Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practice
We investigated first-line (1L) treatment patterns and predictors of taxane use to better understand the evolving metastatic triple-negative breast cancer (mTNBC) treatment landscape. This retrospective analysis of the Truven Health MarketScan® (Somers, NY, USA) Database included women with mTNBC wh...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 July 2021
|
| In: |
Current oncology
Year: 2021, Jahrgang: 28, Heft: 4, Pages: 2741-2752 |
| ISSN: | 1718-7729 |
| DOI: | 10.3390/curroncol28040239 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/curroncol28040239 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1718-7729/28/4/239 
|
| Verfasserangaben: | Joyce O’Shaughnessy, Leisha A. Emens, Stephen Y. Chui, Wei Wang, Kenneth Russell, Shih-Wen Lin, Carlos Flores Avile, Patricia Luhn and Andreas Schneeweiss |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1786602598 | ||
| 003 | DE-627 | ||
| 005 | 20220820111757.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220120s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/curroncol28040239 |2 doi | |
| 035 | |a (DE-627)1786602598 | ||
| 035 | |a (DE-599)KXP1786602598 | ||
| 035 | |a (OCoLC)1341438905 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a O’Shaughnessy, Joyce |e VerfasserIn |0 (DE-588)1249961696 |0 (DE-627)1786603772 |4 aut | |
| 245 | 1 | 0 | |a Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practice |c Joyce O’Shaughnessy, Leisha A. Emens, Stephen Y. Chui, Wei Wang, Kenneth Russell, Shih-Wen Lin, Carlos Flores Avile, Patricia Luhn and Andreas Schneeweiss |
| 264 | 1 | |c 17 July 2021 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.01.2022 | ||
| 520 | |a We investigated first-line (1L) treatment patterns and predictors of taxane use to better understand the evolving metastatic triple-negative breast cancer (mTNBC) treatment landscape. This retrospective analysis of the Truven Health MarketScan® (Somers, NY, USA) Database included women with mTNBC who received 1L therapy within six months of diagnosis (January 2005-June 2015). Multivariate logistic regression models identified predictors of taxane use, adjusting for prognostic factors. A total of 2271 women with newly diagnosed mTNBC received 1L treatment during the study period. Half received a 1L taxane (53%), more often in combination than as monotherapy (58% versus 42%), though this varied by specific taxane. Nab-Paclitaxel monotherapy increased substantially after 2010. More recent treatment year (odds ratio, 2.16 (95% CI 1.69-2.76]) and number of metastases (≥3 versus 1: 1.73 (1.25-2.40)) predicted taxane monotherapy versus combination. Having a health maintenance organization versus a preferred provider organization plan predicted less nab-paclitaxel versus paclitaxel (0.32 (0.13-0.80)) or docetaxel (0.30 (0.10-0.89)) use. More recent index year (2011-2015 vs. 2005-2010) was the only predictor favoring nab-paclitaxel versus paclitaxel (2.01 (1.26-3.21)) or docetaxel (3.63 (2.11-6.26)). Taxane-containing regimens remained the most common 1L mTNBC treatments. Paclitaxel and nab-paclitaxel use changed substantially over time, with nab-paclitaxel use associated with insurance coverage. | ||
| 700 | 1 | |a Emens, Leisha A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chui, Stephen Y. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Wei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Russell, Kenneth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lin, Shih-Wen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Flores Avile, Carlos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luhn, Patricia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneeweiss, Andreas |d 1961- |e VerfasserIn |0 (DE-588)109972554 |0 (DE-627)632849630 |0 (DE-576)327251859 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current oncology |d Toronto, Ontario : Multimed, 2005 |g 28(2021), 4, Seite 2741-2752 |h Online-Ressource |w (DE-627)524623112 |w (DE-600)2270777-3 |w (DE-576)347278280 |x 1718-7729 |7 nnas |a Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practice |
| 773 | 1 | 8 | |g volume:28 |g year:2021 |g number:4 |g pages:2741-2752 |g extent:12 |a Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practice |
| 856 | 4 | 0 | |u https://doi.org/10.3390/curroncol28040239 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1718-7729/28/4/239 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220120 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 109972554 |a Schneeweiss, Andreas |m 109972554:Schneeweiss, Andreas |d 910000 |d 910400 |d 50000 |e 910000PS109972554 |e 910400PS109972554 |e 50000PS109972554 |k 0/910000/ |k 1/910000/910400/ |k 0/50000/ |p 9 |y j | ||
| 999 | |a KXP-PPN1786602598 |e 403986784X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"12 S."}],"id":{"doi":["10.3390/curroncol28040239"],"eki":["1786602598"]},"name":{"displayForm":["Joyce O’Shaughnessy, Leisha A. Emens, Stephen Y. Chui, Wei Wang, Kenneth Russell, Shih-Wen Lin, Carlos Flores Avile, Patricia Luhn and Andreas Schneeweiss"]},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"17 July 2021"}],"relHost":[{"title":[{"title_sort":"Current oncology","title":"Current oncology"}],"note":["Gesehen am 21.11.2025","Volltext auch als Teil einer Datenbank verfügbar"],"id":{"zdb":["2270777-3"],"eki":["524623112"],"issn":["1718-7729"]},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"524623112","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["Nachgewiesen 12.2005 -"],"part":{"issue":"4","text":"28(2021), 4, Seite 2741-2752","volume":"28","extent":"12","year":"2021","pages":"2741-2752"},"origin":[{"publisher":"Multimed","dateIssuedDisp":"2005-","dateIssuedKey":"2005","publisherPlace":"Toronto, Ontario"}],"disp":"Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practiceCurrent oncology"}],"recId":"1786602598","title":[{"title_sort":"Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practice","title":"Patterns and predictors of first-line taxane use in patients with metastatic triple-negative breast cancer in US clinical practice"}],"note":["Gesehen am 20.01.2022"],"language":["eng"],"person":[{"display":"O’Shaughnessy, Joyce","family":"O’Shaughnessy","role":"aut","given":"Joyce"},{"given":"Leisha A.","role":"aut","family":"Emens","display":"Emens, Leisha A."},{"given":"Stephen Y.","role":"aut","family":"Chui","display":"Chui, Stephen Y."},{"role":"aut","given":"Wei","display":"Wang, Wei","family":"Wang"},{"role":"aut","given":"Kenneth","display":"Russell, Kenneth","family":"Russell"},{"family":"Lin","display":"Lin, Shih-Wen","given":"Shih-Wen","role":"aut"},{"display":"Flores Avile, Carlos","family":"Flores Avile","role":"aut","given":"Carlos"},{"given":"Patricia","role":"aut","family":"Luhn","display":"Luhn, Patricia"},{"display":"Schneeweiss, Andreas","family":"Schneeweiss","role":"aut","given":"Andreas"}]} | ||
| SRT | |a OSHAUGHNESPATTERNSAN1720 | ||