On track to tackle dengue: History and future of NS4B ligands
A recent publication in Nature (Kaptein et al., 2021) reports a highly potent antiviral compound against dengue with promising efficacy in mice. Here, we track the history of this compound class, its pharmacology, and its chemistry, with insights into its potential as orally available drugs to preve...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 December 2021
|
| In: |
Cell host and microbe
Year: 2021, Jahrgang: 29, Heft: 12, Pages: 1735-1737 |
| ISSN: | 1934-6069 |
| DOI: | 10.1016/j.chom.2021.11.010 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.chom.2021.11.010 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1931312821005163 
|
| Verfasserangaben: | Mira A.M. Behnam, Christian D. Klein |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 178958437X | ||
| 003 | DE-627 | ||
| 005 | 20240415193329.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220215s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.chom.2021.11.010 |2 doi | |
| 035 | |a (DE-627)178958437X | ||
| 035 | |a (DE-599)KXP178958437X | ||
| 035 | |a (OCoLC)1341441641 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Behnam, Mira A. M. |e VerfasserIn |0 (DE-588)1060575957 |0 (DE-627)800333284 |0 (DE-576)416731252 |4 aut | |
| 245 | 1 | 0 | |a On track to tackle dengue |b History and future of NS4B ligands |c Mira A.M. Behnam, Christian D. Klein |
| 264 | 1 | |c 8 December 2021 | |
| 300 | |a 3 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.02.2022 | ||
| 520 | |a A recent publication in Nature (Kaptein et al., 2021) reports a highly potent antiviral compound against dengue with promising efficacy in mice. Here, we track the history of this compound class, its pharmacology, and its chemistry, with insights into its potential as orally available drugs to prevent and treat dengue. | ||
| 700 | 1 | |a Klein, Christian D. |e VerfasserIn |0 (DE-588)1060644894 |0 (DE-627)800410157 |0 (DE-576)416768717 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell host and microbe |d Amsterdam [u.a.] : Elsevier, 2007 |g 29(2021), 12, Seite 1735-1737 |h Online-Ressource |w (DE-627)527572993 |w (DE-600)2276339-9 |w (DE-576)264425944 |x 1934-6069 |7 nnas |a On track to tackle dengue History and future of NS4B ligands |
| 773 | 1 | 8 | |g volume:29 |g year:2021 |g number:12 |g pages:1735-1737 |g extent:3 |a On track to tackle dengue History and future of NS4B ligands |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.chom.2021.11.010 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1931312821005163 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220215 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1060644894 |a Klein, Christian D. |m 1060644894:Klein, Christian D. |d 160000 |d 160100 |e 160000PK1060644894 |e 160100PK1060644894 |k 0/160000/ |k 1/160000/160100/ |p 2 |y j | ||
| 999 | |a KXP-PPN178958437X |e 4059828653 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"178958437X","physDesc":[{"extent":"3 S."}],"title":[{"title_sort":"On track to tackle dengue","title":"On track to tackle dengue","subtitle":"History and future of NS4B ligands"}],"note":["Gesehen am 15.02.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"relHost":[{"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"2007","dateIssuedDisp":"2007-","publisher":"Elsevier"}],"pubHistory":["1.2007 -"],"id":{"zdb":["2276339-9"],"issn":["1934-6069"],"eki":["527572993"]},"part":{"text":"29(2021), 12, Seite 1735-1737","extent":"3","issue":"12","pages":"1735-1737","volume":"29","year":"2021"},"title":[{"title_sort":"Cell host and microbe","title":"Cell host and microbe"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 20.11.2020"],"recId":"527572993","physDesc":[{"extent":"Online-Ressource"}],"disp":"On track to tackle dengue History and future of NS4B ligandsCell host and microbe"}],"person":[{"display":"Behnam, Mira A. M.","given":"Mira A. M.","role":"aut","family":"Behnam"},{"display":"Klein, Christian D.","role":"aut","given":"Christian D.","family":"Klein"}],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"8 December 2021"}],"id":{"doi":["10.1016/j.chom.2021.11.010"],"eki":["178958437X"]},"name":{"displayForm":["Mira A.M. Behnam, Christian D. Klein"]}} | ||
| SRT | |a BEHNAMMIRAONTRACKTOT8202 | ||