Concomitant chronic lymphocytic leukemia and multiple myeloma: proof of common clonal origin
We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL- and MM-cell were separated by preparative flourescence-activated cell sorting (FACS). DNA sequence analysis of the complementarity-determinining region III (CDR III) of the immunoglobulin...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2004
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| In: |
The Chinese-german journal of clinical oncology
Year: 2004, Jahrgang: 3, Heft: 2, Pages: 81-84 |
| ISSN: | 1613-9089 |
| DOI: | 10.1007/s10330-004-0264-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10330-004-0264-6
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| Verfasserangaben: | Christoph Sucker, Alwin Krämer, Marion Moos& Hartmut Goldschmidt |
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| 520 | |a We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL- and MM-cell were separated by preparative flourescence-activated cell sorting (FACS). DNA sequence analysis of the complementarity-determinining region III (CDR III) of the immunoglobulin heavy chain genes showed identical gene rearrangements in the CLL- and the MM-cell population. Our findings prove a common clonal tumor origin of both B-cell diseases in this patient. | ||
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