Prognostic factors for donor lymphocyte infusions following non-myeloablative allogeneic stem cell transplantation in multiple myeloma
In this retrospective study, we evaluated donor lymphocyte infusions given for relapsed (n=48) or persistent (n=15) myeloma following non-myeloablative allogeneic stem cell transplantation (Allo-SCT). Twenty-four of 63 patients (38.1%) responded: 12 patients (19.0%) with a partial response (PR) and...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
07 June 2006
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| In: |
Bone marrow transplantation
Year: 2006, Jahrgang: 37, Heft: 12, Pages: 1135-1141 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/sj.bmt.1705393 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.bmt.1705393 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/1705393 
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| Verfasserangaben: | N. W. C. J. van de Donk, N. Kröger, U. Hegenbart, P. Corradini, J. F. San Miguel, H. Goldschmidt, J. A. Perez-Simon, M. Zijlmans, R. A. Raymakers, V. Montefusco, F. A. Ayuk, M. H. J. van Oers, A. Nagler and L. F. Verdonck, H. M. Lokhorst |
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| 245 | 1 | 0 | |a Prognostic factors for donor lymphocyte infusions following non-myeloablative allogeneic stem cell transplantation in multiple myeloma |c N. W. C. J. van de Donk, N. Kröger, U. Hegenbart, P. Corradini, J. F. San Miguel, H. Goldschmidt, J. A. Perez-Simon, M. Zijlmans, R. A. Raymakers, V. Montefusco, F. A. Ayuk, M. H. J. van Oers, A. Nagler and L. F. Verdonck, H. M. Lokhorst |
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| 520 | |a In this retrospective study, we evaluated donor lymphocyte infusions given for relapsed (n=48) or persistent (n=15) myeloma following non-myeloablative allogeneic stem cell transplantation (Allo-SCT). Twenty-four of 63 patients (38.1%) responded: 12 patients (19.0%) with a partial response (PR) and 12 patients (19.0%) with a complete response (CR). Overall survival after donor lymphocyte infusions (DLI) was 23.6 months (1.0-50.7+). Median overall survival for non-responding patients was 23.6 months and has not been reached for the patients responding to DLI. In responders, progression-free survival after DLI was 27.8 months (1.2-46.2+). Patients with a PR had a median progression-free survival of 7.0 months, whereas patients with a CR to DLI had a median progression-free survival of 27.8 months. Major toxicities were acute graft-versus-host disease (GVHD) (38.1%) and chronic GVHD (42.9%). Seven patients (11.1%) died from treatment-related mortality. The only significant prognostic factors for response to DLI were the occurrence of acute and chronic GVHD. There was a trend towards significance for time between transplantation and DLI, and response. Donor lymphocyte infusion following non-myeloablative Allo-SCT is a valuable strategy for relapsed or persistent disease. | ||
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