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C3 and C4 complement levels in AQP4-IgG-positive NMOSD and in MOGAD

While complement-dependent cytotoxicity (CDC) is a known effector mechanism in aquaporin-4-immunoglobulin (Ig)G-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD), the role of CDC in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is less clear. We determined...

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Hauptverfasser: Pache, Florence (VerfasserIn) , Ringelstein, Marius (VerfasserIn) , Aktas, Orhan (VerfasserIn) , Kleiter, Ingo (VerfasserIn) , Jarius, Sven (VerfasserIn) , Siebert, Nadja (VerfasserIn) , Bellmann-Strobl, Judith (VerfasserIn) , Paul, Friedemann (VerfasserIn) , Ruprecht, Klemens (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 August 2021
In: Journal of neuroimmunology
Year: 2021, Jahrgang: 360, Pages: 1-5
ISSN:1872-8421
DOI:10.1016/j.jneuroim.2021.577699
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2021.577699
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572821002265
Volltext
Verfasserangaben:Florence Pache, Marius Ringelstein, Orhan Aktas, Ingo Kleiter, Sven Jarius, Nadja Siebert, Judith Bellmann-Strobl, Friedemann Paul, Klemens Ruprecht

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520 |a While complement-dependent cytotoxicity (CDC) is a known effector mechanism in aquaporin-4-immunoglobulin (Ig)G-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD), the role of CDC in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is less clear. We determined complement C3 and C4 plasma concentrations in patients with clinically stable AQP4-IgG+ NMOSD (n = 16), MOGAD (n = 15), early multiple sclerosis (MS, n = 19) and in healthy controls (HC, n = 18). C4 was lower in AQP4-IgG+ NMOSD than in MOGAD, MS and HC (p < 0.05, pairwise comparisons). C3 was lower in AQP4-IgG+ NMOSD than in MS (p = 0.034). These findings suggest subtle complement consumption in clinically stable AQP4-IgG+ NMOSD, but not in MOGAD. 
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