Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma: a comparative study with histology and clinical markers
Purpose To examine whether parameters of dynamic, contrast-enhanced MRI (DCE MRI) reflect the degree of infiltration and vessel density in corresponding bone marrow biopsy specimens. Materials and Methods The pelvis of 24 patients with multiple myeloma (MM) was examined using contrast-enhanced DCE M...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 June 2005
|
| In: |
Journal of magnetic resonance imaging
Year: 2005, Jahrgang: 22, Heft: 1, Pages: 154-162 |
| ISSN: | 1522-2586 |
| DOI: | 10.1002/jmri.20349 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jmri.20349 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.20349 
|
| Verfasserangaben: | Sílvia Nosàs-Garcia, Thomas Moehler, Klaus Wasser, Fabian Kiessling, Reiner Bartl, Ivan Zuna, Jens Hillengass, Hartmut Goldschmidt, Hans-Ulrich Kauczor, and Stefan Delorme |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1793894132 | ||
| 003 | DE-627 | ||
| 005 | 20230427030938.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220225s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jmri.20349 |2 doi | |
| 035 | |a (DE-627)1793894132 | ||
| 035 | |a (DE-599)KXP1793894132 | ||
| 035 | |a (OCoLC)1341445465 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Nosàs-Garcia, Sílvia |d 1977- |e VerfasserIn |0 (DE-588)128817372 |0 (DE-627)381568466 |0 (DE-576)297347683 |4 aut | |
| 245 | 1 | 0 | |a Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma |b a comparative study with histology and clinical markers |c Sílvia Nosàs-Garcia, Thomas Moehler, Klaus Wasser, Fabian Kiessling, Reiner Bartl, Ivan Zuna, Jens Hillengass, Hartmut Goldschmidt, Hans-Ulrich Kauczor, and Stefan Delorme |
| 264 | 1 | |c 21 June 2005 | |
| 300 | |b Illustrationen | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.02.2022 | ||
| 520 | |a Purpose To examine whether parameters of dynamic, contrast-enhanced MRI (DCE MRI) reflect the degree of infiltration and vessel density in corresponding bone marrow biopsy specimens. Materials and Methods The pelvis of 24 patients with multiple myeloma (MM) was examined using contrast-enhanced DCE MRI. Biopsy was obtained from the spina iliaca posterior superior. Using a two-compartment model (assuming one intravascular and one interstitial compartment), the parameters amplitude (A, the maximum, relative signal increase over baseline) and the exchange rate constant (kep, describing the redistribution of contrast agent from the interstitial into the intravascular compartment) in the biopsied region were calculated and compared with the histological and clinical data. Results DCE MRI parameters were significantly higher in lesions with marked infiltration than with mild or no infiltration (P < 0.05). The amplitude normalized to that in the iliac artery (An), but not kep, was higher in lesions with high vessel-density at histology (P = 0.01). Higher kep levels were found in presence of increased serum immunoglobulins. Conclusion Increased contrast uptake in the bone marrow of MM patients indicates at least moderate tumor involvement. Furthermore, the contrast enhancement correlates with vessel-density and serum markers of disease activity. J. Magn. Reson. Imaging 2005;22:154-162. © 2005 Wiley-Liss, Inc. | ||
| 650 | 4 | |a angiogenesis | |
| 650 | 4 | |a dynamic MRI | |
| 650 | 4 | |a infiltration | |
| 650 | 4 | |a multiple myeloma | |
| 650 | 4 | |a vessel density | |
| 700 | 1 | |a Möhler, Thomas |e VerfasserIn |0 (DE-588)1014877261 |0 (DE-627)705298051 |0 (DE-576)34979572X |4 aut | |
| 700 | 1 | |a Wasser, Klaus |d 1970- |e VerfasserIn |0 (DE-588)122276167 |0 (DE-627)705843483 |0 (DE-576)293190143 |4 aut | |
| 700 | 1 | |a Kießling, Fabian |d 1972- |e VerfasserIn |0 (DE-588)12274943X |0 (DE-627)706027485 |0 (DE-576)183627164 |4 aut | |
| 700 | 1 | |a Bartl, Reiner |d 1944- |e VerfasserIn |0 (DE-588)106851322 |0 (DE-627)504904019 |0 (DE-576)166927384 |4 aut | |
| 700 | 1 | |a Zuna, Ivan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hillengaß, Jens |d 1974- |e VerfasserIn |0 (DE-588)124918549 |0 (DE-627)368073823 |0 (DE-576)294568298 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Kauczor, Hans-Ulrich |d 1962- |e VerfasserIn |0 (DE-588)139267123 |0 (DE-627)70327113X |0 (DE-576)310955327 |4 aut | |
| 700 | 1 | |a Delorme, Stefan |e VerfasserIn |0 (DE-588)105842808X |0 (DE-627)796879761 |0 (DE-576)179470140 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of magnetic resonance imaging |d New York, NY : Wiley-Liss, 1991 |g 22(2005), 1 vom: Juni, Seite 154-162 |h Online-Ressource |w (DE-627)306360039 |w (DE-600)1497154-9 |w (DE-576)114617252 |x 1522-2586 |7 nnas |a Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma a comparative study with histology and clinical markers |
| 773 | 1 | 8 | |g volume:22 |g year:2005 |g number:1 |g month:06 |g pages:154-162 |g extent:7 |a Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma a comparative study with histology and clinical markers |
| 856 | 4 | 0 | |u https://doi.org/10.1002/jmri.20349 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.20349 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220225 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 8 | ||
| 998 | |g 124918549 |a Hillengaß, Jens |m 124918549:Hillengaß, Jens |d 910000 |d 910100 |e 910000PH124918549 |e 910100PH124918549 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 1014877261 |a Möhler, Thomas |m 1014877261:Möhler, Thomas |d 910000 |d 910100 |e 910000PM1014877261 |e 910100PM1014877261 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 999 | |a KXP-PPN1793894132 |e 407318038X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Sílvia Nosàs-Garcia, Thomas Moehler, Klaus Wasser, Fabian Kiessling, Reiner Bartl, Ivan Zuna, Jens Hillengass, Hartmut Goldschmidt, Hans-Ulrich Kauczor, and Stefan Delorme"]},"id":{"eki":["1793894132"],"doi":["10.1002/jmri.20349"]},"relHost":[{"titleAlt":[{"title":"JMRI"}],"pubHistory":["1.1991 -"],"id":{"doi":["10.1002/(ISSN)1522-2586"],"zdb":["1497154-9"],"eki":["306360039"],"issn":["1522-2586"]},"part":{"extent":"7","text":"22(2005), 1 vom: Juni, Seite 154-162","issue":"1","pages":"154-162","volume":"22","year":"2005"},"origin":[{"publisherPlace":"New York, NY","dateIssuedKey":"1991","dateIssuedDisp":"1991-","publisher":"Wiley-Liss"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 28.02.08","Fortsetzung der CD-ROM-Ausgabe"],"title":[{"subtitle":"JMRI ; an official journal of the International Society for Magnetic Resonance in Medicine","title_sort":"Journal of magnetic resonance imaging","title":"Journal of magnetic resonance imaging"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"306360039","disp":"Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma a comparative study with histology and clinical markersJournal of magnetic resonance imaging"}],"person":[{"display":"Nosàs-Garcia, Sílvia","family":"Nosàs-Garcia","given":"Sílvia","role":"aut"},{"display":"Möhler, Thomas","family":"Möhler","given":"Thomas","role":"aut"},{"display":"Wasser, Klaus","family":"Wasser","given":"Klaus","role":"aut"},{"display":"Kießling, Fabian","family":"Kießling","given":"Fabian","role":"aut"},{"display":"Bartl, Reiner","family":"Bartl","role":"aut","given":"Reiner"},{"family":"Zuna","given":"Ivan","role":"aut","display":"Zuna, Ivan"},{"display":"Hillengaß, Jens","role":"aut","given":"Jens","family":"Hillengaß"},{"display":"Goldschmidt, Hartmut","given":"Hartmut","role":"aut","family":"Goldschmidt"},{"role":"aut","given":"Hans-Ulrich","family":"Kauczor","display":"Kauczor, Hans-Ulrich"},{"display":"Delorme, Stefan","given":"Stefan","role":"aut","family":"Delorme"}],"origin":[{"dateIssuedDisp":"21 June 2005","dateIssuedKey":"2005"}],"title":[{"subtitle":"a comparative study with histology and clinical markers","title_sort":"Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma","title":"Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma"}],"note":["Gesehen am 25.02.2022"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1793894132","physDesc":[{"noteIll":"Illustrationen","extent":"7 S."}]} | ||
| SRT | |a NOSASGARCIDYNAMICCON2120 | ||