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Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms

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Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated by neuronal canoni...

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Main Authors: Phelan, Kevin (Author) , Shwe, U. Thaung (Author) , Abramowitz, Joel (Author) , Wu, Hong (Author) , Rhee, Sung W. (Author) , Howell, Matthew D. (Author) , Gottschall, Paul E. (Author) , Freichel, Marc (Author) , Flockerzi, Veit (Author) , Birnbaumer, Lutz (Author) , Zheng, Fang (Author)
Format: Article (Journal)
Language:English
Published: January 17, 2013
In: Molecular pharmacology
Year: 2013, Volume: 83, Issue: 2, Pages: 429-438
ISSN:1521-0111
DOI:10.1124/mol.112.082271
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1124/mol.112.082271
Verlag, lizenzpflichtig, Volltext: https://molpharm.aspetjournals.org/content/83/2/429
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Author Notes:Kevin D. Phelan, U. Thaung Shwe, Joel Abramowitz, Hong Wu, Sung W. Rhee, Matthew D. Howell, Paul E. Gottschall, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer and Fang Zheng
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Odontoblast TRPC5 channels signal cold pain in teeth by Bernal, Laura (Author) , Sotelo-Hitschfeld, Pamela (Author) , König, Christine (Author) , Sinica, Viktor (Author) , Wyatt, Amanda (Author) , Winter, Zoltan (Author) , Hein, Alexander (Author) , Touska, Filip (Author) , Reinhardt, Susanne (Author) , Tragl, Aaron (Author) , Kusuda, Ricardo (Author) , Wartenberg, Philipp (Author) , Sclaroff, Allen (Author) , Pfeifer, John D. (Author) , Ectors, Fabien (Author) , Dahl, Andreas (Author) , Freichel, Marc (Author) , Vlachova, Viktorie (Author) , Brauchi, Sebastian (Author) , Roza, Carolina (Author) , Boehm, Ulrich (Author) , Clapham, David E. (Author) , Lennerz, Jochen K. (Author) , Zimmermann, Katharina (Author) ,


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