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Microarray-based understanding of normal and malignant plasma cells

Summary: Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surfa...

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Bibliographische Detailangaben
Hauptverfasser: De Vos, John (VerfasserIn) , Hose, Dirk (VerfasserIn) , Rème, Thierry (VerfasserIn) , Tarte, Karin (VerfasserIn) , Moreaux, Jérôme (VerfasserIn) , Mahtouk, Karéne (VerfasserIn) , Jourdan, Michel (VerfasserIn) , Goldschmidt, Hartmut (VerfasserIn) , Rossi, Jean-François (VerfasserIn) , Cremer, Friedrich Walter (VerfasserIn) , Klein, Bernard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 March 2006
In: Immunological reviews
Year: 2006, Jahrgang: 210, Heft: 1, Pages: 86-104
ISSN:1600-065X
DOI:10.1111/j.0105-2896.2006.00362.x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.0105-2896.2006.00362.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0105-2896.2006.00362.x
Volltext
Verfasserangaben:John De Vos, Dirk Hose, Thierry Rème, Karin Tarte, Jérôme Moreaux, Karéne Mahtouk, Michel Jourdan, Hartmut Goldschmidt, Jean-François Rossi, Friedrich W. Cremer, Bernard Klein
Beschreibung
Zusammenfassung:Summary: Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.
Beschreibung:Gesehen am 28.01.2022
Beschreibung:Online Resource
ISSN:1600-065X
DOI:10.1111/j.0105-2896.2006.00362.x

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