Thalidomide in newly diagnosed multiple myeloma: influence of thalidomide treatment on peripheral blood stem cell collection yield
In a phase III randomized, multicenter study, the German-speaking Myeloma-Multicenter Group (GMMG) and the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) group investigated the influence of thalidomide (Thal) on the outcome of peripheral blood stem cell (PBSC) collection in multiple myeloma...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 March 2007
|
| In: |
Leukemia
Year: 2007, Volume: 21, Issue: 6, Pages: 1294-1299 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/sj.leu.2404661 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.leu.2404661 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/2404661 
|
| Author Notes: | I. Breitkreutz, H.M. Lokhorst, M.S. Raab, B. van der Holt, F.W. Cremer, D. Herrmann, A. Glasmacher, I.G.H. Schmidt-Wolf, I.W. Blau, H. Martin, H. Salwender, A. Haenel, P. Sonneveld and H. Goldschmidt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1789464021 | ||
| 003 | DE-627 | ||
| 005 | 20220820125659.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220211s2007 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/sj.leu.2404661 |2 doi | |
| 035 | |a (DE-627)1789464021 | ||
| 035 | |a (DE-599)KXP1789464021 | ||
| 035 | |a (OCoLC)1341441644 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Breitkreutz, Iris |d 1970- |e VerfasserIn |0 (DE-588)124783309 |0 (DE-627)366051806 |0 (DE-576)186798725 |4 aut | |
| 245 | 1 | 0 | |a Thalidomide in newly diagnosed multiple myeloma |b influence of thalidomide treatment on peripheral blood stem cell collection yield |c I. Breitkreutz, H.M. Lokhorst, M.S. Raab, B. van der Holt, F.W. Cremer, D. Herrmann, A. Glasmacher, I.G.H. Schmidt-Wolf, I.W. Blau, H. Martin, H. Salwender, A. Haenel, P. Sonneveld and H. Goldschmidt |
| 264 | 1 | |c 22 March 2007 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.02.2022 | ||
| 520 | |a In a phase III randomized, multicenter study, the German-speaking Myeloma-Multicenter Group (GMMG) and the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) group investigated the influence of thalidomide (Thal) on the outcome of peripheral blood stem cell (PBSC) collection in multiple myeloma (MM) before peripheral autologous blood stem cell transplantation (ABSCT). We analyzed the data of 398 myeloma patients after induction with Thal, doxorubicin and dexamethasone (TAD) in comparison with vincristine, doxorubicin and dexamethasone (VAD) followed by mobilization with cyclophosphamide, doxorubicin, dexamethasone (CAD) and PBSC collection. Within both the study groups, patients treated with TAD showed to collect significantly fewer CD34+ cells compared with VAD (GMMG, TAD: median 9.8 × 106/kg; range 2.0-33.6; VAD: median 10.9 × 106/kg range 3.0-36.0; P=0.02) (HOVON, TAD: median 7.4 × 106/kg; range 2.0-33.0; VAD: median 9.4 × 106/kg; range 0.0-48.7; P=0.009). However, engraftment after peripheral autologous stem cell transplantation showed no difference between Thal and VAD groups. We conclude that Thal as a part of induction regimen is associated with better response rates (GMMG-HD3: CR/PR 79%, VAD: CR/PR 58%; HOVON-50: TAD: CR/PR 81%, VAD: CR/PR 61%), but significantly affects the yield of PBSC collection. Nevertheless, the number of total CD34+ cells collected was sufficient for double autologous transplantation in 82% of the Thal patients, with at least 2.5 × 106/kg CD34+ cells. | ||
| 650 | 4 | |a Cancer Research | |
| 650 | 4 | |a general | |
| 650 | 4 | |a Hematology | |
| 650 | 4 | |a Intensive / Critical Care Medicine | |
| 650 | 4 | |a Internal Medicine | |
| 650 | 4 | |a Medicine/Public Health | |
| 650 | 4 | |a Oncology | |
| 700 | 1 | |a Lokhorst, H. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Raab, Marc-Steffen |d 1973- |e VerfasserIn |0 (DE-588)124052460 |0 (DE-627)706520998 |0 (DE-576)293998027 |4 aut | |
| 700 | 1 | |a Holt, B. van der |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cremer, Friedrich Walter |d 1967- |e VerfasserIn |0 (DE-588)115550461 |0 (DE-627)691396221 |0 (DE-576)289943752 |4 aut | |
| 700 | 1 | |a Herrmann, Dieter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Glasmacher, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmidt-Wolf, I. G. H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blau, I. W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Martin, H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Salwender, H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haenel, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sonneveld, P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 21(2007), 6, Seite 1294-1299 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a Thalidomide in newly diagnosed multiple myeloma influence of thalidomide treatment on peripheral blood stem cell collection yield |
| 773 | 1 | 8 | |g volume:21 |g year:2007 |g number:6 |g pages:1294-1299 |g extent:6 |a Thalidomide in newly diagnosed multiple myeloma influence of thalidomide treatment on peripheral blood stem cell collection yield |
| 856 | 4 | 0 | |u https://doi.org/10.1038/sj.leu.2404661 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/2404661 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220211 | ||
| 993 | |a Article | ||
| 994 | |a 2007 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 14 |y j | ||
| 998 | |g 115550461 |a Cremer, Friedrich Walter |m 115550461:Cremer, Friedrich Walter |d 910000 |d 910100 |e 910000PC115550461 |e 910100PC115550461 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 124052460 |a Raab, Marc-Steffen |m 124052460:Raab, Marc-Steffen |d 910000 |d 910100 |e 910000PR124052460 |e 910100PR124052460 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 124783309 |a Breitkreutz, Iris |m 124783309:Breitkreutz, Iris |d 910000 |d 910100 |e 910000PB124783309 |e 910100PB124783309 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1789464021 |e 4056100187 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1038/sj.leu.2404661"],"eki":["1789464021"]},"recId":"1789464021","relHost":[{"disp":"Thalidomide in newly diagnosed multiple myeloma influence of thalidomide treatment on peripheral blood stem cell collection yieldLeukemia","physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"6","volume":"21","pages":"1294-1299","text":"21(2007), 6, Seite 1294-1299","year":"2007","issue":"6"},"language":["eng"],"recId":"32046699X","id":{"eki":["32046699X"],"issn":["1476-5551"],"zdb":["2008023-2"]},"note":["Gesehen am 15.03.04"],"title":[{"title_sort":"Leukemia","subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal","title":"Leukemia"}],"pubHistory":["Nachgewiesen 11.1997 -"],"origin":[{"dateIssuedKey":"1997","dateIssuedDisp":"1997-","publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group","publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"name":{"displayForm":["I. Breitkreutz, H.M. Lokhorst, M.S. Raab, B. van der Holt, F.W. Cremer, D. Herrmann, A. Glasmacher, I.G.H. Schmidt-Wolf, I.W. Blau, H. Martin, H. Salwender, A. Haenel, P. Sonneveld and H. Goldschmidt"]},"physDesc":[{"extent":"6 S."}],"language":["eng"],"title":[{"title":"Thalidomide in newly diagnosed multiple myeloma","subtitle":"influence of thalidomide treatment on peripheral blood stem cell collection yield","title_sort":"Thalidomide in newly diagnosed multiple myeloma"}],"person":[{"role":"aut","display":"Breitkreutz, Iris","given":"Iris","family":"Breitkreutz"},{"role":"aut","display":"Lokhorst, H. M.","family":"Lokhorst","given":"H. M."},{"role":"aut","display":"Raab, Marc-Steffen","given":"Marc-Steffen","family":"Raab"},{"role":"aut","family":"Holt","given":"B. van der","display":"Holt, B. van der"},{"role":"aut","family":"Cremer","given":"Friedrich Walter","display":"Cremer, Friedrich Walter"},{"role":"aut","display":"Herrmann, Dieter","given":"Dieter","family":"Herrmann"},{"role":"aut","given":"A.","family":"Glasmacher","display":"Glasmacher, A."},{"display":"Schmidt-Wolf, I. G. H.","given":"I. G. H.","family":"Schmidt-Wolf","role":"aut"},{"role":"aut","display":"Blau, I. W.","family":"Blau","given":"I. W."},{"role":"aut","family":"Martin","given":"H.","display":"Martin, H."},{"role":"aut","family":"Salwender","given":"H.","display":"Salwender, H."},{"role":"aut","family":"Haenel","given":"A.","display":"Haenel, A."},{"role":"aut","family":"Sonneveld","given":"P.","display":"Sonneveld, P."},{"given":"Hartmut","family":"Goldschmidt","display":"Goldschmidt, Hartmut","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"22 March 2007","dateIssuedKey":"2007"}],"note":["Gesehen am 11.02.2022"]} | ||
| SRT | |a BREITKREUTTHALIDOMID2220 | ||