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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood.

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Main Authors: Bull, Caroline J. (Author) , Bell, Joshua A. (Author) , Murphy, Neil (Author) , Sanderson, Eleanor (Author) , Davey Smith, George (Author) , Timpson, Nicholas J. (Author) , Banbury, Barbara L. (Author) , Albanes, Demetrius (Author) , Berndt, Sonja I. (Author) , Bézieau, Stéphane (Author) , Bishop, D. Timothy (Author) , Brenner, Hermann (Author) , Buchanan, Daniel D. (Author) , Burnett-Hartman, Andrea (Author) , Casey, Graham (Author) , Castellví-Bel, Sergi (Author) , Chan, Andrew T. (Author) , Chang-Claude, Jenny (Author) , Cross, Amanda J. (Author) , de la Chapelle, Albert (Author) , Figueiredo, Jane C. (Author) , Gallinger, Steven J. (Author) , Gapstur, Susan M. (Author) , Giles, Graham G. (Author) , Gruber, Stephen B. (Author) , Gsur, Andrea (Author) , Hampe, Jochen (Author) , Hampel, Heather (Author) , Harrison, Tabitha A. (Author) , Hoffmeister, Michael (Author) , Hsu, Li (Author) , Huang, Wen-Yi (Author) , Huyghe, Jeroen R. (Author) , Jenkins, Mark A. (Author) , Joshu, Corinne E. (Author) , Keku, Temitope O. (Author) , Kühn, Tilman (Author) , Kweon, Sun-Seog (Author) , Le Marchand, Loic (Author) , Li, Christopher I. (Author) , Li, Li (Author) , Lindblom, Annika (Author) , Martín, Vicente (Author) , May, Anne M. (Author) , Milne, Roger L. (Author) , Moreno, Victor (Author) , Newcomb, Polly A. (Author) , Offit, Kenneth (Author) , Ogino, Shuji (Author) , Phipps, Amanda I. (Author) , Platz, Elizabeth A. (Author) , Potter, John D. (Author) , Qu, Conghui (Author) , Quirós, J. Ramón (Author) , Rennert, Gad (Author) , Riboli, Elio (Author) , Sakoda, Lori C. (Author) , Schafmayer, Clemens (Author) , Schoen, Robert E. (Author) , Slattery, Martha L. (Author) , Tangen, Catherine M. (Author) , Tsilidis, Kostas K. (Author) , Ulrich, Cornelia M. (Author) , van Duijnhoven, Fränzel J. B. (Author) , van Guelpen, Bethany (Author) , Visvanathan, Kala (Author) , Vodicka, Pavel (Author) , Vodickova, Ludmila (Author) , Wang, Hansong (Author) , White, Emily (Author) , Wolk, Alicja (Author) , Woods, Michael O. (Author) , Wu, Anna H. (Author) , Campbell, Peter T. (Author) , Zheng, Wei (Author) , Peters, Ulrike (Author) , Vincent, Emma E. (Author) , Gunter, Marc J. (Author)
Format: Article (Journal)
Language:English
Published: 17 December 2020
In: BMC medicine
Year: 2020, Volume: 18, Pages: 1-16
ISSN:1741-7015
DOI:10.1186/s12916-020-01855-9
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12916-020-01855-9
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Author Notes:Caroline J. Bull, Joshua A. Bell, Neil Murphy, Eleanor Sanderson, George Davey Smith, Nicholas J. Timpson, Barbara L. Banbury, Demetrius Albanes, Sonja I. Berndt, Stéphane Bézieau, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Andrea Burnett-Hartman, Graham Casey, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Amanda J. Cross, Albert de la Chapelle, Jane C. Figueiredo, Steven J. Gallinger, Susan M. Gapstur, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Tabitha A. Harrison, Michael Hoffmeister, Li Hsu, Wen-Yi Huang, Jeroen R. Huyghe, Mark A. Jenkins, Corinne E. Joshu, Temitope O. Keku, Tilman Kühn, Sun-Seog Kweon, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Vicente Martín, Anne M. May, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Shuji Ogino, Amanda I. Phipps, Elizabeth A. Platz, John D. Potter, Conghui Qu, J. Ramón Quirós, Gad Rennert, Elio Riboli, Lori C. Sakoda, Clemens Schafmayer, Robert E. Schoen, Martha L. Slattery, Catherine M. Tangen, Kostas K. Tsilidis, Cornelia M. Ulrich, Fränzel J.B. van Duijnhoven, Bethany van Guelpen, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Hansong Wang, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Peter T. Campbell, Wei Zheng, Ulrike Peters, Emma E. Vincent and Marc J. Gunter
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Summary:Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood.
Item Description:Gesehen am 02.02.2022
Physical Description:Online Resource
ISSN:1741-7015
DOI:10.1186/s12916-020-01855-9

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