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Evaluation of the serum-free light chain test in untreated patients with AL amyloidosis

We evaluated the Serum Free Light Chain (FLC) test in a series of 133 untreated patients with systemic AL amyloidosis. The FLC test detected the monoclonal gammopathy in 87% compared with 92% for immunofixation of serum and urine in combination. However, both tests proved complementary. The FLC test...

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Main Authors: Bochtler, Tilmann (Author) , Heiß, Christiane (Author) , Benner, Axel (Author) , Cremer, Friedrich Walter (Author) , Volkmann, Martin (Author) , Ludwig, Jochen (Author) , Dengler, Jolanta (Author) , Ho, Anthony Dick (Author) , Goldschmidt, Hartmut (Author) , Schönland, Stefan (Author)
Other Authors: Hegenbart, Ute (Other)
Format: Article (Journal)
Language:English
Published: [March, 2008]
In: Haematologica, the hematology journal
Year: 2008, Volume: 93, Issue: 3, Pages: 459-462
ISSN:1592-8721
DOI:10.3324/haematol.11687
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3324/haematol.11687
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Author Notes:Tilmann Bochtler, Ute Hegenbart, Christiane Heiss, Axel Benner, Friedrich Cremer, Martin Volkmann, Jochen Ludwig, Jolanta B. Perz, Anthony D. Ho, Hartmut Goldschmidt, and Stefan O. Schonland
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Summary:We evaluated the Serum Free Light Chain (FLC) test in a series of 133 untreated patients with systemic AL amyloidosis. The FLC test detected the monoclonal gammopathy in 87% compared with 92% for immunofixation of serum and urine in combination. However, both tests proved complementary. The FLC test was also a valuable tool in patients with advanced renal failure in spite of uninvolved light chain retention. Higher FLC levels were associated with higher bone marrow plasmocytosis, poorer Karnofsky index and heart involvement, and therefore reflected disease severity.
Item Description:Gesehen am 22.01.2022
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.11687

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