Domino decarboxylative arylation and c-o selective bond formation toward chromeno(2,3-b)pyridine-2-one skeletons
Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno(2,3-b)pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic s...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 8, 2021
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| In: |
The journal of organic chemistry
Year: 2021, Jahrgang: 86, Heft: 18, Pages: 12705-12713 |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/acs.joc.1c01220 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.joc.1c01220
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| Verfasserangaben: | Elmira Meghrazi Ahadi, Alireza Abbasi Kejani, Hormoz Khosravi, Vaezeh Fathi Vavsari, Saeed Balalaie, Frank Rominger, and Hamid Reza Bijanzadeh |
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| 520 | |a Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno(2,3-b)pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic skeletons via selective C-O bond formation and decarboxylative arylation in a single step with high selectivity and good yields. | ||
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