Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer
Background - The advanced lung cancer inflammation index [ALI: body mass index × serum albumin/neutrophil-to-lymphocyte ratio (NLR)] reflects systemic host inflammation, and is easily reproducible. We hypothesized that ALI could assist guidance of non-small-cell lung cancer (NSCLC) treatment with im...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 September 2021
|
| In: |
ESMO open
Year: 2021, Jahrgang: 6, Heft: 5, Pages: 1-10 |
| ISSN: | 2059-7029 |
| DOI: | 10.1016/j.esmoop.2021.100254 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.esmoop.2021.100254 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2059702921002167 
|
| Verfasserangaben: | G. Mountzios, E. Samantas, K. Senghas, E. Zervas, J. Krisam, K. Samitas, F. Bozorgmehr, J. Kuon, S. Agelaki, S. Baka, I. Athanasiadis, L. Gaissmaier, M. Elshiaty, L. Daniello, A. Christopoulou, G. Pentheroudakis, E. Lianos, H. Linardou, K. Kriegsmann, P. Kosmidis, R. El Shafie, M. Kriegsmann, A. Psyrri, C. Andreadis, E. Fountzilas, C.-P. Heussel, F.J. Herth, H. Winter, C. Emmanouilides, G. Oikonomopoulos, M. Meister, T. Muley, H. Bischoff, Z. Saridaki, E. Razis, E.-I. Perdikouri, A. Stenzinger, I. Boukovinas, M. Reck, K. Syrigos, M. Thomas & P. Christopoulos |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1787339289 | ||
| 003 | DE-627 | ||
| 005 | 20240415193303.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220127s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.esmoop.2021.100254 |2 doi | |
| 035 | |a (DE-627)1787339289 | ||
| 035 | |a (DE-599)KXP1787339289 | ||
| 035 | |a (OCoLC)1341439537 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mountzios, Giannis |e VerfasserIn |0 (DE-588)1225906423 |0 (DE-627)1745946349 |4 aut | |
| 245 | 1 | 0 | |a Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer |c G. Mountzios, E. Samantas, K. Senghas, E. Zervas, J. Krisam, K. Samitas, F. Bozorgmehr, J. Kuon, S. Agelaki, S. Baka, I. Athanasiadis, L. Gaissmaier, M. Elshiaty, L. Daniello, A. Christopoulou, G. Pentheroudakis, E. Lianos, H. Linardou, K. Kriegsmann, P. Kosmidis, R. El Shafie, M. Kriegsmann, A. Psyrri, C. Andreadis, E. Fountzilas, C.-P. Heussel, F.J. Herth, H. Winter, C. Emmanouilides, G. Oikonomopoulos, M. Meister, T. Muley, H. Bischoff, Z. Saridaki, E. Razis, E.-I. Perdikouri, A. Stenzinger, I. Boukovinas, M. Reck, K. Syrigos, M. Thomas & P. Christopoulos |
| 264 | 1 | |c 1 September 2021 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.01.2022 | ||
| 520 | |a Background - The advanced lung cancer inflammation index [ALI: body mass index × serum albumin/neutrophil-to-lymphocyte ratio (NLR)] reflects systemic host inflammation, and is easily reproducible. We hypothesized that ALI could assist guidance of non-small-cell lung cancer (NSCLC) treatment with immune checkpoint inhibitors (ICIs). - Patients and methods - This retrospective study included 672 stage IV NSCLC patients treated with programmed death-ligand 1 (PD-L1) inhibitors alone or in combination with chemotherapy in 25 centers in Greece and Germany, and a control cohort of 444 stage IV NSCLC patients treated with platinum-based chemotherapy without subsequent targeted or immunotherapy drugs. The association of clinical outcomes with biomarkers was analyzed with Cox regression models, including cross-validation by calculation of the Harrell's C-index. - Results - High ALI values (>18) were significantly associated with longer overall survival (OS) for patients receiving ICI monotherapy [hazard ratio (HR) = 0.402, P < 0.0001, n = 460], but not chemo-immunotherapy (HR = 0.624, P = 0.111, n = 212). Similar positive correlations for ALI were observed for objective response rate (36% versus 24%, P = 0.008) and time-on-treatment (HR = 0.52, P < 0.001), in case of ICI monotherapy only. In the control cohort of chemotherapy, the association between ALI and OS was weaker (HR = 0.694, P = 0.0002), and showed a significant interaction with the type of treatment (ICI monotherapy versus chemotherapy, P < 0.0001) upon combined analysis of the two cohorts. In multivariate analysis, ALI had a stronger predictive effect than NLR, PD-L1 tumor proportion score, lung immune prognostic index, and EPSILoN scores. Among patients with PD-L1 tumor proportion score ≥50% receiving first-line ICI monotherapy, a high ALI score >18 identified a subset with longer OS and time-on-treatment (median 35 and 16 months, respectively), similar to these under chemo-immunotherapy. - Conclusions - The ALI score is a powerful prognostic and predictive biomarker for patients with advanced NSCLC treated with PD-L1 inhibitors alone, but not in combination with chemotherapy. Its association with outcomes appears to be stronger than that of other widely used parameters. For PD-L1-high patients, an ALI score >18 could assist the selection of cases that do not need addition of chemotherapy. | ||
| 650 | 4 | |a advanced lung cancer inflammation index | |
| 650 | 4 | |a immunotherapy | |
| 650 | 4 | |a neutrophil-to-lymphocyte ratio | |
| 650 | 4 | |a non-small-cell lung cancer | |
| 650 | 4 | |a PD-L1 | |
| 700 | 1 | |a Samantas, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Senghas, Karsten |e VerfasserIn |0 (DE-588)1210442388 |0 (DE-627)1698468938 |4 aut | |
| 700 | 1 | |a Zervas, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krisam, Johannes |d 1986- |e VerfasserIn |0 (DE-588)1016031343 |0 (DE-627)705475034 |0 (DE-576)351438696 |4 aut | |
| 700 | 1 | |a Samitas, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bozorgmehr, Farastuk |d 1979- |e VerfasserIn |0 (DE-588)141921811 |0 (DE-627)632526734 |0 (DE-576)326848150 |4 aut | |
| 700 | 1 | |a Kuon, Jonas |e VerfasserIn |0 (DE-588)1166909484 |0 (DE-627)1030803730 |0 (DE-576)510963129 |4 aut | |
| 700 | 1 | |a Agelaki, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baka, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Athanasiadis, I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gaißmaier, Lena |d 1996- |e VerfasserIn |0 (DE-588)1250460697 |0 (DE-627)1787337537 |4 aut | |
| 700 | 1 | |a Elshiaty, Mariam |e VerfasserIn |0 (DE-588)1237666333 |0 (DE-627)1764596110 |4 aut | |
| 700 | 1 | |a Daniello, Lea |d 1997- |e VerfasserIn |0 (DE-588)1238304303 |0 (DE-627)1765667739 |4 aut | |
| 700 | 1 | |a Christopoulou, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pentheroudakis, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lianos, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Linardou, H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kriegsmann, Katharina |d 1986- |e VerfasserIn |0 (DE-588)1049422449 |0 (DE-627)781924006 |0 (DE-576)40339774X |4 aut | |
| 700 | 1 | |a Kosmidis, P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a El-Shafie, Rami |d 1989- |e VerfasserIn |0 (DE-588)110057378X |0 (DE-627)859521427 |0 (DE-576)469743859 |4 aut | |
| 700 | 1 | |a Kriegsmann, Mark |d 1987- |e VerfasserIn |0 (DE-588)103740324X |0 (DE-627)755668782 |0 (DE-576)39141870X |4 aut | |
| 700 | 1 | |a Psyrri, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andreadis, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fountzilas, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heußel, Claus Peter |e VerfasserIn |0 (DE-588)1048631389 |0 (DE-627)780769422 |0 (DE-576)40288146X |4 aut | |
| 700 | 1 | |a Herth, Felix |e VerfasserIn |0 (DE-588)1016095236 |0 (DE-627)705477568 |0 (DE-576)351509925 |4 aut | |
| 700 | 1 | |a Winter, Hauke |e VerfasserIn |0 (DE-588)1162076038 |0 (DE-627)1025509773 |0 (DE-576)176791531 |4 aut | |
| 700 | 1 | |a Emmanouilides, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oikonomopoulos, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meister, Michael |e VerfasserIn |0 (DE-588)1078792046 |0 (DE-627)839461402 |0 (DE-576)451890108 |4 aut | |
| 700 | 1 | |a Muley, Thomas |e VerfasserIn |0 (DE-588)1056885432 |0 (DE-627)794179169 |0 (DE-576)16759284X |4 aut | |
| 700 | 1 | |a Bischoff, Helge |d 1958- |e VerfasserIn |0 (DE-588)111184576 |0 (DE-627)389658286 |0 (DE-576)167287249 |4 aut | |
| 700 | 1 | |a Saridaki, Z. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Razis, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Perdikouri, E. -I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 700 | 1 | |a Boukovinas, I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reck, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Syrigos, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thomas, Michael |e VerfasserIn |0 (DE-588)1054438781 |0 (DE-627)79152213X |0 (DE-576)41027089X |4 aut | |
| 700 | 1 | |a Christopoulos, Petros |d 1977- |e VerfasserIn |0 (DE-588)138659702 |0 (DE-627)604886756 |0 (DE-576)308488067 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ESMO open |d [London] : Elsevier, 2016 |g 6(2021), 5, Artikel-ID 100254, Seite 1-10 |h Online-Ressource |w (DE-627)84705344X |w (DE-600)2844985-X |w (DE-576)454658516 |x 2059-7029 |7 nnas |a Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer |
| 773 | 1 | 8 | |g volume:6 |g year:2021 |g number:5 |g elocationid:100254 |g pages:1-10 |g extent:10 |a Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.esmoop.2021.100254 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2059702921002167 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220127 | ||
| 992 | |a 20220127 | ||
| 993 | |a Article | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 994 | |a 2021 | ||
| 998 | |g 138659702 |a Christopoulos, Petros |m 138659702:Christopoulos, Petros |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PC138659702 |e 950000PC138659702 |e 950900PC138659702 |e 50000PC138659702 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 42 |y j | ||
| 998 | |g 1054438781 |a Thomas, Michael |m 1054438781:Thomas, Michael |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PT1054438781 |e 950000PT1054438781 |e 950900PT1054438781 |e 50000PT1054438781 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 41 | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |e 910000PS139606106 |e 912000PS139606106 |k 0/910000/ |k 1/910000/912000/ |p 37 | ||
| 998 | |g 111184576 |a Bischoff, Helge |m 111184576:Bischoff, Helge |d 910000 |d 950000 |d 950900 |e 910000PB111184576 |e 950000PB111184576 |e 950900PB111184576 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 33 | ||
| 998 | |g 1056885432 |a Muley, Thomas |m 1056885432:Muley, Thomas |d 910000 |d 950000 |d 950900 |e 910000PM1056885432 |e 950000PM1056885432 |e 950900PM1056885432 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 32 | ||
| 998 | |g 1078792046 |a Meister, Michael |m 1078792046:Meister, Michael |d 910000 |d 950000 |d 950900 |e 910000PM1078792046 |e 950000PM1078792046 |e 950900PM1078792046 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 31 | ||
| 998 | |g 1162076038 |a Winter, Hauke |m 1162076038:Winter, Hauke |d 50000 |e 50000PW1162076038 |k 0/50000/ |p 28 | ||
| 998 | |g 1016095236 |a Herth, Felix |m 1016095236:Herth, Felix |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PH1016095236 |e 950000PH1016095236 |e 950900PH1016095236 |e 50000PH1016095236 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 27 | ||
| 998 | |g 1048631389 |a Heußel, Claus Peter |m 1048631389:Heußel, Claus Peter |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PH1048631389 |e 950000PH1048631389 |e 950900PH1048631389 |e 50000PH1048631389 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 26 | ||
| 998 | |g 103740324X |a Kriegsmann, Mark |m 103740324X:Kriegsmann, Mark |d 910000 |d 912000 |d 50000 |e 910000PK103740324X |e 912000PK103740324X |e 50000PK103740324X |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 22 | ||
| 998 | |g 110057378X |a El-Shafie, Rami |m 110057378X:El-Shafie, Rami |d 50000 |e 50000PE110057378X |k 0/50000/ |p 21 | ||
| 998 | |g 1049422449 |a Kriegsmann, Katharina |m 1049422449:Kriegsmann, Katharina |d 910000 |d 910100 |e 910000PK1049422449 |e 910100PK1049422449 |k 0/910000/ |k 1/910000/910100/ |p 19 | ||
| 998 | |g 1238304303 |a Daniello, Lea |m 1238304303:Daniello, Lea |d 50000 |e 50000PD1238304303 |k 0/50000/ |p 14 | ||
| 998 | |g 1237666333 |a Elshiaty, Mariam |m 1237666333:Elshiaty, Mariam |d 50000 |e 50000PE1237666333 |k 0/50000/ |p 13 | ||
| 998 | |g 1250460697 |a Gaißmaier, Lena |m 1250460697:Gaißmaier, Lena |d 50000 |e 50000PG1250460697 |k 0/50000/ |p 12 | ||
| 998 | |g 1166909484 |a Kuon, Jonas |m 1166909484:Kuon, Jonas |d 50000 |e 50000PK1166909484 |k 0/50000/ |p 8 | ||
| 998 | |g 141921811 |a Bozorgmehr, Farastuk |m 141921811:Bozorgmehr, Farastuk |d 910000 |d 950000 |d 950900 |e 910000PB141921811 |e 950000PB141921811 |e 950900PB141921811 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 7 | ||
| 998 | |g 1016031343 |a Krisam, Johannes |m 1016031343:Krisam, Johannes |d 910000 |d 911800 |e 910000PK1016031343 |e 911800PK1016031343 |k 0/910000/ |k 1/910000/911800/ |p 5 | ||
| 998 | |g 1210442388 |a Senghas, Karsten |m 1210442388:Senghas, Karsten |d 910000 |d 950000 |d 950900 |e 910000PS1210442388 |e 950000PS1210442388 |e 950900PS1210442388 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 3 | ||
| 999 | |a KXP-PPN1787339289 |e 404596665X | ||
| 999 | |a KXP-PPN1787339289 |e 4045966641 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 27.01.2022"],"origin":[{"dateIssuedDisp":"1 September 2021","dateIssuedKey":"2021"}],"title":[{"title_sort":"Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer","title":"Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancer"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["G. Mountzios, E. Samantas, K. Senghas, E. Zervas, J. Krisam, K. Samitas, F. Bozorgmehr, J. Kuon, S. Agelaki, S. Baka, I. Athanasiadis, L. Gaissmaier, M. Elshiaty, L. Daniello, A. Christopoulou, G. Pentheroudakis, E. Lianos, H. Linardou, K. Kriegsmann, P. Kosmidis, R. El Shafie, M. Kriegsmann, A. Psyrri, C. Andreadis, E. Fountzilas, C.-P. Heussel, F.J. Herth, H. Winter, C. Emmanouilides, G. Oikonomopoulos, M. Meister, T. Muley, H. Bischoff, Z. Saridaki, E. Razis, E.-I. Perdikouri, A. Stenzinger, I. Boukovinas, M. Reck, K. Syrigos, M. Thomas & P. Christopoulos"]},"physDesc":[{"extent":"10 S."}],"relHost":[{"part":{"volume":"6","extent":"10","text":"6(2021), 5, Artikel-ID 100254, Seite 1-10","issue":"5","pages":"1-10","year":"2021"},"language":["eng"],"corporate":[{"role":"isb","display":"European Society for Medical Oncology"}],"id":{"zdb":["2844985-X"],"issn":["2059-7029"],"eki":["84705344X"]},"recId":"84705344X","name":{"displayForm":["European Society for Medical Oncology"]},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Association of the advanced lung cancer inflammation index (ALI) with immune checkpoint inhibitor efficacy in patients with advanced non-small-cell lung cancerESMO open","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 13.06.24"],"pubHistory":["1.2016 -"],"origin":[{"publisherPlace":"[London] ; London","dateIssuedDisp":"2016-","dateIssuedKey":"2016","publisher":"Elsevier ; BMJ"}],"title":[{"title_sort":"ESMO open","subtitle":"cancer horizons","title":"ESMO open"}]}],"recId":"1787339289","id":{"doi":["10.1016/j.esmoop.2021.100254"],"eki":["1787339289"]},"person":[{"given":"Giannis","role":"aut","family":"Mountzios","display":"Mountzios, Giannis"},{"display":"Samantas, E.","family":"Samantas","given":"E.","role":"aut"},{"display":"Senghas, Karsten","family":"Senghas","role":"aut","given":"Karsten"},{"role":"aut","given":"E.","display":"Zervas, E.","family":"Zervas"},{"role":"aut","given":"Johannes","display":"Krisam, Johannes","family":"Krisam"},{"family":"Samitas","display":"Samitas, K.","given":"K.","role":"aut"},{"family":"Bozorgmehr","display":"Bozorgmehr, Farastuk","given":"Farastuk","role":"aut"},{"role":"aut","given":"Jonas","display":"Kuon, Jonas","family":"Kuon"},{"family":"Agelaki","display":"Agelaki, S.","given":"S.","role":"aut"},{"role":"aut","given":"S.","family":"Baka","display":"Baka, S."},{"family":"Athanasiadis","display":"Athanasiadis, I.","role":"aut","given":"I."},{"role":"aut","given":"Lena","display":"Gaißmaier, Lena","family":"Gaißmaier"},{"role":"aut","given":"Mariam","display":"Elshiaty, Mariam","family":"Elshiaty"},{"display":"Daniello, Lea","family":"Daniello","role":"aut","given":"Lea"},{"given":"A.","role":"aut","display":"Christopoulou, A.","family":"Christopoulou"},{"given":"G.","role":"aut","family":"Pentheroudakis","display":"Pentheroudakis, G."},{"given":"E.","role":"aut","display":"Lianos, E.","family":"Lianos"},{"given":"H.","role":"aut","family":"Linardou","display":"Linardou, H."},{"display":"Kriegsmann, Katharina","family":"Kriegsmann","role":"aut","given":"Katharina"},{"display":"Kosmidis, P.","family":"Kosmidis","given":"P.","role":"aut"},{"given":"Rami","role":"aut","display":"El-Shafie, Rami","family":"El-Shafie"},{"role":"aut","given":"Mark","family":"Kriegsmann","display":"Kriegsmann, Mark"},{"given":"A.","role":"aut","family":"Psyrri","display":"Psyrri, A."},{"given":"C.","role":"aut","family":"Andreadis","display":"Andreadis, C."},{"given":"E.","role":"aut","family":"Fountzilas","display":"Fountzilas, E."},{"display":"Heußel, Claus Peter","family":"Heußel","role":"aut","given":"Claus Peter"},{"display":"Herth, Felix","family":"Herth","role":"aut","given":"Felix"},{"display":"Winter, Hauke","family":"Winter","role":"aut","given":"Hauke"},{"given":"C.","role":"aut","family":"Emmanouilides","display":"Emmanouilides, C."},{"family":"Oikonomopoulos","display":"Oikonomopoulos, G.","role":"aut","given":"G."},{"role":"aut","given":"Michael","family":"Meister","display":"Meister, Michael"},{"family":"Muley","display":"Muley, Thomas","role":"aut","given":"Thomas"},{"display":"Bischoff, Helge","family":"Bischoff","given":"Helge","role":"aut"},{"family":"Saridaki","display":"Saridaki, Z.","given":"Z.","role":"aut"},{"role":"aut","given":"E.","display":"Razis, E.","family":"Razis"},{"role":"aut","given":"E. -I.","family":"Perdikouri","display":"Perdikouri, E. -I."},{"given":"Albrecht","role":"aut","display":"Stenzinger, Albrecht","family":"Stenzinger"},{"family":"Boukovinas","display":"Boukovinas, I.","role":"aut","given":"I."},{"family":"Reck","display":"Reck, M.","role":"aut","given":"M."},{"display":"Syrigos, K.","family":"Syrigos","role":"aut","given":"K."},{"role":"aut","given":"Michael","family":"Thomas","display":"Thomas, Michael"},{"family":"Christopoulos","display":"Christopoulos, Petros","given":"Petros","role":"aut"}],"language":["eng"]} | ||
| SRT | |a MOUNTZIOSGASSOCIATIO1202 | ||