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Targeted intraoperative radiotherapy (targit) yields very low recurrence rates when given as a boost

Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach. Methods and Materials: We treated 302 cancers in 301 unselected pati...

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Hauptverfasser: Vaidya, Jayant S. (VerfasserIn) , Baum, Michael (VerfasserIn) , Tobias, Jeffrey S. (VerfasserIn) , Massarut, Samuele (VerfasserIn) , Wenz, Frederik (VerfasserIn) , Murphy, Olive (VerfasserIn) , Hilaris, Basil (VerfasserIn) , Houghton, Joan (VerfasserIn) , Saunders, Christobel (VerfasserIn) , Corica, Tammy (VerfasserIn) , Roncadin, Mario (VerfasserIn) , Kraus-Tiefenbacher, Uta (VerfasserIn) , Melchaert, Frank (VerfasserIn) , Keshtgar, Mohammed (VerfasserIn) , Sainsbury, Richard (VerfasserIn) , Douek, Michael (VerfasserIn) , Harrison, Elly (VerfasserIn) , Thompson, Alastair (VerfasserIn) , Joseph, David (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2 November 2006
In: International journal of radiation oncology, biology, physics
Year: 2006, Jahrgang: 66, Heft: 5, Pages: 1335-1338
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2006.07.1378
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2006.07.1378
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Verfasserangaben:Jayant S. Vaidya, Michael Baum, Jeffrey S. Tobias, Samuele Massarut, Frederik Wenz, Olive Murphy, Basil Hilaris, Joan Houghton, Christobel Saunders, Tammy Corica, Mario Roncadin, Uta Kraus-Tiefenbacher, Frank Melchaert, Mohammed Keshtgar, Richard Sainsbury, Michael Douek, Elly Harrison, Alastair Thompson, David Joseph
Beschreibung
Zusammenfassung:Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach. Methods and Materials: We treated 302 cancers in 301 unselected patients. This was not a low-risk group. One-third of patients (98/301) were younger than 51 years of age. More than half of the tumors (172, 57%) were between 1 cm and 2 cm, and one-fifth (62, 21%) were > 2 cm; 29% (86) had a Grade 3 tumor and, in 29% (87), axillary lymph nodes contained metastasis. After primary surgery, 20 Gy was delivered intraoperatively to the surface of the tumor bed, followed by external-beam radiotherapy (EBRT), but excluding the usual boost. Results: The treatment was well tolerated. The follow-up ranged from 3 to 80 months (164 and 90 patients completed 2 and 3 years follow-up, respectively). Four patients (1.3%) had local recurrence. The Kaplan-Meier estimate of local recurrence is 2.6% (SE = 1.7) at 5 years. This compares favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study, in which only 8.1% patients were node-positive, as opposed to 29% in our series. Conclusion: Targeted intraoperative radiotherapy combined with EBRT results in a low local recurrence rate. This could be attributed to both accurate targeting and timeliness of the treatment. These data support the need for a randomized trial to test whether the TARGIT boost is superior to conventional external boost, especially in high-risk women. (c) 2006 Elsevier Inc.
Beschreibung:Gesehen am 24.02.2022
Beschreibung:Online Resource
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2006.07.1378

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