202239 |e 403622753X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"recId":"357167341","disp":"Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomasNeuro-Oncology","id":{"zdb":["2094060-9"],"issn":["1523-5866"],"eki":["357167341"]},"origin":[{"publisherPlace":"Oxford ; Durham, NC","dateIssuedDisp":"1999-","publisher":"Oxford Univ. Press ; Duke University Medical Center","dateIssuedKey":"1999"}],"part":{"volume":"23","pages":"1634-1646","extent":"13","text":"23(2021), 10 vom: Okt., Seite 1634-1646","year":"2021","issue":"10"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 21.07.23"],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1999 -"],"language":["eng"],"title":[{"subtitle":"official journal of the World Federation of Neuro-Oncology","title":"Neuro-Oncology","title_sort":"Neuro-Oncology"}]}],"note":["Gesehen am 15.01.2022"],"recId":"1786202239","name":{"displayForm":["Till Milde, Fausto J. Rodriguez, Jill S. Barnholtz-Sloan, Nirav Patil, Charles G. Eberhart, and David H. Gutmann"]},"origin":[{"dateIssuedDisp":"16 June 2021","dateIssuedKey":"2021"}],"id":{"doi":["10.1093/neuonc/noab138"],"eki":["1786202239"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"13 S."}],"language":["eng"],"title":[{"title":"Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas","title_sort":"Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas"}],"person":[{"display":"Milde, Till","family":"Milde","role":"aut","given":"Till"},{"family":"Rodriguez","given":"Fausto J","role":"aut","display":"Rodriguez, Fausto J"},{"display":"Barnholtz-Sloan, Jill S","family":"Barnholtz-Sloan","role":"aut","given":"Jill S"},{"given":"Nirav","role":"aut","family":"Patil","display":"Patil, Nirav"},{"display":"Eberhart, Charles G","role":"aut","given":"Charles G","family":"Eberhart"},{"display":"Gutmann, David H","role":"aut","given":"David H","family":"Gutmann"}]} | ||
| SRT | |a MILDETILLRREIMAGININ1620 | ||