Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism
Background - An increased risk for venous thromboembolism (VTE), comprising pulmonary embolism (PE) and deep venous thrombosis, has been reported in psoriasis patients. The impact of psoriasis on prognosis of VTE patients is widely unknown. - Methods - Hospitalized PE patients were stratified for ps...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 September 2021
|
| In: |
International journal of cardiology
Year: 2021, Jahrgang: 343, Pages: 114-121 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2021.08.042 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2021.08.042 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527321013085 
|
| Verfasserangaben: | Karsten Keller, Lukas Hobohm, Mir A. Ostad, Susanne Karbach, Christine Espinola-Klein, Thomas Münzel, Joel M. Gelfand, Stavros V. Konstantinides, Kerstin Steinbrink, Tommaso Gori |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1793749108 | ||
| 003 | DE-627 | ||
| 005 | 20240415193342.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220223s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijcard.2021.08.042 |2 doi | |
| 035 | |a (DE-627)1793749108 | ||
| 035 | |a (DE-599)KXP1793749108 | ||
| 035 | |a (OCoLC)1341442311 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Keller, Karsten |d 1974- |e VerfasserIn |0 (DE-588)133143589 |0 (DE-627)537504206 |0 (DE-576)299652041 |4 aut | |
| 245 | 1 | 0 | |a Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism |c Karsten Keller, Lukas Hobohm, Mir A. Ostad, Susanne Karbach, Christine Espinola-Klein, Thomas Münzel, Joel M. Gelfand, Stavros V. Konstantinides, Kerstin Steinbrink, Tommaso Gori |
| 264 | 1 | |c 1 September 2021 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.02.2022 | ||
| 520 | |a Background - An increased risk for venous thromboembolism (VTE), comprising pulmonary embolism (PE) and deep venous thrombosis, has been reported in psoriasis patients. The impact of psoriasis on prognosis of VTE patients is widely unknown. - Methods - Hospitalized PE patients were stratified for psoriasis and the impact of psoriasis on outcome was investigated in the German nationwide inpatient sample of the years 2005-2017. - Results - Overall, 1,076,384 hospitalizations of PE patients (53.7% females, median age 72.0 [60.0-80.0] years) were recorded in Germany 2005-2017. Among these, 3145 patients had psoriasis (0.3%). Psoriatic PE patients were younger (68.0 [57.0-76.0] vs. 72.0 [60.0-80.0] years,P < 0.001) and more often male (64.1% vs. 46.3%,P < 0.001). The prevalence of VTE risk factors, traditional cardiovascular risk factors and cardiovascular comorbidities was higher in psoriatic than in non-psoriatic individuals. Psoriatic PE patients showed a lower in-hospital case-fatality rate (11.1% vs. 16.0%,P < 0.001), confirmed by logistic regressions showing an independent association of psoriasis with reduced case-fatality rate (OR 0.73 [95%CI 0.65-0.82],P < 0.001), despite higher prevalence of pneumonia (24.8% vs. 23.2%,P = 0.029). Psoriasis was an independent predictor for gastro-intestinal bleeding (OR 1.35 [95%CI 1.04-1.75],P = 0.023) and transfusion of blood constituents (OR 1.23 [95%CI 1.11-1.36],P < 0.001). - Conclusions - PE patients with psoriasis were hospitalized in median four years earlier than those without. Although psoriasis was associated with an unfavorable cardiovascular-risk and VTE-risk profile in PE patients, our data demonstrate a lower in-hospital mortality in psoriatic PE, which might be mainly driven by younger age. Our findings may improve the clinical management of these patients and contribute evidence for relevant systemic manifestation of psoriasis. - Translational perspective - An increased risk for venous thromboembolism (VTE), comprising pulmonary embolism (PE) and deep venous thrombosis, has been reported in psoriasis patients, but the impact of psoriasis on prognosis of VTE patients is widely unknown. PE patients with psoriasis were younger and psoriasis was associated with an unfavorable cardiovascular-risk and VTE-risk profile. In-hospital mortality was lower in psoriatic PE patients, which might be mainly driven by younger age. Our findings improve the clinical management of PE patients and contribute evidence for relevant systemic manifestation of psoriasis. - One sentence summary - Psoriasis with chronic inflammation promotes PE development, is associated with an unfavorable cardiovascular and VTE-risk profile, but lower in-hospital mortality. | ||
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Psoriasis | |
| 650 | 4 | |a Pulmonary embolism | |
| 650 | 4 | |a Venous thromboembolism | |
| 700 | 1 | |a Hobohm, Lukas |d 1987- |e VerfasserIn |0 (DE-588)1190312093 |0 (DE-627)1669008010 |4 aut | |
| 700 | 1 | |a Ostad, Mir A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karbach, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Espinola-Klein, Christine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Münzel, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gelfand, Joel M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Konstantinides, Stavros V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steinbrink, Kerstin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gori, Tommaso |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cardiology |d Amsterdam [u.a.] : Elsevier Science, 1981 |g 343(2021), Seite 114-121 |h Online-Ressource |w (DE-627)306659581 |w (DE-600)1500478-8 |w (DE-576)081986270 |x 1874-1754 |7 nnas |a Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism |
| 773 | 1 | 8 | |g volume:343 |g year:2021 |g pages:114-121 |g extent:8 |a Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijcard.2021.08.042 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0167527321013085 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220223 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 133143589 |a Keller, Karsten |m 133143589:Keller, Karsten |d 910000 |d 910100 |e 910000PK133143589 |e 910100PK133143589 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1793749108 |e 4071789298 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1793749108","name":{"displayForm":["Karsten Keller, Lukas Hobohm, Mir A. Ostad, Susanne Karbach, Christine Espinola-Klein, Thomas Münzel, Joel M. Gelfand, Stavros V. Konstantinides, Kerstin Steinbrink, Tommaso Gori"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"id":{"issn":["1874-1754"],"eki":["306659581"],"zdb":["1500478-8"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1981 -"],"recId":"306659581","note":["Gesehen am 13.02.20","Ungezählte Beil.: Supplement"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1981","dateIssuedDisp":"1981-","publisherPlace":"Amsterdam [u.a.]"}],"title":[{"title":"International journal of cardiology","title_sort":"International journal of cardiology"}],"part":{"volume":"343","extent":"8","pages":"114-121","text":"343(2021), Seite 114-121","year":"2021"},"language":["eng"],"disp":"Psoriasis and its impact on the clinical outcome of patients with pulmonary embolismInternational journal of cardiology"}],"id":{"eki":["1793749108"],"doi":["10.1016/j.ijcard.2021.08.042"]},"person":[{"role":"aut","given":"Karsten","display":"Keller, Karsten","family":"Keller"},{"family":"Hobohm","display":"Hobohm, Lukas","role":"aut","given":"Lukas"},{"family":"Ostad","display":"Ostad, Mir A.","role":"aut","given":"Mir A."},{"given":"Susanne","role":"aut","family":"Karbach","display":"Karbach, Susanne"},{"display":"Espinola-Klein, Christine","family":"Espinola-Klein","role":"aut","given":"Christine"},{"display":"Münzel, Thomas","family":"Münzel","role":"aut","given":"Thomas"},{"display":"Gelfand, Joel M.","family":"Gelfand","role":"aut","given":"Joel M."},{"display":"Konstantinides, Stavros V.","family":"Konstantinides","given":"Stavros V.","role":"aut"},{"given":"Kerstin","role":"aut","display":"Steinbrink, Kerstin","family":"Steinbrink"},{"given":"Tommaso","role":"aut","family":"Gori","display":"Gori, Tommaso"}],"language":["eng"],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"1 September 2021"}],"note":["Gesehen am 23.02.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism","title":"Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism"}]} | ||
| SRT | |a KELLERKARSPSORIASISA1202 | ||