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Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation

Patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) have a poor prognosis with conventional chemotherapy. In the present study, we retrospectively analyzed the outcome of patients with BPDCN who underwent allogeneic stem cell transplantation (allo-SCT) or autologous stem cell transpla...

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Main Authors: Roos-Weil, Damien (Author) , Dietrich, Sascha (Author) , Boumendil, Ariane (Author) , Polge, Emmanuelle (Author) , Bron, Dominique (Author) , Carreras, Enric (Author) , Iriondo Atienza, Arturo (Author) , Arcese, William (Author) , Beelen, Dietrich W. (Author) , Cornelissen, Jan J. (Author) , Kröger, Nicolaus (Author) , Milone, Giuseppe (Author) , Rossi, Giuseppe (Author) , Jardin, Fabrice (Author) , Peters, Christina (Author) , Rocha, Vanderson (Author) , Sureda, Anna (Author) , Mohty, Mohamad (Author) , Dreger, Peter (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Blood
Year: 2013, Volume: 121, Issue: 3, Pages: 440-446
ISSN:1528-0020
DOI:10.1182/blood-2012-08-448613
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2012-08-448613
Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/blood/article/121/3/440/30983/Stem-cell-transplantation-can-provide-durable
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Author Notes:Damien Roos-Weil, Sascha Dietrich, Ariane Boumendil, Emmanuelle Polge, Dominique Bron, Enric Carreras, Arturo Iriondo Atienza, William Arcese, Dietrich W. Beelen, Jan J. Cornelissen, Nicolaus Kröger, Giuseppe Milone, Giuseppe Rossi, Fabrice Jardin, Christina Peters, Vanderson Rocha, Anna Sureda, Mohamad Mohty, and Peter Dreger, on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties
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Summary:Patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) have a poor prognosis with conventional chemotherapy. In the present study, we retrospectively analyzed the outcome of patients with BPDCN who underwent allogeneic stem cell transplantation (allo-SCT) or autologous stem cell transplantation (auto-SCT). A total of 39 patients (allo-SCT, n = 34; auto-SCT, n = 5) were identified in the European Group for Blood and Marrow Transplantation registry. The 34 allo-SCT patients had a median age of 41 years (range, 10-70) and received transplantations from sibling (n = 11) or unrelated donors (n = 23) between 2003 and 2009. MAC was used in 74% of patients. Nineteen allo-SCT patients (56%) received transplantations in first complete remission. The 3-year cumulative incidence of relapse, disease-free survival, and overall survival was 32%, 33%, and 41%, respectively. By univariate comparison, being in first remission at allo-SCT favorably influenced survival, whereas age, donor source, and chronic GVHD had no significant impact. We conclude that high-dose therapy followed by allo-SCT from related or unrelated donors can provide durable remission even in elderly patients with BPDCN. However, it remains to be shown if graft-versus-malignancy effects can contribute significantly to BPDCN control after allo-SCT.
Item Description:Prepublished online November 30, 2012
Gesehen am 19.01.2022
Physical Description:Online Resource
ISSN:1528-0020
DOI:10.1182/blood-2012-08-448613

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