Cover Image

Pannexins in ischemia-induced neurodegeneration

Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed...

Full description

Saved in:
Bibliographic Details
Main Authors: Bargiotas, Panagiotis (Author) , Krenz, Antje (Author) , Hormuzdi, Sheriar G. (Author) , Ridder, Dirk A. (Author) , Herb, Anne (Author) , Barakat, Waleed (Author) , Penuela, Silvia (Author) , Engelhardt, Jakob von (Author) , Monyer, Hannah (Author) , Schwaninger, Markus (Author)
Format: Article (Journal)
Language:English
Published: December 6, 2011
In: Proceedings of the National Academy of Sciences of the United States of America
Year: 2011, Volume: 108, Issue: 51, Pages: 20772-20777
ISSN:0027-8424
DOI:10.1073/pnas.1018262108
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.1018262108
Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/108/51/20772
Get full text
Author Notes:Panagiotis Bargiotas, Antje Krenz, Sheriar G. Hormuzdi, Dirk A. Ridder, Anne Herb, Waleed Barakat, Silvia Penuela, Jakob von Engelhardt, Hannah Monyer, and Markus Schwaninger

MARC

LEADER 00000caa a2200000 c 4500
001 1789959713
003 DE-627
005 20220820132230.0
007 cr uuu---uuuuu
008 220217s2011 xx |||||o 00| ||eng c
024 7 |a 10.1073/pnas.1018262108  |2 doi 
035 |a (DE-627)1789959713 
035 |a (DE-599)KXP1789959713 
035 |a (OCoLC)1341441870 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Bargiotas, Panagiotis  |d 1981-  |e VerfasserIn  |0 (DE-588)1028373899  |0 (DE-627)730621898  |0 (DE-576)375908234  |4 aut 
245 1 0 |a Pannexins in ischemia-induced neurodegeneration  |c Panagiotis Bargiotas, Antje Krenz, Sheriar G. Hormuzdi, Dirk A. Ridder, Anne Herb, Waleed Barakat, Silvia Penuela, Jakob von Engelhardt, Hannah Monyer, and Markus Schwaninger 
264 1 |c December 6, 2011 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 17.02.2022 
520 |a Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed experiments in Px1−/−, Px2−/−, and Px1−/−Px2−/− knockout mice. IL-1β release, channel function in astrocytes, and cortical spreading depolarization were not altered in Px1−/−Px2−/− mice, indicating that, in contrast to previous concepts, these processes occur normally in the absence of pannexin channels. However, ischemia-induced dye release from cortical neurons was lower, indicating that channel function in Px1−/−Px2−/− neurons was impaired. Furthermore, Px1−/−Px2−/− mice had a better functional outcome and smaller infarcts than wild-type mice when subjected to ischemic stroke. In conclusion, our data demonstrate that Px1 and Px2 underlie channel function in neurons and contribute to ischemic brain damage. 
650 4 |a ATP release 
650 4 |a gap junctions 
650 4 |a macrophage 
650 4 |a metabolic inhibition 
650 4 |a middle cerebral artery occlusion 
700 1 |a Krenz, Antje  |e VerfasserIn  |4 aut 
700 1 |a Hormuzdi, Sheriar G.  |e VerfasserIn  |4 aut 
700 1 |a Ridder, Dirk A.  |e VerfasserIn  |4 aut 
700 1 |a Herb, Anne  |e VerfasserIn  |0 (DE-588)1070544396  |0 (DE-627)824003985  |0 (DE-576)430208383  |4 aut 
700 1 |a Barakat, Waleed  |e VerfasserIn  |4 aut 
700 1 |a Penuela, Silvia  |e VerfasserIn  |4 aut 
700 1 |a Engelhardt, Jakob von  |d 1972-  |e VerfasserIn  |0 (DE-588)123098904  |0 (DE-627)706160320  |0 (DE-576)293555028  |4 aut 
700 1 |a Monyer, Hannah  |d 1957-  |e VerfasserIn  |0 (DE-588)1012792374  |0 (DE-627)662740416  |0 (DE-576)345945514  |4 aut 
700 1 |a Schwaninger, Markus  |e VerfasserIn  |0 (DE-588)1028374909  |0 (DE-627)730623939  |0 (DE-576)375910174  |4 aut 
773 0 8 |i Enthalten in  |a National Academy of Sciences (Washington, DC)  |t Proceedings of the National Academy of Sciences of the United States of America  |d Washington, DC : NAS, 1877  |g 108(2011), 51, Seite 20772-20777  |w (DE-627)129505269  |w (DE-600)209104-5  |w (DE-576)014909189  |x 0027-8424  |7 nnas 
773 1 8 |g volume:108  |g year:2011  |g number:51  |g pages:20772-20777  |g extent:6  |a Pannexins in ischemia-induced neurodegeneration 
856 4 0 |u https://doi.org/10.1073/pnas.1018262108  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.pnas.org/content/108/51/20772  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220217 
993 |a Article 
994 |a 2011 
998 |g 1028374909  |a Schwaninger, Markus  |m 1028374909:Schwaninger, Markus  |d 50000  |e 50000PS1028374909  |k 0/50000/  |p 10  |y j 
998 |g 1012792374  |a Monyer, Hannah  |m 1012792374:Monyer, Hannah  |d 910000  |d 911100  |e 910000PM1012792374  |e 911100PM1012792374  |k 0/910000/  |k 1/910000/911100/  |p 9 
998 |g 123098904  |a Engelhardt, Jakob von  |m 123098904:Engelhardt, Jakob von  |d 50000  |e 50000PE123098904  |k 0/50000/  |p 8 
998 |g 1070544396  |a Herb, Anne  |m 1070544396:Herb, Anne  |d 910000  |d 911100  |e 910000PH1070544396  |e 911100PH1070544396  |k 0/910000/  |k 1/910000/911100/  |p 5 
998 |g 1028373899  |a Bargiotas, Panagiotis  |m 1028373899:Bargiotas, Panagiotis  |d 50000  |e 50000PB1028373899  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1789959713  |e 4061059564 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1789959713","note":["Gesehen am 17.02.2022"],"relHost":[{"id":{"eki":["129505269"],"zdb":["209104-5"],"issn":["0027-8424"]},"titleAlt":[{"title":"PNAS"}],"corporate":[{"roleDisplay":"VerfasserIn","role":"aut","display":"National Academy of Sciences"}],"pubHistory":["1.1877/95; Vol. 27.1941,5; [N.S.] 1.1915 - 111.2014"],"type":{"bibl":"periodical"},"recId":"129505269","part":{"volume":"108","issue":"51","text":"108(2011), 51, Seite 20772-20777","pages":"20772-20777","year":"2011","extent":"6"},"note":["Zusatz ab 96.1999","Fortgesetzt als Online-Ausgabe","Repr.: New York, NY : Johnson","Inhaltl. Gliederung 77.1980 - 81.1984 in: Physical sciences; Biological sciences; bei durchgehender Nr.- u. Seitenzählung"],"physDesc":[{"noteFormat":"26 cm"}],"origin":[{"dateIssuedKey":"1877","publisherPlace":"Washington, DC ; Baltimore, Md. [u.a.]","dateIssuedDisp":"1877-2014","publisher":"NAS ; Mack Pr. Comp."}],"language":["eng"],"disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","title":[{"title_sort":"Proceedings of the National Academy of Sciences of the United States of America","title":"Proceedings of the National Academy of Sciences of the United States of America","subtitle":"PNAS"}]}],"name":{"displayForm":["Panagiotis Bargiotas, Antje Krenz, Sheriar G. Hormuzdi, Dirk A. Ridder, Anne Herb, Waleed Barakat, Silvia Penuela, Jakob von Engelhardt, Hannah Monyer, and Markus Schwaninger"]},"id":{"eki":["1789959713"],"doi":["10.1073/pnas.1018262108"]},"origin":[{"dateIssuedDisp":"December 6, 2011","dateIssuedKey":"2011"}],"physDesc":[{"extent":"6 S."}],"language":["eng"],"person":[{"family":"Bargiotas","given":"Panagiotis","roleDisplay":"VerfasserIn","role":"aut","display":"Bargiotas, Panagiotis"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Antje","display":"Krenz, Antje","family":"Krenz"},{"family":"Hormuzdi","roleDisplay":"VerfasserIn","role":"aut","given":"Sheriar G.","display":"Hormuzdi, Sheriar G."},{"family":"Ridder","role":"aut","roleDisplay":"VerfasserIn","given":"Dirk A.","display":"Ridder, Dirk A."},{"display":"Herb, Anne","given":"Anne","role":"aut","roleDisplay":"VerfasserIn","family":"Herb"},{"family":"Barakat","display":"Barakat, Waleed","role":"aut","roleDisplay":"VerfasserIn","given":"Waleed"},{"family":"Penuela","display":"Penuela, Silvia","roleDisplay":"VerfasserIn","role":"aut","given":"Silvia"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Jakob von","display":"Engelhardt, Jakob von","family":"Engelhardt"},{"family":"Monyer","roleDisplay":"VerfasserIn","role":"aut","given":"Hannah","display":"Monyer, Hannah"},{"family":"Schwaninger","given":"Markus","role":"aut","roleDisplay":"VerfasserIn","display":"Schwaninger, Markus"}],"title":[{"title":"Pannexins in ischemia-induced neurodegeneration","title_sort":"Pannexins in ischemia-induced neurodegeneration"}]} 
SRT |a BARGIOTASPPANNEXINSI6201 

Similar Items