No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney transplantation
Natural killer (NK) cell function can be modulated by the killer cell immunoglobulin-like receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on target cells. KIR-ligand mismatching has recently been shown by van Bergen et al. (American Journal of Transplantation 2011...
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| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 February 2013
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| In: |
American journal of transplantation
Year: 2013, Volume: 13, Issue: 4, Pages: 1063-1068 |
| ISSN: | 1600-6143 |
| DOI: | 10.1111/ajt.12134 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/ajt.12134 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.12134 
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| Author Notes: | T.H. Tran, C. Unterrainer, G. Fiedler, B. Döhler, S. Scherer, A. Ruhenstroth, M. Adamek, D. Middleton and G. Opelz |
MARC
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| 520 | |a Natural killer (NK) cell function can be modulated by the killer cell immunoglobulin-like receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on target cells. KIR-ligand mismatching has recently been shown by van Bergen et al. (American Journal of Transplantation 2011; 11(9): 1959-1964) to be a significant risk factor for long-term graft loss in HLA-A, -B and -DR compatible kidney transplants. To verify this potentially important finding, we performed genotyping of 608 deceased-donor kidney graft recipients and their HLA-A, -B and -DR compatible donors for KIR and HLA, using samples and clinical data provided by the Collaborative Transplant Study. Graft survival of KIR-ligand-matched and -mismatched transplants was compared. We found no impact of KIR-ligand mismatching on 10-year graft survival in HLA-A, -B, -DR compatible kidney transplants. Further analysis did not reveal a significant effect of recipient activating/inhibitory KIR or KIR genotypes on graft survival. Our data do not support the concept that KIR-HLA matching might serve as a tool to improve long-term renal allograft survival. | ||
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