Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides
The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophore...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 June 2013
|
| In: |
Antimicrobial agents and chemotherapy
Year: 2013, Jahrgang: 57, Heft: 8, Pages: 3917-3922 |
| ISSN: | 1098-6596 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/abs/10.1128/AAC.00862-13
|
| Verfasserangaben: | Marc Swidergall, Andreas M. Ernst, and Joachim F. Ernst |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1787313581 | ||
| 003 | DE-627 | ||
| 005 | 20220820114558.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220127s2013 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1787313581 | ||
| 035 | |a (DE-599)KXP1787313581 | ||
| 035 | |a (OCoLC)1341439496 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Swidergall, Marc |d 1983- |e VerfasserIn |0 (DE-588)1072577607 |0 (DE-627)827778155 |0 (DE-576)434067350 |4 aut | |
| 245 | 1 | 0 | |a Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides |c Marc Swidergall, Andreas M. Ernst, and Joachim F. Ernst |
| 264 | 1 | |c 3 June 2013 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.01.2022 | ||
| 520 | |a The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-affinity binding (dissociation constant [KD] = 73 nM), which was lost or greatly diminished by lack of O-glycosylation or by Msb2* denaturation. Msb2* also interacted with human α- and β-defensins and protected C. albicans against these AMPs. In addition, the lipopeptide antibiotic daptomycin was bound and inactivated by Msb2*, which prevented the killing of bacterial pathogens Staphylococcus aureus, Enterococcus faecalis, and Corynebacterium pseudodiphtheriticum. In coculturings or mixed biofilms of S. aureus with C. albicans wild-type but not msb2 mutant strains, the protective effects of Msb2* on the bactericidal action of daptomycin were demonstrated. These results suggest that tight binding of shed Msb2* to AMPs that occurs during bacterial coinfections with C. albicans compromises antibacterial therapy by inactivating a relevant reserve antibiotic. | ||
| 700 | 1 | |a Ernst, Andreas M. |e VerfasserIn |0 (DE-588)1035799960 |0 (DE-627)749589884 |0 (DE-576)383562503 |4 aut | |
| 700 | 1 | |a Ernst, Joachim F. |d 1949- |e VerfasserIn |0 (DE-588)1146551398 |0 (DE-627)100803374X |0 (DE-576)188061029 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Antimicrobial agents and chemotherapy |d Washington, DC : Soc., 1972 |g 57(2013), 8, Seite 3917-3922 |h Online-Ressource |w (DE-627)306316919 |w (DE-600)1496156-8 |w (DE-576)09718859X |x 1098-6596 |7 nnas |a Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides |
| 773 | 1 | 8 | |g volume:57 |g year:2013 |g number:8 |g pages:3917-3922 |g extent:6 |a Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides |
| 856 | 4 | 0 | |u https://journals.asm.org/doi/abs/10.1128/AAC.00862-13 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220127 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1035799960 |a Ernst, Andreas M. |m 1035799960:Ernst, Andreas M. |d 700000 |d 711000 |d 500000 |d 500638 |e 700000PE1035799960 |e 711000PE1035799960 |e 500000PE1035799960 |e 500638PE1035799960 |k 0/700000/ |k 1/700000/711000/ |k 0/500000/ |k 1/500000/500638/ |p 2 | ||
| 999 | |a KXP-PPN1787313581 |e 4045719970 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Marc Swidergall, Andreas M. Ernst, and Joachim F. Ernst"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"3 June 2013"}],"id":{"eki":["1787313581"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptidesAntimicrobial agents and chemotherapy","note":["Gesehen am 09.06.21"],"recId":"306316919","language":["eng"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"American Society for Microbiology"}],"pubHistory":["1.1972 -"],"titleAlt":[{"title":"AAC"}],"part":{"extent":"6","volume":"57","text":"57(2013), 8, Seite 3917-3922","issue":"8","pages":"3917-3922","year":"2013"},"title":[{"subtitle":"AAC","title":"Antimicrobial agents and chemotherapy","title_sort":"Antimicrobial agents and chemotherapy"}],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["publ. by the American Society for Microbiology"]},"origin":[{"dateIssuedKey":"1972","publisher":"Soc.","dateIssuedDisp":"1972-","publisherPlace":"Washington, DC"}],"id":{"zdb":["1496156-8"],"eki":["306316919"],"issn":["1098-6596"]}}],"person":[{"role":"aut","display":"Swidergall, Marc","roleDisplay":"VerfasserIn","given":"Marc","family":"Swidergall"},{"family":"Ernst","given":"Andreas M.","display":"Ernst, Andreas M.","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Ernst, Joachim F.","roleDisplay":"VerfasserIn","given":"Joachim F.","family":"Ernst"}],"title":[{"title":"Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides","title_sort":"Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 27.01.2022"],"language":["eng"],"recId":"1787313581"} | ||
| SRT | |a SWIDERGALLCANDIDAALB3201 | ||