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Input of DNA Microarrays to Identify Novel Mechanisms in Multiple Myeloma Biology and Therapeutic Applications

Multiple myeloma is a B-cell neoplasia characterized by the proliferation of a clone of malignant plasma cells in the bone marrow. We review here the input of gene expression profiling of myeloma cells and of their tumor microenvironment to develop new tumor classifiers, to better understand the bio...

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Hauptverfasser: Mahtouk, Karène (VerfasserIn) , Hose, Dirk (VerfasserIn) , Vos, John de (VerfasserIn) , Moreaux, Jérôme (VerfasserIn) , Jourdan, Michel (VerfasserIn) , Rossi, Jean François (VerfasserIn) , Rème, Thierry (VerfasserIn) , Goldschmidt, Hartmut (VerfasserIn) , Klein, Bernard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 2007
In: Clinical cancer research
Year: 2007, Jahrgang: 13, Heft: 24, Pages: 7289-7295
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-07-1758
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-07-1758
Verlag, lizenzpflichtig, Volltext: https://clincancerres.aacrjournals.org/content/13/24/7289
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Verfasserangaben:Karène Mahtouk, Dirk Hose, John De Vos, Jérôme Moreaux, Michel Jourdan, Jean François Rossi, Thierry Rème, Harmut Goldschmidt, and Bernard Klein
Beschreibung
Zusammenfassung:Multiple myeloma is a B-cell neoplasia characterized by the proliferation of a clone of malignant plasma cells in the bone marrow. We review here the input of gene expression profiling of myeloma cells and of their tumor microenvironment to develop new tumor classifiers, to better understand the biology of myeloma cells, to identify some mechanisms of drug sensitivity and resistance, to identify new myeloma growth factors, and to depict the complex interactions between tumor cells and their microenvironment. We discuss how these findings may improve the clinical outcome of this still incurable disease.
Beschreibung:Gesehen am 21.01.2022
Beschreibung:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-07-1758

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