Clinical significance of cyclooxygenase-2 (COX-2) in multiple myeloma
Several biological and clinical considerations suggest the involvement of cyclooxygenase-2 (COX-2), the key enzyme of prostaglandin (PG) synthesis, in the pathogenesis and progression of haematological malignancies. Despite the wealth of data concerning COX-2 expression, only limited information is...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[2006]
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| In: |
Swiss medical weekly
Year: 2006, Volume: 136, Issue: 25/26, Pages: 400-403 |
| ISSN: | 1424-3997 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://serval.unil.ch/resource/serval:BIB_F68233E85238.P001/REF
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| Author Notes: | Andreas Trojan, Marianne Tinguely, Sonia Vallet, Burkhardt Seifert, Bettina Jenni, Alfred Zippelius, Mathias Witzens-Harig, Gunhild Mechtersheimer, Anthony D. Ho, Hartmut Goldschmidt, Dirk Jäger, Mario Boccadoro, Marco Ladetto |
MARC
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| 245 | 1 | 0 | |a Clinical significance of cyclooxygenase-2 (COX-2) in multiple myeloma |c Andreas Trojan, Marianne Tinguely, Sonia Vallet, Burkhardt Seifert, Bettina Jenni, Alfred Zippelius, Mathias Witzens-Harig, Gunhild Mechtersheimer, Anthony D. Ho, Hartmut Goldschmidt, Dirk Jäger, Mario Boccadoro, Marco Ladetto |
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| 520 | |a Several biological and clinical considerations suggest the involvement of cyclooxygenase-2 (COX-2), the key enzyme of prostaglandin (PG) synthesis, in the pathogenesis and progression of haematological malignancies. Despite the wealth of data concerning COX-2 expression, only limited information is available on multiple myeloma (MM). Using standard immunohistochemistry we therefore evaluated COX-2 protein expression in samples from 57 patients with a primary diagnosis of MM. Time to progression and a variety of clinicopathological features were evaluated by the Kaplan-Meier method and the Cox regression model. In addition, COX-2 expression was evaluated by staining bone marrow from healthy donors and 11 patients with MGUS. Overall, 31 MM samples (54%) expressed COX-2. Positivity for COX-2 was unrelated to stage or clinical or molecular features of the disease. However, patients with COX-2 positive tumours experienced a significantly shorter time to progression (17 vs 30 months, p = 0.037). In summary, COX-2 is frequently expressed in MM and correlates with shorter progression-free survival. | ||
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| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Cyclooxygenase 2 | |
| 650 | 4 | |a Disease Progression | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Multiple Myeloma | |
| 650 | 4 | |a Proportional Hazards Models | |
| 650 | 4 | |a Survival Analysis | |
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