Queuine links translational control in eukaryotes to a micronutrient from bacteria
In eukaryotes, the wobble position of tRNA with a GUN anticodon is modified to the 7-deaza-guanosine derivative queuosine (Q34), but the original source of Q is bacterial, since Q is synthesized by eubacteria and salvaged by eukaryotes for incorporation into tRNA. Q34 modification stimulates Dnmt2/P...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 April 2019
|
| In: |
Nucleic acids research
Year: 2019, Jahrgang: 47, Heft: 7, Pages: 3711-3727 |
| ISSN: | 1362-4962 |
| DOI: | 10.1093/nar/gkz063 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/gkz063
|
| Verfasserangaben: | Martin Müller, Carine Legrand, Francesca Tuorto, Vincent P. Kelly, Yaser Atlasi, Frank Lyko and Ann E. Ehrenhofer-Murray |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1786288419 | ||
| 003 | DE-627 | ||
| 005 | 20220820110317.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220117s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/nar/gkz063 |2 doi | |
| 035 | |a (DE-627)1786288419 | ||
| 035 | |a (DE-599)KXP1786288419 | ||
| 035 | |a (OCoLC)1341436964 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Müller, Martin |e VerfasserIn |4 aut | |
| 245 | 1 | 0 | |a Queuine links translational control in eukaryotes to a micronutrient from bacteria |c Martin Müller, Carine Legrand, Francesca Tuorto, Vincent P. Kelly, Yaser Atlasi, Frank Lyko and Ann E. Ehrenhofer-Murray |
| 264 | 1 | |c 23 April 2019 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht am 1. Februar 2019 | ||
| 500 | |a Gesehen am 17.01.2022 | ||
| 520 | |a In eukaryotes, the wobble position of tRNA with a GUN anticodon is modified to the 7-deaza-guanosine derivative queuosine (Q34), but the original source of Q is bacterial, since Q is synthesized by eubacteria and salvaged by eukaryotes for incorporation into tRNA. Q34 modification stimulates Dnmt2/Pmt1-dependent C38 methylation (m5C38) in the tRNAAsp anticodon loop in Schizosaccharomyces pombe. Here, we show by ribosome profiling in S. pombe that Q modification enhances the translational speed of the C-ending codons for aspartate (GAC) and histidine (CAC) and reduces that of U-ending codons for asparagine (AAU) and tyrosine (UAU), thus equilibrating the genome-wide translation of synonymous Q codons. Furthermore, Q prevents translation errors by suppressing second-position misreading of the glycine codon GGC, but not of wobble misreading. The absence of Q causes reduced translation of mRNAs involved in mitochondrial functions, and accordingly, lack of Q modification causes a mitochondrial defect in S. pombe. We also show that Q-dependent stimulation of Dnmt2 is conserved in mice. Our findings reveal a direct mechanism for the regulation of translational speed and fidelity in eukaryotes by a nutrient originating from bacteria. | ||
| 700 | 1 | |a Legrand, Carine |d 1978- |e VerfasserIn |0 (DE-588)1091098808 |0 (DE-627)852266650 |0 (DE-576)46125705X |4 aut | |
| 700 | 1 | |a Tuorto, Francesca |e VerfasserIn |0 (DE-588)1122208154 |0 (DE-627)875231187 |0 (DE-576)481189092 |4 aut | |
| 700 | 1 | |a Kelly, Vincent P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Atlasi, Yaser |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lyko, Frank |e VerfasserIn |0 (DE-588)1106120361 |0 (DE-627)862900018 |0 (DE-576)473860597 |4 aut | |
| 700 | 1 | |a Ehrenhofer-Murray, Ann Elizabeth |e VerfasserIn |0 (DE-588)1042644055 |0 (DE-627)769163033 |0 (DE-576)394085507 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nucleic acids research |d Oxford : Oxford Univ. Press, 1974 |g 47(2019), 7, Seite 3711-3727 |h Online-Ressource |w (DE-627)26813250X |w (DE-600)1472175-2 |w (DE-576)07760878X |x 1362-4962 |7 nnas |a Queuine links translational control in eukaryotes to a micronutrient from bacteria |
| 773 | 1 | 8 | |g volume:47 |g year:2019 |g number:7 |g pages:3711-3727 |g extent:17 |a Queuine links translational control in eukaryotes to a micronutrient from bacteria |
| 856 | 4 | 0 | |u https://doi.org/10.1093/nar/gkz063 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220117 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1106120361 |a Lyko, Frank |m 1106120361:Lyko, Frank |d 50000 |e 50000PL1106120361 |k 0/50000/ |p 6 | ||
| 998 | |g 1122208154 |a Tuorto, Francesca |m 1122208154:Tuorto, Francesca |p 3 | ||
| 998 | |g 1091098808 |a Legrand, Carine |m 1091098808:Legrand, Carine |p 2 | ||
| 999 | |a KXP-PPN1786288419 |e 4036815288 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Veröffentlicht am 1. Februar 2019","Gesehen am 17.01.2022"],"name":{"displayForm":["Martin Müller, Carine Legrand, Francesca Tuorto, Vincent P. Kelly, Yaser Atlasi, Frank Lyko and Ann E. Ehrenhofer-Murray"]},"recId":"1786288419","origin":[{"dateIssuedDisp":"23 April 2019","dateIssuedKey":"2019"}],"language":["eng"],"person":[{"given":"Martin","family":"Müller","role":"aut","display":"Müller, Martin"},{"display":"Legrand, Carine","role":"aut","family":"Legrand","given":"Carine"},{"role":"aut","display":"Tuorto, Francesca","given":"Francesca","family":"Tuorto"},{"given":"Vincent P.","family":"Kelly","role":"aut","display":"Kelly, Vincent P."},{"role":"aut","display":"Atlasi, Yaser","given":"Yaser","family":"Atlasi"},{"given":"Frank","family":"Lyko","role":"aut","display":"Lyko, Frank"},{"role":"aut","display":"Ehrenhofer-Murray, Ann Elizabeth","given":"Ann Elizabeth","family":"Ehrenhofer-Murray"}],"title":[{"title_sort":"Queuine links translational control in eukaryotes to a micronutrient from bacteria","title":"Queuine links translational control in eukaryotes to a micronutrient from bacteria"}],"relHost":[{"disp":"Queuine links translational control in eukaryotes to a micronutrient from bacteriaNucleic acids research","note":["Gesehen am 15.09.2025","Ungezählte Beil.: Database issue; Web server issue"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Nucleic acids research","title":"Nucleic acids research"}],"recId":"26813250X","titleAlt":[{"title":"NAR online"},{"title":"NAR"},{"title":"Database issue"},{"title":"Web server issue"}],"origin":[{"publisherPlace":"Oxford","dateIssuedKey":"1974","publisher":"Oxford Univ. Press","dateIssuedDisp":"1974-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["26813250X"],"issn":["1362-4962"],"zdb":["1472175-2"]},"pubHistory":["1.1974 -"],"part":{"volume":"47","year":"2019","extent":"17","issue":"7","pages":"3711-3727","text":"47(2019), 7, Seite 3711-3727"}}],"physDesc":[{"extent":"17 S."}],"id":{"eki":["1786288419"],"doi":["10.1093/nar/gkz063"]},"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a MUELLERMARQUEUINELIN2320 | ||