Targeted intraoperative radiotherapy (targit) yields very low recurrence rates when given as a boost
Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach. Methods and Materials: We treated 302 cancers in 301 unselected pati...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 November 2006
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| In: |
International journal of radiation oncology, biology, physics
Year: 2006, Jahrgang: 66, Heft: 5, Pages: 1335-1338 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2006.07.1378 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2006.07.1378
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| Verfasserangaben: | Jayant S. Vaidya, Michael Baum, Jeffrey S. Tobias, Samuele Massarut, Frederik Wenz, Olive Murphy, Basil Hilaris, Joan Houghton, Christobel Saunders, Tammy Corica, Mario Roncadin, Uta Kraus-Tiefenbacher, Frank Melchaert, Mohammed Keshtgar, Richard Sainsbury, Michael Douek, Elly Harrison, Alastair Thompson, David Joseph |
MARC
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| 245 | 1 | 0 | |a Targeted intraoperative radiotherapy (targit) yields very low recurrence rates when given as a boost |c Jayant S. Vaidya, Michael Baum, Jeffrey S. Tobias, Samuele Massarut, Frederik Wenz, Olive Murphy, Basil Hilaris, Joan Houghton, Christobel Saunders, Tammy Corica, Mario Roncadin, Uta Kraus-Tiefenbacher, Frank Melchaert, Mohammed Keshtgar, Richard Sainsbury, Michael Douek, Elly Harrison, Alastair Thompson, David Joseph |
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| 520 | |a Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach. Methods and Materials: We treated 302 cancers in 301 unselected patients. This was not a low-risk group. One-third of patients (98/301) were younger than 51 years of age. More than half of the tumors (172, 57%) were between 1 cm and 2 cm, and one-fifth (62, 21%) were > 2 cm; 29% (86) had a Grade 3 tumor and, in 29% (87), axillary lymph nodes contained metastasis. After primary surgery, 20 Gy was delivered intraoperatively to the surface of the tumor bed, followed by external-beam radiotherapy (EBRT), but excluding the usual boost. Results: The treatment was well tolerated. The follow-up ranged from 3 to 80 months (164 and 90 patients completed 2 and 3 years follow-up, respectively). Four patients (1.3%) had local recurrence. The Kaplan-Meier estimate of local recurrence is 2.6% (SE = 1.7) at 5 years. This compares favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study, in which only 8.1% patients were node-positive, as opposed to 29% in our series. Conclusion: Targeted intraoperative radiotherapy combined with EBRT results in a low local recurrence rate. This could be attributed to both accurate targeting and timeliness of the treatment. These data support the need for a randomized trial to test whether the TARGIT boost is superior to conventional external boost, especially in high-risk women. (c) 2006 Elsevier Inc. | ||
| 650 | 4 | |a boost | |
| 650 | 4 | |a brachytherapy | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a breast-conserving surgery | |
| 650 | 4 | |a early breast-cancer | |
| 650 | 4 | |a radiation | |
| 650 | 4 | |a recurrence rate | |
| 650 | 4 | |a targeted intraoperative radiotherapy (TARGIT) | |
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| 700 | 1 | |a Tobias, Jeffrey S. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Thompson, Alastair |e VerfasserIn |4 aut | |
| 700 | 1 | |a Joseph, David |e VerfasserIn |4 aut | |
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