Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143T
The purpose of this study is to examine alterations of the peripheral nervous system (PNS) in oligo-symptomatic patients carrying the Fabry related GLA-gene variant p.A143T by Magnetic Resonance Neurography (MRN) and skin biopsy. This prospective study assessed dorsal root ganglia (DRG) volume L3 to...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 November 2020
|
| In: |
Diagnostics
Year: 2020, Jahrgang: 10, Heft: 12, Pages: 1-11 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics10121027 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics10121027 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/10/12/1027 
|
| Verfasserangaben: | Tim Godel, Katharina von Cossel, Reinhard E. Friedrich, Markus Glatzel, Sima Canaan-Kühl, Thomas Duning, Moritz Kronlage, Sabine Heiland, Martin Bendszus, Nicole Muschol and Victor-Felix Mautner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1788786580 | ||
| 003 | DE-627 | ||
| 005 | 20230427162745.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220208s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/diagnostics10121027 |2 doi | |
| 035 | |a (DE-627)1788786580 | ||
| 035 | |a (DE-599)KXP1788786580 | ||
| 035 | |a (OCoLC)1341441429 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Godel, Tim |d 1985- |e VerfasserIn |0 (DE-588)1153513471 |0 (DE-627)1014950384 |0 (DE-576)500281394 |4 aut | |
| 245 | 1 | 0 | |a Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143T |c Tim Godel, Katharina von Cossel, Reinhard E. Friedrich, Markus Glatzel, Sima Canaan-Kühl, Thomas Duning, Moritz Kronlage, Sabine Heiland, Martin Bendszus, Nicole Muschol and Victor-Felix Mautner |
| 246 | 3 | 0 | |a one hundred and forty-three |
| 264 | 1 | |c 30 November 2020 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.02.2022 | ||
| 520 | |a The purpose of this study is to examine alterations of the peripheral nervous system (PNS) in oligo-symptomatic patients carrying the Fabry related GLA-gene variant p.A143T by Magnetic Resonance Neurography (MRN) and skin biopsy. This prospective study assessed dorsal root ganglia (DRG) volume L3 to S2, vascular permeability of the DRG L5, S1, and the spinal nerve L5 in five patients carrying p.A143T in comparison to patients with classical Fabry mutations and healthy controls. Moreover, skin punch biopsies above the lateral malleolus of the right foot were obtained in four patients and intraepidermal nerve fiber density (IENFD) was counted individually. Compared to controls, DRG volumes of p.A143T patients were enlarged by 30% (L3, p < 0.05), 35% (L4, p < 0.05), 29% (L5, p = 0.15), 36% (S1, p < 0.01), and 18% (S2, p < 0.05), but less pronounced compared to patients carrying a classical Fabry mutation. Compared to healthy controls, vascular permeability was decreased by 40% (L5 right), 49% (L5 left), 48% (S1 right), and 49% (S1) (p < 0.01-p < 0.001), but non-significant less than patients carrying a classical Fabry mutation. Compared to sex-matched 5% lower normative reference values per decade, IENFD was decreased in three of four patients. MRN and determination of IENFD is able to detect early alteration of the PNS segment in oligo-symptomatic patients with the disease-modifying GLA-variant p.A143T on an individual basis. This procedure might also help in further GLA-variants of uncertain significance for early identification of patients with single major organ manifestation. | ||
| 650 | 4 | |a dorsal root ganglia | |
| 650 | 4 | |a Fabry disease | |
| 650 | 4 | |a Magnetic Resonance Neurography | |
| 650 | 4 | |a neuropathic pain | |
| 650 | 4 | |a peripheral neuropathy | |
| 700 | 1 | |a Cossel, Katharina von |e VerfasserIn |4 aut | |
| 700 | 1 | |a Friedrich, Reinhard E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Glatzel, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Canaan-Kühl, Sima |e VerfasserIn |4 aut | |
| 700 | 1 | |a Duning, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kronlage, Moritz |d 1984- |e VerfasserIn |0 (DE-588)1027093531 |0 (DE-627)728260050 |0 (DE-576)37246887X |4 aut | |
| 700 | 1 | |a Heiland, Sabine |e VerfasserIn |0 (DE-588)106732626X |0 (DE-627)818624450 |0 (DE-576)426561368 |4 aut | |
| 700 | 1 | |a Bendszus, Martin |e VerfasserIn |0 (DE-588)1032676426 |0 (DE-627)738634131 |0 (DE-576)175567697 |4 aut | |
| 700 | 1 | |a Muschol, Nicole |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mautner, Victor-Felix |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diagnostics |d Basel : MDPI, 2011 |g 10(2020), 12, Artikel-ID 1027, Seite 1-11 |h Online-Ressource |w (DE-627)718627814 |w (DE-600)2662336-5 |w (DE-576)365413917 |x 2075-4418 |7 nnas |a Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143T |
| 773 | 1 | 8 | |g volume:10 |g year:2020 |g number:12 |g elocationid:1027 |g pages:1-11 |g extent:11 |a Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143T |
| 856 | 4 | 0 | |u https://doi.org/10.3390/diagnostics10121027 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2075-4418/10/12/1027 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220208 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1032676426 |a Bendszus, Martin |m 1032676426:Bendszus, Martin |d 910000 |d 911100 |e 910000PB1032676426 |e 911100PB1032676426 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 106732626X |a Heiland, Sabine |m 106732626X:Heiland, Sabine |d 910000 |d 911100 |e 910000PH106732626X |e 911100PH106732626X |k 0/910000/ |k 1/910000/911100/ |p 8 | ||
| 998 | |g 1027093531 |a Kronlage, Moritz |m 1027093531:Kronlage, Moritz |d 910000 |d 911100 |d 50000 |e 910000PK1027093531 |e 911100PK1027093531 |e 50000PK1027093531 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 7 | ||
| 998 | |g 1153513471 |a Godel, Tim |m 1153513471:Godel, Tim |d 910000 |d 911100 |d 50000 |e 910000PG1153513471 |e 911100PG1153513471 |e 50000PG1153513471 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1788786580 |e 4052916158 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Godel, Tim","given":"Tim","role":"aut","family":"Godel"},{"given":"Katharina von","role":"aut","family":"Cossel","display":"Cossel, Katharina von"},{"family":"Friedrich","given":"Reinhard E.","role":"aut","display":"Friedrich, Reinhard E."},{"family":"Glatzel","role":"aut","given":"Markus","display":"Glatzel, Markus"},{"given":"Sima","role":"aut","family":"Canaan-Kühl","display":"Canaan-Kühl, Sima"},{"role":"aut","given":"Thomas","family":"Duning","display":"Duning, Thomas"},{"display":"Kronlage, Moritz","family":"Kronlage","role":"aut","given":"Moritz"},{"family":"Heiland","role":"aut","given":"Sabine","display":"Heiland, Sabine"},{"family":"Bendszus","given":"Martin","role":"aut","display":"Bendszus, Martin"},{"display":"Muschol, Nicole","family":"Muschol","given":"Nicole","role":"aut"},{"role":"aut","given":"Victor-Felix","family":"Mautner","display":"Mautner, Victor-Felix"}],"relHost":[{"part":{"volume":"10","year":"2020","issue":"12","extent":"11","text":"10(2020), 12, Artikel-ID 1027, Seite 1-11","pages":"1-11"},"title":[{"title":"Diagnostics","title_sort":"Diagnostics","subtitle":"open access journal"}],"id":{"issn":["2075-4418"],"eki":["718627814"],"zdb":["2662336-5"]},"note":["Gesehen am 28.05.2020"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2011 -"],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"2011-","publisherPlace":"Basel","publisher":"MDPI"}],"disp":"Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143TDiagnostics","recId":"718627814","physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedDisp":"30 November 2020","dateIssuedKey":"2020"}],"note":["Gesehen am 09.02.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title":"Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143T","title_sort":"Assessment of peripheral nervous system alterations in patients with the Fabry telated GLA-variant p.A143T"}],"physDesc":[{"extent":"11 S."}],"recId":"1788786580","name":{"displayForm":["Tim Godel, Katharina von Cossel, Reinhard E. Friedrich, Markus Glatzel, Sima Canaan-Kühl, Thomas Duning, Moritz Kronlage, Sabine Heiland, Martin Bendszus, Nicole Muschol and Victor-Felix Mautner"]},"id":{"eki":["1788786580"],"doi":["10.3390/diagnostics10121027"]}} | ||
| SRT | |a GODELTIMCOASSESSMENT3020 | ||