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Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a decreased output of naive T cells that may contribute to the...

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Main Authors: Van Nuffel, Anouk (Author) , Ariën, Kevin K. (Author) , Stove, Veronique (Author) , Schindler, Michael (Author) , O’Neill, Eduardo (Author) , Schmökel, Jan (Author) , Van de Walle, Inge (Author) , Naessens, Evelien (Author) , Vanderstraeten, Hanne (Author) , Van Landeghem, Kathleen (Author) , Taghon, Tom (Author) , Pulkkinen, Kati (Author) , Saksela, Kalle (Author) , Garcia, J. Victor (Author) , Fackler, Oliver Till (Author) , Kirchhoff, Frank (Author) , Verhasselt, Bruno (Author)
Format: Article (Journal)
Language:English
Published: 15 November 2013
In: Retrovirology
Year: 2013, Volume: 10, Pages: 1-13
ISSN:1742-4690
DOI:10.1186/1742-4690-10-137
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-4690-10-137
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Author Notes:Anouk Van Nuffel, Kevin K. Ariën, Veronique Stove, Michael Schindler, Eduardo O’Neill, Jan Schmökel, Inge Van de Walle, Evelien Naessens, Hanne Vanderstraeten, Kathleen Van Landeghem, Tom Taghon, Kati Pulkkinen, Kalle Saksela, J. Victor Garcia, Oliver T. Fackler, Frank Kirchhoff and Bruno Verhasselt

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