Right atrium size in the general population

Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A refer...

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Main Authors: Keller, Karsten (Author) , Sinning, Christoph (Author) , Schulz, Andreas (Author) , Jünger, Claus (Author) , Schmitt, Volker H. (Author) , Hahad, Omar (Author) , Zeller, Tanja (Author) , Beutel, Manfred (Author) , Pfeiffer, Norbert (Author) , Strauch, Konstantin (Author) , Blankenberg, Stefan (Author) , Lackner, Karl J. (Author) , Prochaska, Jürgen H. (Author) , Schulz, Eberhard (Author) , Münzel, Thomas (Author) , Wild, Philipp S. (Author)
Format: Article (Journal)
Language:English
Published: 18 November 2021
In: Scientific reports
Year: 2021, Volume: 11, Pages: 1-11
ISSN:2045-2322
DOI:10.1038/s41598-021-01968-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41598-021-01968-y
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41598-021-01968-y
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Author Notes:Karsten Keller, Christoph Sinning, Andreas Schulz, Claus Jünger, Volker H. Schmitt, Omar Hahad, Tanja Zeller, Manfred Beutel, Norbert Pfeiffer, Konstantin Strauch, Stefan Blankenberg, Karl J. Lackner, Jürgen H. Prochaska, Eberhard Schulz, Thomas Münzel & Philipp S. Wild

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520 |a Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th percentile of the reference sample. Results showed sex-specific differences with larger RA dimensions in men that were attenuated by standardization for body-height. RA-volume was 20.2 ml/m in women (5th-95th: 12.7-30.4 ml/m) and 26.1 ml/m in men (5th-95th: 16.0-40.5 ml/m). Multivariable regressions identified body-mass-index (BMI), coronary artery disease (CAD), chronic heart failure (CHF) and atrial fibrillation (AF) as independent key correlates of RA-volume in both sexes. All-cause mortality after median follow-up-period of 10.7 (9.81/11.6) years was higher in individuals who had RA volume/height outside the 95% reference limit (HR 1.70 [95%CI 1.29-2.23], P = 0.00014)). Based on a large community-based sample, we present sex-specific reference-values for RA dimensions normalized for height. RA-volume varies with BMI, CHF, CAD and AF in both sexes. Individuals with RA-volume outside the reference limit had a 1.7-fold higher mortality than those within reference limits. 
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