ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition
The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures linked to DNA repair defects. Here we demonstrate...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 October 2021
|
| In: |
Nucleic acids research
Year: 2021, Volume: 49, Issue: 20, Pages: 11666-11689 |
| ISSN: | 1362-4962 |
| DOI: | 10.1093/nar/gkab964 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/gkab964
|
| Author Notes: | Ali Bakr, Joschka Hey, Gianluca Sigismondo, Chun-Shan Liu, Ahmed Sadik, Ashish Goyal, Alice Cross, Ramya Lakshmana Iyer, Patrick Müller, Max Trauernicht, Kersten Breuer, Pavlo Lutsik, Christiane A Opitz, Jeroen Krijgsveld, Dieter Weichenhan, Christoph Plass, Odilia Popanda, Peter Schmezer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1787285413 | ||
| 003 | DE-627 | ||
| 005 | 20240415193303.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220127s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/nar/gkab964 |2 doi | |
| 035 | |a (DE-627)1787285413 | ||
| 035 | |a (DE-599)KXP1787285413 | ||
| 035 | |a (OCoLC)1341438975 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bakr, Ali |e VerfasserIn |0 (DE-588)1243151439 |0 (DE-627)1773808451 |4 aut | |
| 245 | 1 | 0 | |a ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition |c Ali Bakr, Joschka Hey, Gianluca Sigismondo, Chun-Shan Liu, Ahmed Sadik, Ashish Goyal, Alice Cross, Ramya Lakshmana Iyer, Patrick Müller, Max Trauernicht, Kersten Breuer, Pavlo Lutsik, Christiane A Opitz, Jeroen Krijgsveld, Dieter Weichenhan, Christoph Plass, Odilia Popanda, Peter Schmezer |
| 264 | 1 | |c 28 October 2021 | |
| 300 | |a 24 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.01.2022 | ||
| 520 | |a The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures linked to DNA repair defects. Here we demonstrate that ID3 exhibits a dual role to promote DNA double-strand break (DSB) repair, particularly homologous recombination (HR). ID3 interacts with the MRN complex and RECQL helicase to activate DSB repair and it facilitates RAD51 loading and downstream steps of HR. In addition, ID3 promotes the expression of HR genes in response to ionizing radiation by regulating both chromatin accessibility and activity of the transcription factor E2F1. Consistently, analyses of TCGA cancer patient data demonstrate that low ID3 expression is associated with impaired HR. The loss of ID3 leads to sensitivity of tumor cells to PARP inhibition, offering new therapeutic opportunities in ID3-deficient tumors. | ||
| 700 | 1 | |a Hey, Joschka |d 1991- |e VerfasserIn |0 (DE-588)1245660896 |0 (DE-627)1777368243 |4 aut | |
| 700 | 1 | |a Sigismondo, Gianluca |e VerfasserIn |0 (DE-588)1162971843 |0 (DE-627)102706504X |0 (DE-576)507717538 |4 aut | |
| 700 | 1 | |a Liu, Chun-Shan |e VerfasserIn |0 (DE-588)1242099174 |0 (DE-627)1772031615 |4 aut | |
| 700 | 1 | |a Sadik, Ahmed |d 1984- |e VerfasserIn |0 (DE-588)1207935387 |0 (DE-627)1694254747 |4 aut | |
| 700 | 1 | |a Goyal, Ashish |e VerfasserIn |0 (DE-588)113560018X |0 (DE-627)890517584 |0 (DE-576)489866425 |4 aut | |
| 700 | 1 | |a Cross, Alice |e VerfasserIn |4 aut | |
| 700 | 1 | |a Iyer, Ramya Lakshmana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Patrick |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trauernicht, Max |e VerfasserIn |4 aut | |
| 700 | 1 | |a Breuer, Kersten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lutsik, Pavlo |e VerfasserIn |0 (DE-588)1176218166 |0 (DE-627)1047372894 |0 (DE-576)516581988 |4 aut | |
| 700 | 1 | |a Opitz, Christiane |d 1979- |e VerfasserIn |0 (DE-588)132405121 |0 (DE-627)522675913 |0 (DE-576)299125041 |4 aut | |
| 700 | 1 | |a Krijgsveld, Jeroen |e VerfasserIn |0 (DE-588)1163292125 |0 (DE-627)1027502032 |0 (DE-576)507882474 |4 aut | |
| 700 | 1 | |a Weichenhan, Dieter |e VerfasserIn |0 (DE-588)1176216201 |0 (DE-627)1047370816 |0 (DE-576)516580582 |4 aut | |
| 700 | 1 | |a Plass, Christoph |d 1961- |e VerfasserIn |0 (DE-588)116753347X |0 (DE-627)1031159894 |0 (DE-576)51118106X |4 aut | |
| 700 | 1 | |a Popanda, Odilia |e VerfasserIn |0 (DE-588)1201385857 |0 (DE-627)1684963338 |4 aut | |
| 700 | 1 | |a Schmezer, Peter |e VerfasserIn |0 (DE-588)1166075133 |0 (DE-627)1029983321 |0 (DE-576)510602606 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nucleic acids research |d Oxford : Oxford Univ. Press, 1974 |g 49(2021), 20, Seite 11666-11689 |h Online-Ressource |w (DE-627)26813250X |w (DE-600)1472175-2 |w (DE-576)07760878X |x 1362-4962 |7 nnas |a ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition |
| 773 | 1 | 8 | |g volume:49 |g year:2021 |g number:20 |g pages:11666-11689 |g extent:24 |a ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition |
| 856 | 4 | 0 | |u https://doi.org/10.1093/nar/gkab964 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220127 | ||
| 994 | |a 2021 | ||
| 998 | |g 1166075133 |a Schmezer, Peter |m 1166075133:Schmezer, Peter |d 140000 |e 140000PS1166075133 |k 0/140000/ |p 18 |y j | ||
| 998 | |g 1201385857 |a Popanda, Odilia |m 1201385857:Popanda, Odilia |d 140000 |e 140000PP1201385857 |k 0/140000/ |p 17 | ||
| 998 | |g 116753347X |a Plass, Christoph |m 116753347X:Plass, Christoph |d 50000 |e 50000PP116753347X |k 0/50000/ |p 16 | ||
| 998 | |g 1176216201 |a Weichenhan, Dieter |m 1176216201:Weichenhan, Dieter |d 140000 |e 140000PW1176216201 |k 0/140000/ |p 15 | ||
| 998 | |g 1163292125 |a Krijgsveld, Jeroen |m 1163292125:Krijgsveld, Jeroen |d 50000 |e 50000PK1163292125 |k 0/50000/ |p 14 | ||
| 998 | |g 132405121 |a Opitz, Christiane |m 132405121:Opitz, Christiane |d 910000 |d 911100 |d 50000 |e 910000PO132405121 |e 911100PO132405121 |e 50000PO132405121 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 13 | ||
| 998 | |g 1176218166 |a Lutsik, Pavlo |m 1176218166:Lutsik, Pavlo |d 140000 |e 140000PL1176218166 |k 0/140000/ |p 12 | ||
| 998 | |g 113560018X |a Goyal, Ashish |m 113560018X:Goyal, Ashish |d 140000 |e 140000PG113560018X |k 0/140000/ |p 6 | ||
| 998 | |g 1207935387 |a Sadik, Ahmed |m 1207935387:Sadik, Ahmed |d 140000 |e 140000PS1207935387 |k 0/140000/ |p 5 | ||
| 998 | |g 1242099174 |a Liu, Chun-Shan |m 1242099174:Liu, Chun-Shan |p 4 | ||
| 998 | |g 1162971843 |a Sigismondo, Gianluca |m 1162971843:Sigismondo, Gianluca |p 3 | ||
| 998 | |g 1245660896 |a Hey, Joschka |m 1245660896:Hey, Joschka |d 140000 |e 140000PH1245660896 |k 0/140000/ |p 2 | ||
| 998 | |g 1243151439 |a Bakr, Ali |m 1243151439:Bakr, Ali |d 140000 |e 140000PB1243151439 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1787285413 |e 4045601996 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"28 October 2021","dateIssuedKey":"2021"}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","family":"Bakr","role":"aut","display":"Bakr, Ali","given":"Ali"},{"role":"aut","display":"Hey, Joschka","given":"Joschka","family":"Hey","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Sigismondo","role":"aut","display":"Sigismondo, Gianluca","given":"Gianluca"},{"roleDisplay":"VerfasserIn","family":"Liu","role":"aut","display":"Liu, Chun-Shan","given":"Chun-Shan"},{"given":"Ahmed","display":"Sadik, Ahmed","role":"aut","family":"Sadik","roleDisplay":"VerfasserIn"},{"display":"Goyal, Ashish","role":"aut","given":"Ashish","roleDisplay":"VerfasserIn","family":"Goyal"},{"display":"Cross, Alice","role":"aut","given":"Alice","roleDisplay":"VerfasserIn","family":"Cross"},{"given":"Ramya Lakshmana","role":"aut","display":"Iyer, Ramya Lakshmana","roleDisplay":"VerfasserIn","family":"Iyer"},{"family":"Müller","roleDisplay":"VerfasserIn","given":"Patrick","display":"Müller, Patrick","role":"aut"},{"family":"Trauernicht","roleDisplay":"VerfasserIn","given":"Max","display":"Trauernicht, Max","role":"aut"},{"family":"Breuer","roleDisplay":"VerfasserIn","given":"Kersten","role":"aut","display":"Breuer, Kersten"},{"given":"Pavlo","role":"aut","display":"Lutsik, Pavlo","family":"Lutsik","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Opitz","given":"Christiane","role":"aut","display":"Opitz, Christiane"},{"role":"aut","display":"Krijgsveld, Jeroen","given":"Jeroen","roleDisplay":"VerfasserIn","family":"Krijgsveld"},{"given":"Dieter","display":"Weichenhan, Dieter","role":"aut","roleDisplay":"VerfasserIn","family":"Weichenhan"},{"given":"Christoph","role":"aut","display":"Plass, Christoph","roleDisplay":"VerfasserIn","family":"Plass"},{"role":"aut","display":"Popanda, Odilia","given":"Odilia","roleDisplay":"VerfasserIn","family":"Popanda"},{"given":"Peter","display":"Schmezer, Peter","role":"aut","roleDisplay":"VerfasserIn","family":"Schmezer"}],"physDesc":[{"extent":"24 S."}],"name":{"displayForm":["Ali Bakr, Joschka Hey, Gianluca Sigismondo, Chun-Shan Liu, Ahmed Sadik, Ashish Goyal, Alice Cross, Ramya Lakshmana Iyer, Patrick Müller, Max Trauernicht, Kersten Breuer, Pavlo Lutsik, Christiane A Opitz, Jeroen Krijgsveld, Dieter Weichenhan, Christoph Plass, Odilia Popanda, Peter Schmezer"]},"relHost":[{"title":[{"title":"Nucleic acids research","title_sort":"Nucleic acids research"}],"id":{"issn":["1362-4962"],"zdb":["1472175-2"],"eki":["26813250X"]},"note":["Gesehen am 15.09.2025","Ungezählte Beil.: Database issue; Web server issue"],"disp":"ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibitionNucleic acids research","part":{"pages":"11666-11689","extent":"24","year":"2021","issue":"20","volume":"49","text":"49(2021), 20, Seite 11666-11689"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisherPlace":"Oxford","dateIssuedKey":"1974","dateIssuedDisp":"1974-","publisher":"Oxford Univ. Press"}],"pubHistory":["1.1974 -"],"titleAlt":[{"title":"NAR online"},{"title":"NAR"},{"title":"Database issue"},{"title":"Web server issue"}],"recId":"26813250X"}],"recId":"1787285413","id":{"eki":["1787285413"],"doi":["10.1093/nar/gkab964"]},"title":[{"title":"ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition","title_sort":"ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition"}],"note":["Gesehen am 27.01.2022"]} | ||
| SRT | |a BAKRALIHEYID3PROMOTE2820 | ||