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Epigenetic inactivation of the tumor suppressor IRX1 occurs frequently in lung sdenocarcinoma and its silencing is sssociated with impaired prognosis

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Iroquois homeobox (IRX) encodes members of homeodomain containing genes which are involved in development and differentiation. Since it has been reported that the IRX1 gene is localized in a lung cancer susceptibility locus, the epigenetic regulation and function of IRX1 was investigated in lung car...

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Autores principales: Küster, Miriam M. (Autor) , Schneider, Marc (Autor) , Richter, Antje M. (Autor) , Richtmann, Sarah (Autor) , Winter, Hauke (Autor) , Kriegsmann, Mark (Autor) , Pullamsetti, Soni S. (Autor) , Stiewe, Thorsten (Autor) , Savai, Rajkumar (Autor) , Muley, Thomas (Autor) , Dammann, Reinhard H. (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 26 November 2020
In: Cancers
Year: 2020, Volumen: 12, Número: 12, Pages: 1-19
ISSN:2072-6694
DOI:10.3390/cancers12123528
Acceso en línea:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers12123528
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/12/12/3528
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Notas de Autor:Miriam M. Küster, Marc A. Schneider, Antje M. Richter, Sarah Richtmann, Hauke Winter, Mark Kriegsmann, Soni S. Pullamsetti, Thorsten Stiewe, Rajkumar Savai, Thomas Muley and Reinhard H. Dammann
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Identification of a novel RSPO1-NUMT insertion in a LUAD patient cohort and the challenges and insights into NUMT detection highlighting the importance of reference genomes and pop... por Tietzová, Ilona (Autor) , Sochorova, Dana (Autor) , Triska, Petr (Autor) , Rancourt, Rebecca C. (Autor) , Omelka, Marek (Autor) , Parobkova, Eva (Autor) , Allgäuer, Michael (Autor) , Schneider, Marc (Autor) , Senghas, Karsten (Autor) , Klotz, Laura Valentina (Autor) , Tesarova, Marketa (Autor) ,


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Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: first clinical experience por Eichhorn, Florian (Autor) , Klotz, Laura Valentina (Autor) , Kriegsmann, Mark (Autor) , Bischoff, Helge (Autor) , Schneider, Marc (Autor) , Muley, Thomas (Autor) , Kriegsmann, Katharina (Autor) , Haberkorn, Uwe (Autor) , Heußel, Claus Peter (Autor) , Savai, Rajkumar (Autor) , Zörnig, Inka (Autor) , Jäger, Dirk (Autor) , Thomas, Michael (Autor) , Hoffmann, Hans (Autor) , Winter, Hauke (Autor) , Eichhorn, Martin E. (Autor) ,


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Prognostic relevance of regional lymph-node distribution in patients with N1-positive non-small cell lung cancer: a retrospective single-center analysis por Eichhorn, Florian (Autor) , Klotz, Laura Valentina (Autor) , Muley, Thomas (Autor) , Kobinger, Sonja (Autor) , Winter, Hauke (Autor) , Eichhorn, Martin E. (Autor) ,


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