Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
Bortezomib, an inhibitor of proteasomes (sites of protein degradation in cells), has activity against advanced multiple myeloma. This study compared bortezomib with high-dose dexamethasone relatively soon after a relapse of multiple myeloma had occurred with other treatments. Bortezomib was superior...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 16, 2005
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| In: |
The New England journal of medicine
Year: 2005, Jahrgang: 352, Heft: 24, Pages: 2487-2498 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa043445 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa043445
|
| Verfasserangaben: | Paul G. Richardson, Pieter Sonneveld, Michael W. Schuster, David Irwin, Edward A. Stadtmauer, Thierry Facon, Jean-Luc Harousseau, Dina Ben-Yehuda, Sagar Lonial, Hartmut Goldschmidt, Donna Reece, Jesus F. San-Miguel, Joan Bladé, Mario Boccadoro, Jamie Cavenagh, William S. Dalton, Anthony L. Boral, Dixie L. Esseltine, Jane B. Porter, David Schenkein, and Kenneth C. Anderson for the Assessment of Proteasome Inhibition for Extending Remissions (APEX) Investigator |
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| 520 | |a Bortezomib, an inhibitor of proteasomes (sites of protein degradation in cells), has activity against advanced multiple myeloma. This study compared bortezomib with high-dose dexamethasone relatively soon after a relapse of multiple myeloma had occurred with other treatments. Bortezomib was superior to dexamethasone in all end points and prolonged overall survival. | ||
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