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Lentiviral vector integration profiles differ in rodent postmitotic tissues

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Lentiviral vectors with self-inactivating (SIN) long terminal repeats (LTRs) are promising for safe and sustained transgene expression in dividing as well as quiescent cells. As genome organization and transcription substantially differs between actively dividing and postmitotic cells in vivo, we hy...

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Main Authors: Bartholomä, Cynthia C. (Author) , Arens, Anne (Author) , Balaggan, Kamaljit S. (Author) , Yáñez-Muñoz, Rafael J. (Author) , Montini, Eugenio (Author) , Howe, Steven J. (Author) , Paruzynski, Anna (Author) , Korn, Bernhard (Author) , Appelt, Jens-Uwe (Author) , MacNeil, Angus (Author) , Cesana, Daniela (Author) , Abel, Ulrich (Author) , Glimm, Hanno (Author) , Naldini, Luigi (Author) , Ali, Robin R. (Author) , Thrasher, Adrian J. (Author) , Kalle, Christof von (Author) , Schmidt, Manfred (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Molecular therapy
Year: 2011, Volume: 19, Issue: 4, Pages: 703-710
ISSN:1525-0024
DOI:10.1038/mt.2011.19
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/mt.2011.19
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1525001616304269
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Author Notes:Cynthia C Bartholomae, Anne Arens, Kamaljit S Balaggan, Rafael J Yáñez-Muñoz, Eugenio Montini, Steven J Howe, Anna Paruzynski, Bernhard Korn, Jens Uwe Appelt, Angus MacNeil, Daniela Cesana, Ulrich Abel, Hanno Glimm, Luigi Naldini, Robin R Ali, Adrian J Thrasher, Christof von Kalle and Manfred Schmidt
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Lentiviral vector integration profiles differ in rodent postmitotic tissues by Bartholomä, Cynthia C. (Author) , Arens, Anne (Author) , Balaggan, Kamaljit S. (Author) , Yáñez-Muñoz, Rafael J. (Author) , Montini, Eugenio (Author) , Howe, Steven J. (Author) , Paruzynski, Anna (Author) , Korn, Bernhard (Author) , Appelt, Jens-Uwe (Author) , MacNeil, Angus (Author) , Cesana, Daniela (Author) , Abel, Ulrich (Author) , Glimm, Hanno (Author) , Naldini, Luigi (Author) , Ali, Robin R. (Author) , Thrasher, Adrian J. (Author) , Kalle, Christof von (Author) , Schmidt, Manfred (Author) ,


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