Circulating miRNAs: cell-cell communication function?
Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species mi...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 June 2013
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| In: |
Frontiers in genetics
Year: 2013, Jahrgang: 4, Pages: 1-10 |
| ISSN: | 1664-8021 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fgene.2013.00119
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| Verfasserangaben: | A. Turchinovich, T.R. Samatov, A.G. Tonevitsky, and B. Burwinkel |
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| 520 | |a Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell-cell signaling function during various physiological and pathological processes. In this review, we discuss the state-of-the-art in the field of intercellular miRNA transport and highlight current theories regarding the origin and the biological function of extracellular miRNAs. | ||
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