Buchumschlag

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay

The exon junction complex (EJC) participates in the regulation of many post-transcriptional steps of gene expression. EJCs are deposited on messenger RNAs (mRNAs) during splicing and their core consists of eIF4A3, MLN51, Y14, and MAGOH. Here, we show that two genes encoding MAGOH paralogs (referred...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Singh, Kusum Kumari (VerfasserIn) , Wachsmuth, Laurens (VerfasserIn) , Kulozik, Andreas (VerfasserIn) , Gehring, Niels H (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2013
In: RNA biology
Year: 2013, Jahrgang: 10, Heft: 8, Pages: 1291-1298
ISSN:1555-8584
DOI:10.4161/rna.25827
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.4161/rna.25827
Verlag, kostenfrei, Volltext: https://www.tandfonline.com/doi/full/10.4161/rna.25827
Volltext
Verfasserangaben:Kusum K Singh, Laurens Wachsmuth, Andreas E Kulozik, and Niels H Gehring

MARC

LEADER 00000caa a2200000 c 4500
001 1788362632
003 DE-627
005 20220820121353.0
007 cr uuu---uuuuu
008 220202s2013 xx |||||o 00| ||eng c
024 7 |a 10.4161/rna.25827  |2 doi 
035 |a (DE-627)1788362632 
035 |a (DE-599)KXP1788362632 
035 |a (OCoLC)1341441279 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Singh, Kusum Kumari  |d 1979-  |e VerfasserIn  |0 (DE-588)13725573X  |0 (DE-627)591038021  |0 (DE-576)30283706X  |4 aut 
245 1 0 |a Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay  |c Kusum K Singh, Laurens Wachsmuth, Andreas E Kulozik, and Niels H Gehring 
264 1 |c 2013 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Published online: 23 Jul 2013 
500 |a Gesehen am 02.02.2022 
520 |a The exon junction complex (EJC) participates in the regulation of many post-transcriptional steps of gene expression. EJCs are deposited on messenger RNAs (mRNAs) during splicing and their core consists of eIF4A3, MLN51, Y14, and MAGOH. Here, we show that two genes encoding MAGOH paralogs (referred to as MAGOH and MAGOHB) are expressed in mammals. In macrophages, the expression of MAGOHB, but not MAGOH mRNA, increases rapidly after LPS stimulation. Both MAGOH proteins interact with other EJC components, incorporate into mRNA-bound EJCs, and activate nonsense-mediated decay. Furthermore, the simultaneous depletion of MAGOH and MAGOHB, but not individual depletions, impair nonsense-mediated decay in human cells. Hence, our results establish that the core composition of mammalian EJCs is more complex than previously recognized. 
650 4 |a EJC 
650 4 |a gene duplication 
650 4 |a mago nashi homolog 
650 4 |a MAGOHB 
650 4 |a NMD 
700 1 |a Wachsmuth, Laurens  |e VerfasserIn  |4 aut 
700 1 |a Kulozik, Andreas  |d 1959-  |e VerfasserIn  |0 (DE-588)1025736567  |0 (DE-627)723892032  |0 (DE-576)167091638  |4 aut 
700 1 |a Gehring, Niels H  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t RNA biology  |d Philadelphia, Pa. : Taylor & Francis, 2004  |g 10(2013), 8, Seite 1291-1298  |h Online-Ressource  |w (DE-627)393747174  |w (DE-600)2159587-2  |w (DE-576)321220188  |x 1555-8584  |7 nnas  |a Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay 
773 1 8 |g volume:10  |g year:2013  |g number:8  |g pages:1291-1298  |g extent:8  |a Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay 
856 4 0 |u https://doi.org/10.4161/rna.25827  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.tandfonline.com/doi/full/10.4161/rna.25827  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20220202 
993 |a Article 
994 |a 2013 
998 |g 1025736567  |a Kulozik, Andreas  |m 1025736567:Kulozik, Andreas  |d 910000  |d 910500  |e 910000PK1025736567  |e 910500PK1025736567  |k 0/910000/  |k 1/910000/910500/  |p 3 
999 |a KXP-PPN1788362632  |e 4050132583 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Published online: 23 Jul 2013","Gesehen am 02.02.2022"],"relHost":[{"note":["Gesehen am 17.08.2020"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"pubHistory":["1.2004 -"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"RNA biology","title_sort":"RNA biology"}],"recId":"393747174","disp":"Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decayRNA biology","origin":[{"dateIssuedKey":"2004","publisher":"Taylor & Francis ; Landes Bioscience","dateIssuedDisp":"2004-","publisherPlace":"Philadelphia, Pa. ; Georgetown, Tex."}],"id":{"issn":["1555-8584"],"zdb":["2159587-2"],"eki":["393747174"]},"part":{"pages":"1291-1298","volume":"10","extent":"8","text":"10(2013), 8, Seite 1291-1298","year":"2013","issue":"8"}}],"physDesc":[{"extent":"8 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","given":"Kusum Kumari","family":"Singh","display":"Singh, Kusum Kumari"},{"role":"aut","given":"Laurens","family":"Wachsmuth","display":"Wachsmuth, Laurens"},{"display":"Kulozik, Andreas","family":"Kulozik","role":"aut","given":"Andreas"},{"display":"Gehring, Niels H","family":"Gehring","role":"aut","given":"Niels H"}],"title":[{"title_sort":"Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay","title":"Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay"}],"name":{"displayForm":["Kusum K Singh, Laurens Wachsmuth, Andreas E Kulozik, and Niels H Gehring"]},"recId":"1788362632","id":{"eki":["1788362632"],"doi":["10.4161/rna.25827"]},"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}]} 
SRT |a SINGHKUSUMTWOMAMMALI2013 

Ähnliche Einträge