Allogeneic immunotherapy for relapsed multiple myeloma: role of matched unrelated donors
Existence of a graft-versus-myeloma effect has been well documented by responses to donor lymphocyte infusions and longterm survival after allogeneic bone marrow transplantation. The development of non-myeloablative conditioning regimens allows utilization of allogeneic effects in patients usually n...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2002
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| In: |
The Chinese-german journal of clinical oncology
Year: 2002, Jahrgang: 1, Heft: 2, Pages: 72-74 |
| ISSN: | 1613-9089 |
| DOI: | 10.1007/BF02851737 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF02851737
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| Verfasserangaben: | M. Görner, S. Höpfner, H. Goldschmidt & A.D. Ho |
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| 520 | |a Existence of a graft-versus-myeloma effect has been well documented by responses to donor lymphocyte infusions and longterm survival after allogeneic bone marrow transplantation. The development of non-myeloablative conditioning regimens allows utilization of allogeneic effects in patients usually not suitable for myeloablative allogeneic transplantation, such as older and heavily pretreated patients. In a small series of 11 patients with multiple myeloma relapsing after autologous transplantation, we show that conditioning with low-dose total body irradiation in combination with fludarabine allows stable engraftment after matched unrelated donor transplantation and is tolerated with acceptable transplant-related morbidity and mortality. With a short median follow-up of 225 days, disease control was achieved only for patients responding to conventional treatment prior to allografting. Future studies with longer follow-up have to define the role of non-myeloablative allogeneic transplantation from unrelated donors as consolidation for patients responding to salvage therapy. | ||
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