C3 and C4 complement levels in AQP4-IgG-positive NMOSD and in MOGAD
While complement-dependent cytotoxicity (CDC) is a known effector mechanism in aquaporin-4-immunoglobulin (Ig)G-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD), the role of CDC in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is less clear. We determined...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 August 2021
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| In: |
Journal of neuroimmunology
Year: 2021, Jahrgang: 360, Pages: 1-5 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2021.577699 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2021.577699 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572821002265 
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| Verfasserangaben: | Florence Pache, Marius Ringelstein, Orhan Aktas, Ingo Kleiter, Sven Jarius, Nadja Siebert, Judith Bellmann-Strobl, Friedemann Paul, Klemens Ruprecht |
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| 520 | |a While complement-dependent cytotoxicity (CDC) is a known effector mechanism in aquaporin-4-immunoglobulin (Ig)G-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD), the role of CDC in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is less clear. We determined complement C3 and C4 plasma concentrations in patients with clinically stable AQP4-IgG+ NMOSD (n = 16), MOGAD (n = 15), early multiple sclerosis (MS, n = 19) and in healthy controls (HC, n = 18). C4 was lower in AQP4-IgG+ NMOSD than in MOGAD, MS and HC (p < 0.05, pairwise comparisons). C3 was lower in AQP4-IgG+ NMOSD than in MS (p = 0.034). These findings suggest subtle complement consumption in clinically stable AQP4-IgG+ NMOSD, but not in MOGAD. | ||
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| 650 | 4 | |a C3 | |
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| 650 | 4 | |a Complement | |
| 650 | 4 | |a Myelin oligodendrocyte glycoprotein | |
| 650 | 4 | |a Neuromyelitis optica spectrum disorder | |
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